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Gene: KIAA1328 |
Gene summary for KIAA1328 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KIAA1328 | Gene ID | 57536 |
| Gene name | KIAA1328 | |
| Gene Alias | KIAA1328 | |
| Cytomap | 18q12.2 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q86T90 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57536 | KIAA1328 | RNA-P17T-P17T-2 | Human | Lung | IAC | 2.13e-03 | 4.18e-01 | 0.3371 |
| 57536 | KIAA1328 | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.71e-02 | 3.87e-01 | 0.343 |
| 57536 | KIAA1328 | RNA-P17T-P17T-6 | Human | Lung | IAC | 4.71e-02 | 3.86e-01 | 0.3385 |
| 57536 | KIAA1328 | RNA-P23T2-P23T2-1 | Human | Lung | MIAC | 2.13e-03 | 7.54e-01 | -0.037 |
| 57536 | KIAA1328 | RNA-P23T2-P23T2-4 | Human | Lung | MIAC | 9.90e-04 | 9.22e-01 | -0.0272 |
| 57536 | KIAA1328 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.49e-13 | 6.24e-01 | -0.2116 |
| 57536 | KIAA1328 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 9.39e-09 | 7.88e-01 | -0.1941 |
| 57536 | KIAA1328 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 4.20e-06 | 5.48e-01 | -0.2107 |
| 57536 | KIAA1328 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.01e-09 | 5.81e-01 | -0.2119 |
| 57536 | KIAA1328 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.10e-09 | 3.71e-01 | -0.0166 |
| 57536 | KIAA1328 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 6.53e-06 | 2.56e-01 | -0.0132 |
| 57536 | KIAA1328 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 3.91e-04 | 2.09e-01 | -0.013 |
| 57536 | KIAA1328 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 5.70e-05 | 2.46e-01 | -0.0121 |
| 57536 | KIAA1328 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.01e-04 | 5.59e-01 | -0.0822 |
| 57536 | KIAA1328 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 2.35e-06 | 5.45e-01 | -0.0809 |
| 57536 | KIAA1328 | HTA12-15-2 | Human | Pancreas | PDAC | 4.92e-06 | 4.69e-01 | 0.2315 |
| 57536 | KIAA1328 | HTA12-23-1 | Human | Pancreas | PDAC | 1.89e-07 | 7.57e-01 | 0.3405 |
| 57536 | KIAA1328 | HTA12-25-1 | Human | Pancreas | PDAC | 2.44e-10 | 9.01e-01 | 0.313 |
| 57536 | KIAA1328 | HTA12-26-1 | Human | Pancreas | PDAC | 3.84e-16 | 8.50e-01 | 0.3728 |
| 57536 | KIAA1328 | HTA12-29-1 | Human | Pancreas | PDAC | 2.70e-40 | 9.00e-01 | 0.3722 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KIAA1328 | SNV | Missense_Mutation | c.1016G>C | p.Arg339Pro | p.R339P | Q86T90 | protein_coding | tolerated(0.23) | benign(0.284) | TCGA-DD-A114-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| KIAA1328 | SNV | Missense_Mutation | c.987N>C | p.Lys329Asn | p.K329N | Q86T90 | protein_coding | tolerated(0.25) | benign(0.007) | TCGA-DD-A4NO-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| KIAA1328 | SNV | Missense_Mutation | rs751677814 | c.1514N>A | p.Thr505Asn | p.T505N | Q86T90 | protein_coding | tolerated(0.39) | benign(0) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| KIAA1328 | SNV | Missense_Mutation | c.550G>A | p.Gly184Ser | p.G184S | Q86T90 | protein_coding | tolerated(0.75) | benign(0.116) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| KIAA1328 | SNV | Missense_Mutation | c.1440N>G | p.Asp480Glu | p.D480E | Q86T90 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-62-8398-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | CR | |
| KIAA1328 | SNV | Missense_Mutation | novel | c.390N>A | p.Phe130Leu | p.F130L | Q86T90 | protein_coding | deleterious(0) | benign(0.09) | TCGA-62-A470-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| KIAA1328 | SNV | Missense_Mutation | c.1048N>A | p.Gly350Arg | p.G350R | Q86T90 | protein_coding | tolerated(0.55) | benign(0.003) | TCGA-18-5592-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| KIAA1328 | SNV | Missense_Mutation | novel | c.251G>T | p.Gly84Val | p.G84V | Q86T90 | protein_coding | deleterious(0.02) | possibly_damaging(0.79) | TCGA-85-8666-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| KIAA1328 | SNV | Missense_Mutation | novel | c.227N>C | p.Val76Ala | p.V76A | Q86T90 | protein_coding | tolerated(0.23) | benign(0.007) | TCGA-CV-5432-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| KIAA1328 | SNV | Missense_Mutation | novel | c.958N>T | p.Pro320Ser | p.P320S | Q86T90 | protein_coding | tolerated(0.44) | benign(0.007) | TCGA-CV-5432-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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