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Gene: KIAA0930 |
Gene summary for KIAA0930 |
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Gene information | Species | Human | Gene symbol | KIAA0930 | Gene ID | 23313 |
Gene name | KIAA0930 | |
Gene Alias | C22orf9 | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q6ICG6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23313 | KIAA0930 | LZE4T | Human | Esophagus | ESCC | 2.52e-06 | 7.87e-02 | 0.0811 |
23313 | KIAA0930 | LZE5T | Human | Esophagus | ESCC | 1.62e-03 | 4.96e-02 | 0.0514 |
23313 | KIAA0930 | LZE7T | Human | Esophagus | ESCC | 5.65e-06 | 3.91e-01 | 0.0667 |
23313 | KIAA0930 | LZE20T | Human | Esophagus | ESCC | 1.74e-03 | 2.45e-02 | 0.0662 |
23313 | KIAA0930 | LZE22T | Human | Esophagus | ESCC | 1.12e-04 | 7.87e-02 | 0.068 |
23313 | KIAA0930 | LZE24T | Human | Esophagus | ESCC | 8.02e-11 | 3.26e-02 | 0.0596 |
23313 | KIAA0930 | LZE6T | Human | Esophagus | ESCC | 4.47e-03 | -5.03e-02 | 0.0845 |
23313 | KIAA0930 | P1T-E | Human | Esophagus | ESCC | 6.15e-04 | 3.22e-01 | 0.0875 |
23313 | KIAA0930 | P2T-E | Human | Esophagus | ESCC | 1.21e-09 | -2.74e-02 | 0.1177 |
23313 | KIAA0930 | P4T-E | Human | Esophagus | ESCC | 3.95e-10 | 2.59e-01 | 0.1323 |
23313 | KIAA0930 | P5T-E | Human | Esophagus | ESCC | 2.29e-16 | 8.61e-03 | 0.1327 |
23313 | KIAA0930 | P8T-E | Human | Esophagus | ESCC | 6.10e-15 | 1.04e-01 | 0.0889 |
23313 | KIAA0930 | P9T-E | Human | Esophagus | ESCC | 5.88e-15 | 2.06e-01 | 0.1131 |
23313 | KIAA0930 | P10T-E | Human | Esophagus | ESCC | 1.44e-14 | 1.63e-01 | 0.116 |
23313 | KIAA0930 | P11T-E | Human | Esophagus | ESCC | 1.01e-06 | 3.18e-01 | 0.1426 |
23313 | KIAA0930 | P12T-E | Human | Esophagus | ESCC | 1.71e-22 | 2.22e-01 | 0.1122 |
23313 | KIAA0930 | P15T-E | Human | Esophagus | ESCC | 8.67e-16 | 2.94e-01 | 0.1149 |
23313 | KIAA0930 | P16T-E | Human | Esophagus | ESCC | 1.42e-07 | -5.34e-02 | 0.1153 |
23313 | KIAA0930 | P17T-E | Human | Esophagus | ESCC | 1.65e-10 | 2.28e-01 | 0.1278 |
23313 | KIAA0930 | P19T-E | Human | Esophagus | ESCC | 4.84e-03 | 2.03e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0930 | SNV | Missense_Mutation | novel | c.1017N>T | p.Glu339Asp | p.E339D | Q6ICG6 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-95-A4VN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0930 | SNV | Missense_Mutation | novel | c.475N>A | p.Glu159Lys | p.E159K | Q6ICG6 | protein_coding | deleterious(0.01) | benign(0.436) | TCGA-21-1077-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
KIAA0930 | SNV | Missense_Mutation | novel | c.244N>C | p.Glu82Gln | p.E82Q | Q6ICG6 | protein_coding | tolerated(0.51) | benign(0) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KIAA0930 | SNV | Missense_Mutation | novel | c.768N>T | p.Lys256Asn | p.K256N | Q6ICG6 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-NC-A5HJ-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
KIAA0930 | SNV | Missense_Mutation | novel | c.224G>A | p.Gly75Glu | p.G75E | Q6ICG6 | protein_coding | tolerated(0.11) | probably_damaging(0.967) | TCGA-CQ-5324-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
KIAA0930 | SNV | Missense_Mutation | novel | c.265N>T | p.Arg89Trp | p.R89W | Q6ICG6 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-CR-6488-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA0930 | SNV | Missense_Mutation | novel | c.436N>C | p.Phe146Leu | p.F146L | Q6ICG6 | protein_coding | deleterious(0.01) | possibly_damaging(0.523) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA0930 | SNV | Missense_Mutation | c.986N>T | p.Ser329Leu | p.S329L | Q6ICG6 | protein_coding | deleterious(0) | possibly_damaging(0.766) | TCGA-IQ-A61I-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIAA0930 | SNV | Missense_Mutation | rs146302383 | c.325N>A | p.Val109Ile | p.V109I | Q6ICG6 | protein_coding | deleterious(0) | benign(0.369) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
KIAA0930 | SNV | Missense_Mutation | rs773175119 | c.745C>T | p.Arg249Cys | p.R249C | Q6ICG6 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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