![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KHDRBS3 |
Gene summary for KHDRBS3 |
![]() |
Gene information | Species | Human | Gene symbol | KHDRBS3 | Gene ID | 10656 |
Gene name | KH RNA binding domain containing, signal transduction associated 3 | |
Gene Alias | Etle | |
Cytomap | 8q24.23 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | O75525 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10656 | KHDRBS3 | P2T-E | Human | Esophagus | ESCC | 3.26e-13 | 2.16e-01 | 0.1177 |
10656 | KHDRBS3 | P5T-E | Human | Esophagus | ESCC | 5.45e-13 | 3.49e-01 | 0.1327 |
10656 | KHDRBS3 | P10T-E | Human | Esophagus | ESCC | 1.17e-10 | 6.36e-02 | 0.116 |
10656 | KHDRBS3 | P11T-E | Human | Esophagus | ESCC | 2.74e-03 | 1.68e-01 | 0.1426 |
10656 | KHDRBS3 | P12T-E | Human | Esophagus | ESCC | 1.29e-07 | 1.56e-01 | 0.1122 |
10656 | KHDRBS3 | P16T-E | Human | Esophagus | ESCC | 1.24e-16 | 4.59e-01 | 0.1153 |
10656 | KHDRBS3 | P22T-E | Human | Esophagus | ESCC | 1.38e-04 | 5.91e-04 | 0.1236 |
10656 | KHDRBS3 | P24T-E | Human | Esophagus | ESCC | 1.58e-02 | 6.84e-02 | 0.1287 |
10656 | KHDRBS3 | P26T-E | Human | Esophagus | ESCC | 1.37e-08 | 2.07e-01 | 0.1276 |
10656 | KHDRBS3 | P28T-E | Human | Esophagus | ESCC | 4.00e-09 | 1.34e-01 | 0.1149 |
10656 | KHDRBS3 | P30T-E | Human | Esophagus | ESCC | 6.75e-05 | 1.71e-01 | 0.137 |
10656 | KHDRBS3 | P32T-E | Human | Esophagus | ESCC | 1.27e-03 | 8.34e-02 | 0.1666 |
10656 | KHDRBS3 | P37T-E | Human | Esophagus | ESCC | 3.89e-02 | -6.41e-02 | 0.1371 |
10656 | KHDRBS3 | P42T-E | Human | Esophagus | ESCC | 3.59e-03 | 3.75e-02 | 0.1175 |
10656 | KHDRBS3 | P47T-E | Human | Esophagus | ESCC | 4.34e-02 | -1.63e-02 | 0.1067 |
10656 | KHDRBS3 | P52T-E | Human | Esophagus | ESCC | 9.16e-06 | 3.25e-02 | 0.1555 |
10656 | KHDRBS3 | P54T-E | Human | Esophagus | ESCC | 7.24e-16 | 2.50e-01 | 0.0975 |
10656 | KHDRBS3 | P56T-E | Human | Esophagus | ESCC | 8.34e-06 | 6.71e-01 | 0.1613 |
10656 | KHDRBS3 | P61T-E | Human | Esophagus | ESCC | 1.01e-03 | -4.16e-02 | 0.099 |
10656 | KHDRBS3 | P74T-E | Human | Esophagus | ESCC | 8.85e-04 | 3.19e-02 | 0.1479 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:0043484111 | Esophagus | ESCC | regulation of RNA splicing | 116/8552 | 148/18723 | 3.18e-16 | 2.38e-14 | 116 |
GO:0050684110 | Esophagus | ESCC | regulation of mRNA processing | 109/8552 | 137/18723 | 3.51e-16 | 2.59e-14 | 109 |
GO:0048024111 | Esophagus | ESCC | regulation of mRNA splicing, via spliceosome | 78/8552 | 101/18723 | 8.72e-11 | 2.66e-09 | 78 |
GO:000038019 | Esophagus | ESCC | alternative mRNA splicing, via spliceosome | 55/8552 | 77/18723 | 4.07e-06 | 4.38e-05 | 55 |
GO:000038119 | Esophagus | ESCC | regulation of alternative mRNA splicing, via spliceosome | 40/8552 | 60/18723 | 8.30e-04 | 4.28e-03 | 40 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:190331121 | Liver | HCC | regulation of mRNA metabolic process | 205/7958 | 288/18723 | 3.38e-23 | 6.90e-21 | 205 |
GO:004348422 | Liver | HCC | regulation of RNA splicing | 113/7958 | 148/18723 | 4.32e-17 | 4.15e-15 | 113 |
GO:005068421 | Liver | HCC | regulation of mRNA processing | 106/7958 | 137/18723 | 7.64e-17 | 7.12e-15 | 106 |
GO:004802422 | Liver | HCC | regulation of mRNA splicing, via spliceosome | 74/7958 | 101/18723 | 3.29e-10 | 1.10e-08 | 74 |
GO:000038021 | Liver | HCC | alternative mRNA splicing, via spliceosome | 52/7958 | 77/18723 | 7.87e-06 | 9.27e-05 | 52 |
GO:000038121 | Liver | HCC | regulation of alternative mRNA splicing, via spliceosome | 37/7958 | 60/18723 | 2.13e-03 | 1.07e-02 | 37 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KHDRBS3 | SNV | Missense_Mutation | rs771409135 | c.382N>T | p.His128Tyr | p.H128Y | O75525 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KHDRBS3 | SNV | Missense_Mutation | novel | c.432N>T | p.Met144Ile | p.M144I | O75525 | protein_coding | tolerated(0.11) | benign(0.078) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
KHDRBS3 | SNV | Missense_Mutation | c.202C>A | p.Pro68Thr | p.P68T | O75525 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-60-2714-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD | |
KHDRBS3 | SNV | Missense_Mutation | c.629N>A | p.Thr210Lys | p.T210K | O75525 | protein_coding | tolerated(0.25) | benign(0.066) | TCGA-66-2744-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KHDRBS3 | SNV | Missense_Mutation | novel | c.550C>T | p.Pro184Ser | p.P184S | O75525 | protein_coding | tolerated(0.17) | benign(0.037) | TCGA-77-8154-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KHDRBS3 | SNV | Missense_Mutation | novel | c.761N>T | p.Tyr254Phe | p.Y254F | O75525 | protein_coding | tolerated(0.15) | probably_damaging(0.958) | TCGA-CR-7399-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KHDRBS3 | SNV | Missense_Mutation | rs749093786 | c.620N>A | p.Gly207Glu | p.G207E | O75525 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-CV-7101-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KHDRBS3 | SNV | Missense_Mutation | novel | c.269N>T | p.Glu90Val | p.E90V | O75525 | protein_coding | deleterious(0) | benign(0.287) | TCGA-CV-7177-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KHDRBS3 | SNV | Missense_Mutation | c.255N>T | p.Lys85Asn | p.K85N | O75525 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EJ-5525-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
KHDRBS3 | SNV | Missense_Mutation | c.256N>T | p.Arg86Cys | p.R86C | O75525 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EJ-5525-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |