![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KCMF1 |
Gene summary for KCMF1 |
![]() |
Gene information | Species | Human | Gene symbol | KCMF1 | Gene ID | 56888 |
Gene name | potassium channel modulatory factor 1 | |
Gene Alias | DEBT91 | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9P0J7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56888 | KCMF1 | CA_HPV_1 | Human | Cervix | CC | 2.37e-03 | -7.24e-02 | 0.0264 |
56888 | KCMF1 | CCI_2 | Human | Cervix | CC | 3.05e-07 | 8.22e-01 | 0.5249 |
56888 | KCMF1 | CCI_3 | Human | Cervix | CC | 3.06e-03 | 5.33e-01 | 0.516 |
56888 | KCMF1 | sample3 | Human | Cervix | CC | 7.01e-05 | 2.97e-01 | 0.1387 |
56888 | KCMF1 | T3 | Human | Cervix | CC | 7.89e-04 | 2.84e-01 | 0.1389 |
56888 | KCMF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.92e-07 | -2.41e-01 | 0.0155 |
56888 | KCMF1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.26e-02 | 3.65e-01 | -0.1954 |
56888 | KCMF1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.40e-03 | -3.03e-01 | 0.096 |
56888 | KCMF1 | A001-C-207 | Human | Colorectum | FAP | 1.36e-03 | -2.84e-01 | 0.1278 |
56888 | KCMF1 | A015-C-203 | Human | Colorectum | FAP | 1.23e-26 | -4.14e-01 | -0.1294 |
56888 | KCMF1 | A015-C-204 | Human | Colorectum | FAP | 1.19e-04 | -2.41e-01 | -0.0228 |
56888 | KCMF1 | A014-C-040 | Human | Colorectum | FAP | 2.37e-06 | -5.68e-01 | -0.1184 |
56888 | KCMF1 | A002-C-201 | Human | Colorectum | FAP | 1.93e-09 | -1.93e-01 | 0.0324 |
56888 | KCMF1 | A001-C-119 | Human | Colorectum | FAP | 7.82e-05 | -2.61e-01 | -0.1557 |
56888 | KCMF1 | A001-C-108 | Human | Colorectum | FAP | 3.01e-13 | -2.50e-01 | -0.0272 |
56888 | KCMF1 | A002-C-205 | Human | Colorectum | FAP | 1.72e-21 | -4.76e-01 | -0.1236 |
56888 | KCMF1 | A001-C-104 | Human | Colorectum | FAP | 5.24e-05 | -2.89e-01 | 0.0184 |
56888 | KCMF1 | A015-C-005 | Human | Colorectum | FAP | 2.40e-05 | -3.10e-01 | -0.0336 |
56888 | KCMF1 | A015-C-006 | Human | Colorectum | FAP | 4.99e-14 | -4.53e-01 | -0.0994 |
56888 | KCMF1 | A015-C-106 | Human | Colorectum | FAP | 1.06e-12 | -3.75e-01 | -0.0511 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCMF1 | SNV | Missense_Mutation | c.767G>T | p.Arg256Leu | p.R256L | Q9P0J7 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-39-5027-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KCMF1 | SNV | Missense_Mutation | novel | c.476N>T | p.Arg159Leu | p.R159L | Q9P0J7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-66-2734-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCMF1 | SNV | Missense_Mutation | novel | c.442N>A | p.Val148Ile | p.V148I | Q9P0J7 | protein_coding | tolerated(0.54) | benign(0.02) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
KCMF1 | SNV | Missense_Mutation | novel | c.887N>C | p.Leu296Ser | p.L296S | Q9P0J7 | protein_coding | tolerated(0.08) | benign(0.235) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |