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Gene: ITGBL1 |
Gene summary for ITGBL1 |
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Gene information | Species | Human | Gene symbol | ITGBL1 | Gene ID | 9358 |
Gene name | integrin subunit beta like 1 | |
Gene Alias | OSCP | |
Cytomap | 13q33.1 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | B4DN32 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9358 | ITGBL1 | ATC11 | Human | Thyroid | ATC | 8.25e-07 | 6.50e-01 | 0.3386 |
9358 | ITGBL1 | ATC12 | Human | Thyroid | ATC | 4.18e-08 | 2.93e-01 | 0.34 |
9358 | ITGBL1 | ATC2 | Human | Thyroid | ATC | 1.02e-12 | 1.01e+00 | 0.34 |
9358 | ITGBL1 | ATC3 | Human | Thyroid | ATC | 4.28e-09 | 5.96e-01 | 0.338 |
9358 | ITGBL1 | ATC4 | Human | Thyroid | ATC | 4.08e-11 | 2.97e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158928 | Thyroid | ATC | cell-substrate adhesion | 195/6293 | 363/18723 | 1.58e-15 | 1.17e-13 | 195 |
GO:0007160111 | Thyroid | ATC | cell-matrix adhesion | 128/6293 | 233/18723 | 1.49e-11 | 5.41e-10 | 128 |
GO:000722919 | Thyroid | ATC | integrin-mediated signaling pathway | 63/6293 | 107/18723 | 7.09e-08 | 1.24e-06 | 63 |
GO:00336277 | Thyroid | ATC | cell adhesion mediated by integrin | 39/6293 | 72/18723 | 2.59e-04 | 1.66e-03 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITGBL1 | SNV | Missense_Mutation | c.706N>T | p.Gly236Cys | p.G236C | O95965 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
ITGBL1 | SNV | Missense_Mutation | c.1432N>T | p.Asp478Tyr | p.D478Y | O95965 | protein_coding | deleterious(0.02) | probably_damaging(0.935) | TCGA-33-4586-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
ITGBL1 | SNV | Missense_Mutation | c.1351N>A | p.Asp451Asn | p.D451N | O95965 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ITGBL1 | SNV | Missense_Mutation | novel | c.1000N>A | p.Pro334Thr | p.P334T | O95965 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ITGBL1 | SNV | Missense_Mutation | novel | c.571G>A | p.Glu191Lys | p.E191K | O95965 | protein_coding | tolerated(0.13) | benign(0.411) | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ITGBL1 | SNV | Missense_Mutation | novel | c.944N>A | p.Ser315Tyr | p.S315Y | O95965 | protein_coding | deleterious(0) | possibly_damaging(0.698) | TCGA-56-8626-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ITGBL1 | SNV | Missense_Mutation | novel | c.548N>C | p.Arg183Thr | p.R183T | O95965 | protein_coding | tolerated(0.31) | benign(0.009) | TCGA-58-A46M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ITGBL1 | SNV | Missense_Mutation | novel | c.1379G>A | p.Gly460Asp | p.G460D | O95965 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-77-8133-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ITGBL1 | SNV | Missense_Mutation | rs763196114 | c.919N>T | p.Gly307Trp | p.G307W | O95965 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-85-6560-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ITGBL1 | SNV | Missense_Mutation | novel | c.98N>C | p.Arg33Thr | p.R33T | O95965 | protein_coding | deleterious_low_confidence(0.01) | benign(0.038) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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