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Gene: ITFG1 |
Gene summary for ITFG1 |
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Gene information | Species | Human | Gene symbol | ITFG1 | Gene ID | 81533 |
Gene name | integrin alpha FG-GAP repeat containing 1 | |
Gene Alias | 2310047C21Rik | |
Cytomap | 16q12.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B4DXC2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81533 | ITFG1 | CCI_1 | Human | Cervix | CC | 2.44e-08 | 1.10e+00 | 0.528 |
81533 | ITFG1 | CCI_2 | Human | Cervix | CC | 8.26e-05 | 8.57e-01 | 0.5249 |
81533 | ITFG1 | CCI_3 | Human | Cervix | CC | 1.28e-07 | 1.03e+00 | 0.516 |
81533 | ITFG1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.66e-26 | -7.28e-01 | 0.0155 |
81533 | ITFG1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.45e-04 | -4.29e-01 | -0.1808 |
81533 | ITFG1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.94e-02 | -6.25e-01 | 0.0216 |
81533 | ITFG1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.28e-13 | -6.11e-01 | -0.1207 |
81533 | ITFG1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.80e-07 | -2.83e-01 | -0.1464 |
81533 | ITFG1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.20e-02 | -4.71e-01 | -0.2061 |
81533 | ITFG1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.06e-04 | -8.08e-01 | -0.00410000000000005 |
81533 | ITFG1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.30e-05 | -4.19e-01 | -0.0179 |
81533 | ITFG1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.11e-21 | -6.12e-01 | 0.096 |
81533 | ITFG1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.57e-05 | -7.74e-01 | 0.0528 |
81533 | ITFG1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.07e-07 | -5.44e-01 | 0.0338 |
81533 | ITFG1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.13e-08 | -4.67e-01 | 0.0674 |
81533 | ITFG1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.33e-02 | -4.24e-01 | 0.0112 |
81533 | ITFG1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.18e-04 | -5.09e-01 | 0.0588 |
81533 | ITFG1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.62e-16 | -5.06e-01 | 0.294 |
81533 | ITFG1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.20e-03 | -3.39e-01 | 0.3859 |
81533 | ITFG1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.29e-06 | -5.33e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITFG1 | SNV | Missense_Mutation | novel | c.421N>G | p.Thr141Ala | p.T141A | Q8TB96 | protein_coding | tolerated(0.11) | benign(0.09) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR |
ITFG1 | SNV | Missense_Mutation | rs763581458 | c.1081N>T | p.Ala361Ser | p.A361S | Q8TB96 | protein_coding | tolerated(0.14) | possibly_damaging(0.829) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
ITFG1 | SNV | Missense_Mutation | c.430C>T | p.Pro144Ser | p.P144S | Q8TB96 | protein_coding | tolerated(0.49) | benign(0.001) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ITFG1 | SNV | Missense_Mutation | novel | c.1466G>A | p.Ser489Asn | p.S489N | Q8TB96 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-60-2696-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITFG1 | SNV | Missense_Mutation | c.241N>G | p.Asn81Asp | p.N81D | Q8TB96 | protein_coding | tolerated(0.39) | benign(0.023) | TCGA-63-5131-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD | |
ITFG1 | SNV | Missense_Mutation | rs761660313 | c.908N>C | p.Val303Ala | p.V303A | Q8TB96 | protein_coding | deleterious(0.01) | benign(0.107) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
ITFG1 | SNV | Missense_Mutation | c.1453N>T | p.Ala485Ser | p.A485S | Q8TB96 | protein_coding | tolerated(0.15) | probably_damaging(0.942) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ITFG1 | SNV | Missense_Mutation | c.1061C>T | p.Thr354Ile | p.T354I | Q8TB96 | protein_coding | tolerated(0.05) | benign(0.232) | TCGA-BA-6869-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ITFG1 | SNV | Missense_Mutation | rs771169968 | c.1126N>C | p.Glu376Gln | p.E376Q | Q8TB96 | protein_coding | tolerated(0.51) | benign(0.014) | TCGA-CR-6477-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ITFG1 | SNV | Missense_Mutation | novel | c.953N>T | p.Pro318Leu | p.P318L | Q8TB96 | protein_coding | deleterious(0.01) | possibly_damaging(0.868) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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