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Gene: IRF2BPL |
Gene summary for IRF2BPL |
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Gene information | Species | Human | Gene symbol | IRF2BPL | Gene ID | 64207 |
Gene name | interferon regulatory factor 2 binding protein like | |
Gene Alias | C14orf4 | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9H1B7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64207 | IRF2BPL | LZE4T | Human | Esophagus | ESCC | 1.21e-10 | -1.59e-01 | 0.0811 |
64207 | IRF2BPL | LZE7T | Human | Esophagus | ESCC | 4.94e-05 | -2.11e-01 | 0.0667 |
64207 | IRF2BPL | LZE8T | Human | Esophagus | ESCC | 2.15e-07 | -1.87e-01 | 0.067 |
64207 | IRF2BPL | LZE20T | Human | Esophagus | ESCC | 2.29e-12 | -5.98e-02 | 0.0662 |
64207 | IRF2BPL | LZE22D1 | Human | Esophagus | HGIN | 3.62e-08 | -7.52e-02 | 0.0595 |
64207 | IRF2BPL | LZE24T | Human | Esophagus | ESCC | 2.51e-04 | -7.86e-02 | 0.0596 |
64207 | IRF2BPL | LZE22D3 | Human | Esophagus | HGIN | 3.43e-03 | 1.84e-01 | 0.0653 |
64207 | IRF2BPL | LZE21T | Human | Esophagus | ESCC | 2.86e-04 | 1.18e-01 | 0.0655 |
64207 | IRF2BPL | LZE6T | Human | Esophagus | ESCC | 5.65e-05 | -2.25e-01 | 0.0845 |
64207 | IRF2BPL | P1T-E | Human | Esophagus | ESCC | 2.34e-04 | 3.93e-01 | 0.0875 |
64207 | IRF2BPL | P2T-E | Human | Esophagus | ESCC | 8.59e-33 | 7.06e-01 | 0.1177 |
64207 | IRF2BPL | P4T-E | Human | Esophagus | ESCC | 6.47e-11 | 1.01e-01 | 0.1323 |
64207 | IRF2BPL | P5T-E | Human | Esophagus | ESCC | 1.67e-09 | -1.88e-01 | 0.1327 |
64207 | IRF2BPL | P8T-E | Human | Esophagus | ESCC | 3.10e-19 | 1.05e-01 | 0.0889 |
64207 | IRF2BPL | P9T-E | Human | Esophagus | ESCC | 2.32e-17 | -4.65e-03 | 0.1131 |
64207 | IRF2BPL | P10T-E | Human | Esophagus | ESCC | 3.13e-16 | 1.64e-01 | 0.116 |
64207 | IRF2BPL | P11T-E | Human | Esophagus | ESCC | 4.86e-07 | 2.19e-01 | 0.1426 |
64207 | IRF2BPL | P12T-E | Human | Esophagus | ESCC | 1.94e-18 | 4.09e-01 | 0.1122 |
64207 | IRF2BPL | P15T-E | Human | Esophagus | ESCC | 6.66e-28 | 8.78e-01 | 0.1149 |
64207 | IRF2BPL | P16T-E | Human | Esophagus | ESCC | 1.74e-35 | 6.99e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IRF2BPL | SNV | Missense_Mutation | novel | c.1288G>A | p.Val430Met | p.V430M | Q9H1B7 | protein_coding | deleterious(0.03) | probably_damaging(0.94) | TCGA-HU-A4GD-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
IRF2BPL | SNV | Missense_Mutation | c.2119N>G | p.Met707Val | p.M707V | Q9H1B7 | protein_coding | tolerated(0.82) | benign(0.014) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
IRF2BPL | SNV | Missense_Mutation | novel | c.1222G>A | p.Val408Ile | p.V408I | Q9H1B7 | protein_coding | tolerated(0.11) | benign(0.211) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
IRF2BPL | insertion | Frame_Shift_Ins | novel | c.762_763insC | p.Asn255GlnfsTer9 | p.N255Qfs*9 | Q9H1B7 | protein_coding | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
IRF2BPL | SNV | Missense_Mutation | novel | c.2311G>A | p.Val771Ile | p.V771I | Q9H1B7 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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