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Gene: IQCE |
Gene summary for IQCE |
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Gene information | Species | Human | Gene symbol | IQCE | Gene ID | 23288 |
Gene name | IQ motif containing E | |
Gene Alias | 1700028P05Rik | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | A0A087WX45 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23288 | IQCE | LZE22T | Human | Esophagus | ESCC | 4.30e-02 | 2.30e-01 | 0.068 |
23288 | IQCE | LZE24T | Human | Esophagus | ESCC | 4.01e-02 | 1.13e-01 | 0.0596 |
23288 | IQCE | P1T-E | Human | Esophagus | ESCC | 3.67e-04 | 2.37e-01 | 0.0875 |
23288 | IQCE | P2T-E | Human | Esophagus | ESCC | 1.57e-17 | 3.72e-01 | 0.1177 |
23288 | IQCE | P4T-E | Human | Esophagus | ESCC | 2.27e-06 | 1.00e-01 | 0.1323 |
23288 | IQCE | P8T-E | Human | Esophagus | ESCC | 5.85e-07 | 1.27e-01 | 0.0889 |
23288 | IQCE | P10T-E | Human | Esophagus | ESCC | 6.41e-04 | 1.20e-01 | 0.116 |
23288 | IQCE | P11T-E | Human | Esophagus | ESCC | 2.20e-04 | 2.72e-01 | 0.1426 |
23288 | IQCE | P12T-E | Human | Esophagus | ESCC | 1.46e-09 | 9.28e-02 | 0.1122 |
23288 | IQCE | P15T-E | Human | Esophagus | ESCC | 1.83e-10 | 1.64e-01 | 0.1149 |
23288 | IQCE | P16T-E | Human | Esophagus | ESCC | 4.60e-11 | 2.15e-01 | 0.1153 |
23288 | IQCE | P19T-E | Human | Esophagus | ESCC | 1.10e-03 | 2.92e-01 | 0.1662 |
23288 | IQCE | P20T-E | Human | Esophagus | ESCC | 1.28e-08 | 1.18e-01 | 0.1124 |
23288 | IQCE | P21T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.46e-01 | 0.1617 |
23288 | IQCE | P22T-E | Human | Esophagus | ESCC | 1.22e-09 | 1.84e-01 | 0.1236 |
23288 | IQCE | P23T-E | Human | Esophagus | ESCC | 5.87e-06 | 1.42e-01 | 0.108 |
23288 | IQCE | P26T-E | Human | Esophagus | ESCC | 7.58e-07 | 1.48e-01 | 0.1276 |
23288 | IQCE | P27T-E | Human | Esophagus | ESCC | 5.14e-09 | 2.27e-01 | 0.1055 |
23288 | IQCE | P28T-E | Human | Esophagus | ESCC | 7.28e-09 | 1.49e-01 | 0.1149 |
23288 | IQCE | P30T-E | Human | Esophagus | ESCC | 1.37e-04 | 1.94e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487367 | Esophagus | ESCC | appendage development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
GO:00601737 | Esophagus | ESCC | limb development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IQCE | SNV | Missense_Mutation | novel | c.814N>G | p.Thr272Ala | p.T272A | protein_coding | tolerated(0.26) | benign(0.06) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IQCE | SNV | Missense_Mutation | novel | c.1264N>A | p.Leu422Met | p.L422M | protein_coding | deleterious(0.04) | possibly_damaging(0.843) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IQCE | SNV | Missense_Mutation | novel | c.386C>T | p.Ala129Val | p.A129V | protein_coding | deleterious(0.01) | possibly_damaging(0.864) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IQCE | SNV | Missense_Mutation | rs761213900 | c.799G>A | p.Ala267Thr | p.A267T | protein_coding | deleterious(0.03) | possibly_damaging(0.858) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IQCE | SNV | Missense_Mutation | rs779869006 | c.1315G>A | p.Glu439Lys | p.E439K | protein_coding | tolerated(0.2) | benign(0.157) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IQCE | insertion | Frame_Shift_Ins | rs776820361 | c.1609-1_1609insA | p.Ala540GlyfsTer5 | p.A540Gfs*5 | protein_coding | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
IQCE | SNV | Missense_Mutation | c.96N>T | p.Arg32Ser | p.R32S | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
IQCE | SNV | Missense_Mutation | rs199648730 | c.125C>T | p.Ser42Leu | p.S42L | protein_coding | deleterious(0.01) | benign(0.216) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD | |
IQCE | SNV | Missense_Mutation | rs776206111 | c.1759N>T | p.Arg587Cys | p.R587C | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-91-6831-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IQCE | SNV | Missense_Mutation | c.1526G>T | p.Arg509Leu | p.R509L | protein_coding | tolerated(0.39) | benign(0.007) | TCGA-95-A4VK-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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