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Gene: IFIT3 |
Gene summary for IFIT3 |
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Gene information | Species | Human | Gene symbol | IFIT3 | Gene ID | 3437 |
Gene name | interferon induced protein with tetratricopeptide repeats 3 | |
Gene Alias | CIG-49 | |
Cytomap | 10q23.31 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | O14879 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3437 | IFIT3 | GSM4909309 | Human | Breast | IDC | 1.09e-04 | 2.58e-01 | 0.0483 |
3437 | IFIT3 | NCCBC5 | Human | Breast | DCIS | 1.35e-14 | 6.14e-01 | 0.2046 |
3437 | IFIT3 | P2 | Human | Breast | IDC | 1.52e-14 | 6.13e-01 | 0.21 |
3437 | IFIT3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.19e-13 | 5.50e-01 | 0.294 |
3437 | IFIT3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.10e-03 | 6.24e-01 | 0.3487 |
3437 | IFIT3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.16e-04 | 3.00e-01 | 0.2585 |
3437 | IFIT3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.87e-03 | 1.25e-01 | 0.3005 |
3437 | IFIT3 | LZE20T | Human | Esophagus | ESCC | 3.92e-06 | 3.15e-01 | 0.0662 |
3437 | IFIT3 | LZE24T | Human | Esophagus | ESCC | 1.41e-30 | 1.80e+00 | 0.0596 |
3437 | IFIT3 | P1T-E | Human | Esophagus | ESCC | 6.74e-05 | 5.59e-01 | 0.0875 |
3437 | IFIT3 | P2T-E | Human | Esophagus | ESCC | 4.34e-39 | 1.12e+00 | 0.1177 |
3437 | IFIT3 | P5T-E | Human | Esophagus | ESCC | 1.71e-09 | 5.81e-01 | 0.1327 |
3437 | IFIT3 | P8T-E | Human | Esophagus | ESCC | 6.86e-34 | 1.03e+00 | 0.0889 |
3437 | IFIT3 | P9T-E | Human | Esophagus | ESCC | 6.85e-37 | 1.28e+00 | 0.1131 |
3437 | IFIT3 | P11T-E | Human | Esophagus | ESCC | 5.80e-42 | 1.71e+00 | 0.1426 |
3437 | IFIT3 | P15T-E | Human | Esophagus | ESCC | 2.09e-09 | 3.79e-01 | 0.1149 |
3437 | IFIT3 | P17T-E | Human | Esophagus | ESCC | 7.22e-18 | 1.27e+00 | 0.1278 |
3437 | IFIT3 | P19T-E | Human | Esophagus | ESCC | 2.29e-02 | 6.22e-01 | 0.1662 |
3437 | IFIT3 | P20T-E | Human | Esophagus | ESCC | 3.45e-09 | 1.26e+00 | 0.1124 |
3437 | IFIT3 | P21T-E | Human | Esophagus | ESCC | 3.85e-13 | 8.28e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00096157 | Breast | IDC | response to virus | 47/1434 | 367/18723 | 3.53e-04 | 5.16e-03 | 47 |
GO:00354552 | Breast | IDC | response to interferon-alpha | 7/1434 | 21/18723 | 6.80e-04 | 8.36e-03 | 7 |
GO:000961512 | Breast | DCIS | response to virus | 45/1390 | 367/18723 | 6.16e-04 | 7.82e-03 | 45 |
GO:003545511 | Breast | DCIS | response to interferon-alpha | 6/1390 | 21/18723 | 3.40e-03 | 2.85e-02 | 6 |
GO:0009615 | Colorectum | MSI-H | response to virus | 40/1319 | 367/18723 | 3.99e-03 | 4.61e-02 | 40 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:00354555 | Esophagus | ESCC | response to interferon-alpha | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:00096155 | Liver | Cirrhotic | response to virus | 126/4634 | 367/18723 | 2.10e-05 | 2.77e-04 | 126 |
GO:0035455 | Liver | Cirrhotic | response to interferon-alpha | 11/4634 | 21/18723 | 5.89e-03 | 2.95e-02 | 11 |
GO:0051607 | Liver | Cirrhotic | defense response to virus | 84/4634 | 265/18723 | 6.02e-03 | 3.00e-02 | 84 |
GO:0140546 | Liver | Cirrhotic | defense response to symbiont | 84/4634 | 265/18723 | 6.02e-03 | 3.00e-02 | 84 |
GO:000961511 | Liver | HCC | response to virus | 210/7958 | 367/18723 | 7.32e-09 | 1.86e-07 | 210 |
GO:00516071 | Liver | HCC | defense response to virus | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:01405461 | Liver | HCC | defense response to symbiont | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:000961515 | Oral cavity | OSCC | response to virus | 215/7305 | 367/18723 | 1.63e-14 | 9.41e-13 | 215 |
GO:00516074 | Oral cavity | OSCC | defense response to virus | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
GO:01405464 | Oral cavity | OSCC | defense response to symbiont | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
GO:00354554 | Oral cavity | OSCC | response to interferon-alpha | 16/7305 | 21/18723 | 5.99e-04 | 3.39e-03 | 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFIT3 | SNV | Missense_Mutation | rs151167903 | c.1006N>A | p.Ala336Thr | p.A336T | O14879 | protein_coding | tolerated(0.32) | benign(0.271) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
IFIT3 | SNV | Missense_Mutation | rs113402097 | c.1330N>T | p.Arg444Cys | p.R444C | O14879 | protein_coding | tolerated(0.28) | possibly_damaging(0.54) | TCGA-BR-4191-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | SD |
IFIT3 | SNV | Missense_Mutation | c.345N>G | p.Ile115Met | p.I115M | O14879 | protein_coding | tolerated(0.28) | benign(0.102) | TCGA-BR-6458-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
IFIT3 | SNV | Missense_Mutation | c.1248N>G | p.Asn416Lys | p.N416K | O14879 | protein_coding | tolerated(0.16) | benign(0.348) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
IFIT3 | SNV | Missense_Mutation | c.158N>C | p.Met53Thr | p.M53T | O14879 | protein_coding | tolerated(0.15) | benign(0.139) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
IFIT3 | SNV | Missense_Mutation | novel | c.693A>C | p.Glu231Asp | p.E231D | O14879 | protein_coding | deleterious(0.04) | benign(0.178) | TCGA-CG-5725-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | PD |
IFIT3 | SNV | Missense_Mutation | novel | c.59T>A | p.Phe20Tyr | p.F20Y | O14879 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
IFIT3 | insertion | Frame_Shift_Ins | novel | c.1164_1165insGC | p.Ser389AlafsTer36 | p.S389Afs*36 | O14879 | protein_coding | TCGA-EL-A3ZP-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
IFIT3 | insertion | Frame_Shift_Ins | novel | c.1165_1166insTATT | p.Ser389IlefsTer7 | p.S389Ifs*7 | O14879 | protein_coding | TCGA-EL-A3ZP-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
IFIT3 | insertion | In_Frame_Ins | novel | c.1164_1165insGCATATTGCTTT | p.Ile388_Ser389insAlaTyrCysPhe | p.I388_S389insAYCF | O14879 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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