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Gene: HOOK1 |
Gene summary for HOOK1 |
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Gene information | Species | Human | Gene symbol | HOOK1 | Gene ID | 51361 |
Gene name | hook microtubule tethering protein 1 | |
Gene Alias | HK1 | |
Cytomap | 1p32.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UJC3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51361 | HOOK1 | LZE4T | Human | Esophagus | ESCC | 3.49e-03 | -2.73e-02 | 0.0811 |
51361 | HOOK1 | LZE20T | Human | Esophagus | ESCC | 3.92e-06 | 1.23e-01 | 0.0662 |
51361 | HOOK1 | LZE24T | Human | Esophagus | ESCC | 1.91e-20 | 3.15e-01 | 0.0596 |
51361 | HOOK1 | P1T-E | Human | Esophagus | ESCC | 7.72e-07 | 2.78e-01 | 0.0875 |
51361 | HOOK1 | P2T-E | Human | Esophagus | ESCC | 4.13e-21 | 3.12e-01 | 0.1177 |
51361 | HOOK1 | P4T-E | Human | Esophagus | ESCC | 5.08e-11 | 2.18e-01 | 0.1323 |
51361 | HOOK1 | P5T-E | Human | Esophagus | ESCC | 7.93e-14 | 1.85e-01 | 0.1327 |
51361 | HOOK1 | P8T-E | Human | Esophagus | ESCC | 6.07e-15 | 1.91e-01 | 0.0889 |
51361 | HOOK1 | P9T-E | Human | Esophagus | ESCC | 4.16e-03 | -7.50e-02 | 0.1131 |
51361 | HOOK1 | P10T-E | Human | Esophagus | ESCC | 2.56e-02 | -4.17e-02 | 0.116 |
51361 | HOOK1 | P12T-E | Human | Esophagus | ESCC | 4.50e-15 | 4.16e-01 | 0.1122 |
51361 | HOOK1 | P15T-E | Human | Esophagus | ESCC | 6.93e-05 | 6.71e-02 | 0.1149 |
51361 | HOOK1 | P16T-E | Human | Esophagus | ESCC | 9.20e-10 | 3.81e-02 | 0.1153 |
51361 | HOOK1 | P20T-E | Human | Esophagus | ESCC | 4.30e-19 | 5.37e-01 | 0.1124 |
51361 | HOOK1 | P21T-E | Human | Esophagus | ESCC | 6.60e-03 | -9.40e-02 | 0.1617 |
51361 | HOOK1 | P22T-E | Human | Esophagus | ESCC | 2.65e-08 | -7.53e-02 | 0.1236 |
51361 | HOOK1 | P23T-E | Human | Esophagus | ESCC | 7.77e-17 | 4.13e-01 | 0.108 |
51361 | HOOK1 | P24T-E | Human | Esophagus | ESCC | 3.36e-07 | 3.87e-02 | 0.1287 |
51361 | HOOK1 | P26T-E | Human | Esophagus | ESCC | 5.17e-18 | 3.69e-01 | 0.1276 |
51361 | HOOK1 | P27T-E | Human | Esophagus | ESCC | 2.24e-42 | 9.96e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:001648210 | Esophagus | ESCC | cytosolic transport | 124/8552 | 168/18723 | 9.69e-14 | 4.69e-12 | 124 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:00070419 | Esophagus | ESCC | lysosomal transport | 83/8552 | 114/18723 | 3.52e-09 | 7.41e-08 | 83 |
GO:000703214 | Esophagus | ESCC | endosome organization | 61/8552 | 82/18723 | 1.13e-07 | 1.85e-06 | 61 |
GO:00989278 | Esophagus | ESCC | vesicle-mediated transport between endosomal compartments | 36/8552 | 43/18723 | 2.90e-07 | 4.20e-06 | 36 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:00450226 | Esophagus | ESCC | early endosome to late endosome transport | 33/8552 | 40/18723 | 1.80e-06 | 2.11e-05 | 33 |
GO:00070403 | Esophagus | ESCC | lysosome organization | 53/8552 | 74/18723 | 5.34e-06 | 5.57e-05 | 53 |
GO:00801713 | Esophagus | ESCC | lytic vacuole organization | 53/8552 | 74/18723 | 5.34e-06 | 5.57e-05 | 53 |
GO:00083333 | Esophagus | ESCC | endosome to lysosome transport | 40/8552 | 55/18723 | 4.27e-05 | 3.42e-04 | 40 |
GO:00311227 | Esophagus | ESCC | cytoplasmic microtubule organization | 38/8552 | 56/18723 | 6.60e-04 | 3.50e-03 | 38 |
GO:001605011 | Liver | Cirrhotic | vesicle organization | 133/4634 | 300/18723 | 7.35e-14 | 6.41e-12 | 133 |
GO:000703411 | Liver | Cirrhotic | vacuolar transport | 75/4634 | 157/18723 | 3.13e-10 | 1.53e-08 | 75 |
GO:00070332 | Liver | Cirrhotic | vacuole organization | 80/4634 | 180/18723 | 5.73e-09 | 2.25e-07 | 80 |
GO:001648211 | Liver | Cirrhotic | cytosolic transport | 74/4634 | 168/18723 | 3.34e-08 | 1.12e-06 | 74 |
GO:00070301 | Liver | Cirrhotic | Golgi organization | 68/4634 | 157/18723 | 2.57e-07 | 6.41e-06 | 68 |
GO:00070325 | Liver | Cirrhotic | endosome organization | 41/4634 | 82/18723 | 6.91e-07 | 1.47e-05 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOOK1 | SNV | Missense_Mutation | novel | c.1922N>C | p.Lys641Thr | p.K641T | Q9UJC3 | protein_coding | deleterious(0) | possibly_damaging(0.906) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOOK1 | SNV | Missense_Mutation | novel | c.169G>A | p.Glu57Lys | p.E57K | Q9UJC3 | protein_coding | deleterious(0.03) | possibly_damaging(0.453) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
HOOK1 | SNV | Missense_Mutation | rs765680225 | c.645G>T | p.Lys215Asn | p.K215N | Q9UJC3 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
HOOK1 | SNV | Missense_Mutation | rs367708992 | c.850N>A | p.Glu284Lys | p.E284K | Q9UJC3 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOOK1 | SNV | Missense_Mutation | rs368144967 | c.185N>A | p.Arg62Gln | p.R62Q | Q9UJC3 | protein_coding | deleterious(0.03) | probably_damaging(0.988) | TCGA-EY-A2OM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
HOOK1 | SNV | Missense_Mutation | rs781567088 | c.1009C>T | p.Arg337Cys | p.R337C | Q9UJC3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
HOOK1 | SNV | Missense_Mutation | novel | c.637N>T | p.Asp213Tyr | p.D213Y | Q9UJC3 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-PG-A914-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOOK1 | insertion | Frame_Shift_Ins | novel | c.918_919insTCAT | p.Asp307SerfsTer2 | p.D307Sfs*2 | Q9UJC3 | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
HOOK1 | insertion | Frame_Shift_Ins | novel | c.919_920insGACC | p.Asp307GlyfsTer5 | p.D307Gfs*5 | Q9UJC3 | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
HOOK1 | insertion | Frame_Shift_Ins | novel | c.1989dupA | p.Leu664ThrfsTer8 | p.L664Tfs*8 | Q9UJC3 | protein_coding | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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