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Gene: HNRNPK |
Gene summary for HNRNPK |
Gene summary. |
Gene information | Species | Human | Gene symbol | HNRNPK | Gene ID | 3190 |
Gene name | heterogeneous nuclear ribonucleoprotein K | |
Gene Alias | AUKS | |
Cytomap | 9q21.32 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | B4DUQ1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3190 | HNRNPK | GSM4909282 | Human | Breast | IDC | 3.67e-03 | 2.09e-01 | -0.0288 |
3190 | HNRNPK | GSM4909286 | Human | Breast | IDC | 5.24e-05 | -1.74e-01 | 0.1081 |
3190 | HNRNPK | GSM4909287 | Human | Breast | IDC | 7.23e-03 | 1.05e-01 | 0.2057 |
3190 | HNRNPK | GSM4909288 | Human | Breast | IDC | 3.87e-04 | -3.14e-02 | 0.0988 |
3190 | HNRNPK | GSM4909294 | Human | Breast | IDC | 7.45e-08 | -1.94e-01 | 0.2022 |
3190 | HNRNPK | GSM4909296 | Human | Breast | IDC | 3.61e-17 | -3.26e-01 | 0.1524 |
3190 | HNRNPK | GSM4909297 | Human | Breast | IDC | 3.52e-29 | -1.56e-01 | 0.1517 |
3190 | HNRNPK | GSM4909309 | Human | Breast | IDC | 8.35e-03 | -3.12e-01 | 0.0483 |
3190 | HNRNPK | GSM4909311 | Human | Breast | IDC | 2.30e-51 | -4.77e-01 | 0.1534 |
3190 | HNRNPK | GSM4909312 | Human | Breast | IDC | 1.45e-13 | 2.31e-02 | 0.1552 |
3190 | HNRNPK | GSM4909313 | Human | Breast | IDC | 3.16e-03 | -1.16e-01 | 0.0391 |
3190 | HNRNPK | GSM4909319 | Human | Breast | IDC | 2.33e-69 | -6.84e-01 | 0.1563 |
3190 | HNRNPK | GSM4909320 | Human | Breast | IDC | 6.73e-17 | -7.43e-01 | 0.1575 |
3190 | HNRNPK | GSM4909321 | Human | Breast | IDC | 2.85e-20 | -2.50e-01 | 0.1559 |
3190 | HNRNPK | brca2 | Human | Breast | Precancer | 8.78e-10 | 3.55e-01 | -0.024 |
3190 | HNRNPK | brca3 | Human | Breast | Precancer | 2.60e-20 | 4.14e-01 | -0.0263 |
3190 | HNRNPK | M1 | Human | Breast | IDC | 6.92e-03 | 2.74e-01 | 0.1577 |
3190 | HNRNPK | M2 | Human | Breast | IDC | 6.41e-09 | 2.81e-01 | 0.21 |
3190 | HNRNPK | NCCBC14 | Human | Breast | DCIS | 7.55e-17 | -4.39e-02 | 0.2021 |
3190 | HNRNPK | NCCBC2 | Human | Breast | DCIS | 9.82e-03 | -1.96e-01 | 0.1554 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00971939 | Breast | Precancer | intrinsic apoptotic signaling pathway | 59/1080 | 288/18723 | 8.07e-18 | 3.60e-15 | 59 |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:20012429 | Breast | Precancer | regulation of intrinsic apoptotic signaling pathway | 41/1080 | 164/18723 | 6.48e-16 | 2.31e-13 | 41 |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00480249 | Breast | Precancer | regulation of mRNA splicing, via spliceosome | 22/1080 | 101/18723 | 5.29e-08 | 3.18e-06 | 22 |
GO:19017969 | Breast | Precancer | regulation of signal transduction by p53 class mediator | 19/1080 | 93/18723 | 1.20e-06 | 4.60e-05 | 19 |
GO:19033118 | Breast | Precancer | regulation of mRNA metabolic process | 38/1080 | 288/18723 | 1.63e-06 | 5.97e-05 | 38 |
GO:00723319 | Breast | Precancer | signal transduction by p53 class mediator | 26/1080 | 163/18723 | 2.23e-06 | 7.76e-05 | 26 |
GO:00506848 | Breast | Precancer | regulation of mRNA processing | 23/1080 | 137/18723 | 3.49e-06 | 1.13e-04 | 23 |
GO:00723328 | Breast | Precancer | intrinsic apoptotic signaling pathway by p53 class mediator | 16/1080 | 76/18723 | 5.49e-06 | 1.63e-04 | 16 |
GO:00331199 | Breast | Precancer | negative regulation of RNA splicing | 9/1080 | 25/18723 | 6.03e-06 | 1.72e-04 | 9 |
GO:19022537 | Breast | Precancer | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 9/1080 | 29/18723 | 2.40e-05 | 5.53e-04 | 9 |
GO:19033129 | Breast | Precancer | negative regulation of mRNA metabolic process | 16/1080 | 92/18723 | 6.70e-05 | 1.35e-03 | 16 |
GO:00086308 | Breast | Precancer | intrinsic apoptotic signaling pathway in response to DNA damage | 16/1080 | 99/18723 | 1.65e-04 | 2.74e-03 | 16 |
GO:19021655 | Breast | Precancer | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 6/1080 | 16/18723 | 1.76e-04 | 2.87e-03 | 6 |
GO:00427718 | Breast | Precancer | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 9/1080 | 43/18723 | 6.51e-04 | 7.99e-03 | 9 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030408 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa052036 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0304013 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0520312 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0304023 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0520322 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0304033 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0520332 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0304043 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa0520341 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa0304053 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa052035 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPK | SNV | Missense_Mutation | novel | c.662N>A | p.Arg221His | p.R221H | P61978 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-55-6982-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD |
HNRNPK | SNV | Missense_Mutation | novel | c.580N>G | p.Leu194Val | p.L194V | P61978 | protein_coding | tolerated(0.15) | possibly_damaging(0.702) | TCGA-CN-5367-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
HNRNPK | SNV | Missense_Mutation | novel | c.805N>A | p.Gly269Ser | p.G269S | P61978 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HNRNPK | SNV | Missense_Mutation | novel | c.847A>G | p.Met283Val | p.M283V | P61978 | protein_coding | deleterious_low_confidence(0.05) | benign(0.015) | TCGA-F7-A623-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HNRNPK | insertion | In_Frame_Ins | novel | c.365_366insTCTTCCTGCTCGGCCTCAGACGCCCAC | p.Gln122delinsHisLeuProAlaArgProGlnThrProThr | p.Q122delinsHLPARPQTPT | P61978 | protein_coding | TCGA-P3-A6T8-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | ||
HNRNPK | SNV | Missense_Mutation | rs760176912 | c.892G>A | p.Gly298Ser | p.G298S | P61978 | protein_coding | tolerated(0.49) | benign(0.085) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPK | SNV | Missense_Mutation | c.1298N>T | p.Arg433Leu | p.R433L | P61978 | protein_coding | deleterious(0) | possibly_damaging(0.663) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
HNRNPK | SNV | Missense_Mutation | c.1102N>A | p.Gly368Arg | p.G368R | P61978 | protein_coding | tolerated(0.16) | benign(0.053) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPK | SNV | Missense_Mutation | c.1298G>A | p.Arg433Gln | p.R433Q | P61978 | protein_coding | tolerated(0.09) | benign(0.065) | TCGA-D7-8572-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HNRNPK | SNV | Missense_Mutation | novel | c.737N>C | p.Arg246Pro | p.R246P | P61978 | protein_coding | deleterious(0.02) | possibly_damaging(0.722) | TCGA-HU-8238-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | didox | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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