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Gene: HMGXB4 |
Gene summary for HMGXB4 |
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Gene information | Species | Human | Gene symbol | HMGXB4 | Gene ID | 10042 |
Gene name | HMG-box containing 4 | |
Gene Alias | HMG2L1 | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q7Z641 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10042 | HMGXB4 | LZE4T | Human | Esophagus | ESCC | 7.14e-16 | 3.12e-01 | 0.0811 |
10042 | HMGXB4 | LZE5T | Human | Esophagus | ESCC | 8.59e-04 | 3.47e-01 | 0.0514 |
10042 | HMGXB4 | LZE7T | Human | Esophagus | ESCC | 8.03e-16 | 7.06e-01 | 0.0667 |
10042 | HMGXB4 | LZE8T | Human | Esophagus | ESCC | 1.03e-11 | 2.48e-01 | 0.067 |
10042 | HMGXB4 | LZE20T | Human | Esophagus | ESCC | 1.87e-05 | 1.82e-01 | 0.0662 |
10042 | HMGXB4 | LZE22D1 | Human | Esophagus | HGIN | 1.28e-03 | 1.87e-01 | 0.0595 |
10042 | HMGXB4 | LZE22T | Human | Esophagus | ESCC | 5.44e-03 | 2.12e-01 | 0.068 |
10042 | HMGXB4 | LZE24T | Human | Esophagus | ESCC | 8.79e-18 | 3.64e-01 | 0.0596 |
10042 | HMGXB4 | LZE21T | Human | Esophagus | ESCC | 2.61e-05 | 4.01e-01 | 0.0655 |
10042 | HMGXB4 | LZE6T | Human | Esophagus | ESCC | 6.23e-09 | 2.28e-01 | 0.0845 |
10042 | HMGXB4 | P1T-E | Human | Esophagus | ESCC | 2.71e-19 | 7.82e-01 | 0.0875 |
10042 | HMGXB4 | P2T-E | Human | Esophagus | ESCC | 1.08e-28 | 6.04e-01 | 0.1177 |
10042 | HMGXB4 | P4T-E | Human | Esophagus | ESCC | 7.44e-28 | 4.55e-01 | 0.1323 |
10042 | HMGXB4 | P5T-E | Human | Esophagus | ESCC | 2.06e-17 | 3.40e-01 | 0.1327 |
10042 | HMGXB4 | P8T-E | Human | Esophagus | ESCC | 6.14e-28 | 5.23e-01 | 0.0889 |
10042 | HMGXB4 | P9T-E | Human | Esophagus | ESCC | 7.73e-25 | 4.79e-01 | 0.1131 |
10042 | HMGXB4 | P10T-E | Human | Esophagus | ESCC | 1.69e-40 | 7.40e-01 | 0.116 |
10042 | HMGXB4 | P11T-E | Human | Esophagus | ESCC | 1.16e-17 | 5.17e-01 | 0.1426 |
10042 | HMGXB4 | P12T-E | Human | Esophagus | ESCC | 1.39e-23 | 4.65e-01 | 0.1122 |
10042 | HMGXB4 | P15T-E | Human | Esophagus | ESCC | 1.87e-35 | 6.57e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003011116 | Esophagus | HGIN | regulation of Wnt signaling pathway | 65/2587 | 328/18723 | 1.53e-03 | 1.77e-02 | 65 |
GO:001605516 | Esophagus | HGIN | Wnt signaling pathway | 83/2587 | 444/18723 | 2.27e-03 | 2.33e-02 | 83 |
GO:000703416 | Esophagus | HGIN | vacuolar transport | 35/2587 | 157/18723 | 2.52e-03 | 2.51e-02 | 35 |
GO:019873816 | Esophagus | HGIN | cell-cell signaling by wnt | 83/2587 | 446/18723 | 2.58e-03 | 2.55e-02 | 83 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:00070419 | Esophagus | ESCC | lysosomal transport | 83/8552 | 114/18723 | 3.52e-09 | 7.41e-08 | 83 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:00083333 | Esophagus | ESCC | endosome to lysosome transport | 40/8552 | 55/18723 | 4.27e-05 | 3.42e-04 | 40 |
GO:00301788 | Esophagus | ESCC | negative regulation of Wnt signaling pathway | 97/8552 | 170/18723 | 1.81e-03 | 8.31e-03 | 97 |
GO:000703411 | Liver | Cirrhotic | vacuolar transport | 75/4634 | 157/18723 | 3.13e-10 | 1.53e-08 | 75 |
GO:000704111 | Liver | Cirrhotic | lysosomal transport | 50/4634 | 114/18723 | 6.15e-06 | 9.82e-05 | 50 |
GO:001605511 | Liver | Cirrhotic | Wnt signaling pathway | 150/4634 | 444/18723 | 9.75e-06 | 1.42e-04 | 150 |
GO:019873811 | Liver | Cirrhotic | cell-cell signaling by wnt | 150/4634 | 446/18723 | 1.28e-05 | 1.80e-04 | 150 |
GO:003011111 | Liver | Cirrhotic | regulation of Wnt signaling pathway | 112/4634 | 328/18723 | 7.57e-05 | 8.40e-04 | 112 |
GO:0008333 | Liver | Cirrhotic | endosome to lysosome transport | 24/4634 | 55/18723 | 1.67e-03 | 1.07e-02 | 24 |
GO:000703421 | Liver | HCC | vacuolar transport | 108/7958 | 157/18723 | 2.22e-11 | 8.69e-10 | 108 |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HMGXB4 | SNV | Missense_Mutation | c.117N>A | p.Asp39Glu | p.D39E | Q9UGU5 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HMGXB4 | SNV | Missense_Mutation | novel | c.1678N>A | p.Asp560Asn | p.D560N | Q9UGU5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-96-7544-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HMGXB4 | SNV | Missense_Mutation | novel | c.242A>T | p.Asp81Val | p.D81V | Q9UGU5 | protein_coding | deleterious(0) | possibly_damaging(0.878) | TCGA-NC-A5HK-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HMGXB4 | SNV | Missense_Mutation | novel | c.1197N>C | p.Glu399Asp | p.E399D | Q9UGU5 | protein_coding | tolerated(0.88) | benign(0.005) | TCGA-CV-5978-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
HMGXB4 | SNV | Missense_Mutation | novel | c.557A>G | p.Glu186Gly | p.E186G | Q9UGU5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CV-7433-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
HMGXB4 | SNV | Missense_Mutation | novel | c.1458G>C | p.Met486Ile | p.M486I | Q9UGU5 | protein_coding | tolerated(0.54) | benign(0) | TCGA-HD-A6HZ-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HMGXB4 | SNV | Missense_Mutation | c.323N>T | p.Thr108Ile | p.T108I | Q9UGU5 | protein_coding | deleterious(0) | possibly_damaging(0.61) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HMGXB4 | SNV | Missense_Mutation | c.796N>T | p.Gly266Cys | p.G266C | Q9UGU5 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.541) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
HMGXB4 | SNV | Missense_Mutation | c.1273N>G | p.Ile425Val | p.I425V | Q9UGU5 | protein_coding | tolerated(0.1) | probably_damaging(0.987) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
HMGXB4 | SNV | Missense_Mutation | rs762501665 | c.502N>G | p.Lys168Glu | p.K168E | Q9UGU5 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.682) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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