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Gene: HJURP |
Gene summary for HJURP |
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Gene information | Species | Human | Gene symbol | HJURP | Gene ID | 55355 |
Gene name | Holliday junction recognition protein | |
Gene Alias | FAKTS | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | Q8NCD3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55355 | HJURP | P2T-E | Human | Esophagus | ESCC | 8.84e-05 | 2.38e-01 | 0.1177 |
55355 | HJURP | P5T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.85e-01 | 0.1327 |
55355 | HJURP | P10T-E | Human | Esophagus | ESCC | 4.31e-06 | 2.75e-01 | 0.116 |
55355 | HJURP | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 2.38e-01 | 0.1278 |
55355 | HJURP | P21T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.63e-01 | 0.1617 |
55355 | HJURP | P24T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.14e-01 | 0.1287 |
55355 | HJURP | P28T-E | Human | Esophagus | ESCC | 3.50e-02 | 9.61e-02 | 0.1149 |
55355 | HJURP | P31T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.44e-01 | 0.1251 |
55355 | HJURP | P32T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.81e-01 | 0.1666 |
55355 | HJURP | P49T-E | Human | Esophagus | ESCC | 6.53e-04 | 4.34e-01 | 0.1768 |
55355 | HJURP | P52T-E | Human | Esophagus | ESCC | 4.41e-07 | 2.37e-01 | 0.1555 |
55355 | HJURP | P76T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.75e-01 | 0.1207 |
55355 | HJURP | P79T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.57e-01 | 0.1154 |
55355 | HJURP | P83T-E | Human | Esophagus | ESCC | 3.65e-06 | 2.70e-01 | 0.1738 |
55355 | HJURP | P89T-E | Human | Esophagus | ESCC | 4.36e-04 | 4.37e-01 | 0.1752 |
55355 | HJURP | P91T-E | Human | Esophagus | ESCC | 8.74e-05 | 7.47e-01 | 0.1828 |
55355 | HJURP | P107T-E | Human | Esophagus | ESCC | 1.10e-10 | 3.48e-01 | 0.171 |
55355 | HJURP | P130T-E | Human | Esophagus | ESCC | 1.76e-12 | 5.37e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0051101111 | Esophagus | ESCC | regulation of DNA binding | 84/8552 | 118/18723 | 1.64e-08 | 3.21e-07 | 84 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00345081 | Esophagus | ESCC | centromere complex assembly | 25/8552 | 30/18723 | 2.45e-05 | 2.09e-04 | 25 |
GO:0031055 | Esophagus | ESCC | chromatin remodeling at centromere | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:0043486 | Esophagus | ESCC | histone exchange | 16/8552 | 22/18723 | 9.46e-03 | 3.28e-02 | 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HJURP | SNV | Missense_Mutation | rs750138498 | c.1327C>T | p.Arg443Trp | p.R443W | Q8NCD3 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-EY-A1GO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
HJURP | SNV | Missense_Mutation | rs368958261 | c.1727N>A | p.Arg576His | p.R576H | Q8NCD3 | protein_coding | tolerated(0.12) | benign(0.02) | TCGA-EY-A548-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HJURP | SNV | Missense_Mutation | c.1916N>G | p.Leu639Trp | p.L639W | Q8NCD3 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-DD-A39V-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HJURP | SNV | Missense_Mutation | c.951N>C | p.Gln317His | p.Q317H | Q8NCD3 | protein_coding | tolerated(0.17) | benign(0.036) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
HJURP | SNV | Missense_Mutation | c.1726N>A | p.Arg576Ser | p.R576S | Q8NCD3 | protein_coding | deleterious(0.05) | benign(0.224) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
HJURP | SNV | Missense_Mutation | c.43N>T | p.Asp15Tyr | p.D15Y | Q8NCD3 | protein_coding | deleterious(0) | benign(0.188) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
HJURP | SNV | Missense_Mutation | c.1135N>A | p.Val379Met | p.V379M | Q8NCD3 | protein_coding | tolerated(0.22) | benign(0.22) | TCGA-55-7914-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
HJURP | SNV | Missense_Mutation | rs201325476 | c.24N>C | p.Met8Ile | p.M8I | Q8NCD3 | protein_coding | deleterious(0.01) | benign(0.089) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
HJURP | SNV | Missense_Mutation | rs749671993 | c.1055N>T | p.Gly352Val | p.G352V | Q8NCD3 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HJURP | SNV | Missense_Mutation | c.1054N>T | p.Gly352Cys | p.G352C | Q8NCD3 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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