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Gene: HEATR1 |
Gene summary for HEATR1 |
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Gene information | Species | Human | Gene symbol | HEATR1 | Gene ID | 55127 |
Gene name | HEAT repeat containing 1 | |
Gene Alias | BAP28 | |
Cytomap | 1q43 | |
Gene Type | protein-coding | GO ID | GO:0000462 | UniProtAcc | A2VDI1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55127 | HEATR1 | LZE4T | Human | Esophagus | ESCC | 1.25e-02 | 1.18e-01 | 0.0811 |
55127 | HEATR1 | LZE7T | Human | Esophagus | ESCC | 1.04e-09 | 4.46e-01 | 0.0667 |
55127 | HEATR1 | LZE20T | Human | Esophagus | ESCC | 4.53e-02 | 5.59e-02 | 0.0662 |
55127 | HEATR1 | LZE24T | Human | Esophagus | ESCC | 1.17e-07 | 2.04e-01 | 0.0596 |
55127 | HEATR1 | P1T-E | Human | Esophagus | ESCC | 1.54e-09 | 3.40e-01 | 0.0875 |
55127 | HEATR1 | P2T-E | Human | Esophagus | ESCC | 3.33e-20 | 3.39e-01 | 0.1177 |
55127 | HEATR1 | P4T-E | Human | Esophagus | ESCC | 7.54e-09 | 1.79e-01 | 0.1323 |
55127 | HEATR1 | P5T-E | Human | Esophagus | ESCC | 4.88e-16 | 2.45e-01 | 0.1327 |
55127 | HEATR1 | P8T-E | Human | Esophagus | ESCC | 6.21e-14 | 2.34e-01 | 0.0889 |
55127 | HEATR1 | P9T-E | Human | Esophagus | ESCC | 1.76e-09 | 2.15e-01 | 0.1131 |
55127 | HEATR1 | P10T-E | Human | Esophagus | ESCC | 6.97e-18 | 3.00e-01 | 0.116 |
55127 | HEATR1 | P11T-E | Human | Esophagus | ESCC | 3.10e-04 | 2.05e-01 | 0.1426 |
55127 | HEATR1 | P12T-E | Human | Esophagus | ESCC | 3.70e-06 | 1.07e-01 | 0.1122 |
55127 | HEATR1 | P15T-E | Human | Esophagus | ESCC | 4.17e-17 | 3.40e-01 | 0.1149 |
55127 | HEATR1 | P16T-E | Human | Esophagus | ESCC | 6.15e-14 | 2.53e-01 | 0.1153 |
55127 | HEATR1 | P17T-E | Human | Esophagus | ESCC | 1.07e-04 | 2.40e-01 | 0.1278 |
55127 | HEATR1 | P20T-E | Human | Esophagus | ESCC | 1.25e-14 | 2.83e-01 | 0.1124 |
55127 | HEATR1 | P21T-E | Human | Esophagus | ESCC | 1.36e-24 | 4.15e-01 | 0.1617 |
55127 | HEATR1 | P22T-E | Human | Esophagus | ESCC | 1.00e-14 | 2.65e-01 | 0.1236 |
55127 | HEATR1 | P23T-E | Human | Esophagus | ESCC | 3.39e-19 | 4.34e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:00004623 | Esophagus | ESCC | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 32/8552 | 37/18723 | 2.96e-07 | 4.23e-06 | 32 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:00063564 | Esophagus | ESCC | regulation of transcription by RNA polymerase I | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
GO:00459432 | Esophagus | ESCC | positive regulation of transcription by RNA polymerase I | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:2000234 | Esophagus | ESCC | positive regulation of rRNA processing | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:004227422 | Liver | HCC | ribosomal small subunit biogenesis | 65/7958 | 73/18723 | 1.09e-16 | 9.92e-15 | 65 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HEATR1 | SNV | Missense_Mutation | c.6063G>A | p.Met2021Ile | p.M2021I | Q9H583 | protein_coding | tolerated(0.3) | benign(0.013) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HEATR1 | SNV | Missense_Mutation | c.2080G>A | p.Glu694Lys | p.E694K | Q9H583 | protein_coding | deleterious(0.04) | benign(0.23) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
HEATR1 | SNV | Missense_Mutation | c.1640A>G | p.His547Arg | p.H547R | Q9H583 | protein_coding | tolerated(0.38) | benign(0.007) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HEATR1 | SNV | Missense_Mutation | c.5689A>G | p.Ile1897Val | p.I1897V | Q9H583 | protein_coding | tolerated(0.08) | benign(0.026) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HEATR1 | SNV | Missense_Mutation | c.956A>G | p.Lys319Arg | p.K319R | Q9H583 | protein_coding | tolerated(0.34) | benign(0.25) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HEATR1 | SNV | Missense_Mutation | novel | c.5555N>C | p.Ile1852Thr | p.I1852T | Q9H583 | protein_coding | deleterious(0) | benign(0.343) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
HEATR1 | SNV | Missense_Mutation | c.2345N>T | p.Ala782Val | p.A782V | Q9H583 | protein_coding | tolerated(0.37) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
HEATR1 | SNV | Missense_Mutation | c.6313G>A | p.Glu2105Lys | p.E2105K | Q9H583 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HEATR1 | SNV | Missense_Mutation | c.5275A>G | p.Ser1759Gly | p.S1759G | Q9H583 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HEATR1 | SNV | Missense_Mutation | c.94N>C | p.Asp32His | p.D32H | Q9H583 | protein_coding | deleterious(0.03) | benign(0.096) | TCGA-D5-6532-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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