GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485457 | Liver | NAFLD | response to steroid hormone | 75/1882 | 339/18723 | 3.44e-11 | 1.12e-08 | 75 |
GO:00165703 | Liver | NAFLD | histone modification | 90/1882 | 463/18723 | 5.74e-10 | 1.28e-07 | 90 |
GO:00713836 | Liver | NAFLD | cellular response to steroid hormone stimulus | 48/1882 | 204/18723 | 1.50e-08 | 1.83e-06 | 48 |
GO:00316477 | Liver | NAFLD | regulation of protein stability | 61/1882 | 298/18723 | 5.00e-08 | 4.71e-06 | 61 |
GO:00181055 | Liver | NAFLD | peptidyl-serine phosphorylation | 63/1882 | 315/18723 | 7.45e-08 | 6.60e-06 | 63 |
GO:00002095 | Liver | NAFLD | protein polyubiquitination | 51/1882 | 236/18723 | 1.04e-07 | 8.10e-06 | 51 |
GO:00305226 | Liver | NAFLD | intracellular receptor signaling pathway | 55/1882 | 265/18723 | 1.39e-07 | 1.03e-05 | 55 |
GO:00160495 | Liver | NAFLD | cell growth | 85/1882 | 482/18723 | 1.75e-07 | 1.25e-05 | 85 |
GO:00458617 | Liver | NAFLD | negative regulation of proteolysis | 66/1882 | 351/18723 | 4.02e-07 | 2.58e-05 | 66 |
GO:00182094 | Liver | NAFLD | peptidyl-serine modification | 64/1882 | 338/18723 | 4.65e-07 | 2.89e-05 | 64 |
GO:00069797 | Liver | NAFLD | response to oxidative stress | 78/1882 | 446/18723 | 7.85e-07 | 4.29e-05 | 78 |
GO:19029037 | Liver | NAFLD | regulation of supramolecular fiber organization | 66/1882 | 383/18723 | 8.97e-06 | 2.96e-04 | 66 |
GO:0018205 | Liver | NAFLD | peptidyl-lysine modification | 65/1882 | 376/18723 | 9.42e-06 | 3.02e-04 | 65 |
GO:00105065 | Liver | NAFLD | regulation of autophagy | 57/1882 | 317/18723 | 1.00e-05 | 3.18e-04 | 57 |
GO:00097556 | Liver | NAFLD | hormone-mediated signaling pathway | 39/1882 | 190/18723 | 1.15e-05 | 3.58e-04 | 39 |
GO:00485884 | Liver | NAFLD | developmental cell growth | 45/1882 | 234/18723 | 1.50e-05 | 4.38e-04 | 45 |
GO:00163585 | Liver | NAFLD | dendrite development | 43/1882 | 243/18723 | 1.70e-04 | 3.07e-03 | 43 |
GO:00434016 | Liver | NAFLD | steroid hormone mediated signaling pathway | 28/1882 | 136/18723 | 1.78e-04 | 3.14e-03 | 28 |
GO:00065153 | Liver | NAFLD | protein quality control for misfolded or incompletely synthesized proteins | 10/1882 | 28/18723 | 2.46e-04 | 4.09e-03 | 10 |
GO:00488133 | Liver | NAFLD | dendrite morphogenesis | 29/1882 | 146/18723 | 2.63e-04 | 4.26e-03 | 29 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HDAC6 | MYOFIB | Colorectum | ADJ | OTUD6B-AS1,COL13A1,RNF170, etc. | 3.26e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HDAC6 | MYOFIB | Colorectum | FAP | OTUD6B-AS1,COL13A1,RNF170, etc. | 2.54e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_FAP/regulons_activity_in_dotplot.png) |
HDAC6 | BAS | Endometrium | ADJ | MINDY2,ZNF662,TAF1C, etc. | 6.21e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HDAC6 | iATC | Thyroid | Healthy | MRPL36,NSRP1,MVB12A, etc. | 6.35e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDAC6 | SNV | Missense_Mutation | novel | c.2329A>G | p.Ile777Val | p.I777V | Q9UBN7 | protein_coding | tolerated(0.51) | benign(0.021) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | novel | c.2239N>A | p.Asp747Asn | p.D747N | Q9UBN7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
HDAC6 | SNV | Missense_Mutation | novel | c.2559N>T | p.Lys853Asn | p.K853N | Q9UBN7 | protein_coding | tolerated(0.35) | benign(0.107) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | novel | c.1816N>T | p.Arg606Cys | p.R606C | Q9UBN7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
HDAC6 | SNV | Missense_Mutation | novel | c.3035N>T | p.Ala1012Val | p.A1012V | Q9UBN7 | protein_coding | tolerated(0.41) | benign(0.003) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | novel | c.2164N>A | p.Leu722Met | p.L722M | Q9UBN7 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | | c.1924C>T | p.Arg642Trp | p.R642W | Q9UBN7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | | c.853C>A | p.Pro285Thr | p.P285T | Q9UBN7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | | c.3512C>T | p.Pro1171Leu | p.P1171L | Q9UBN7 | protein_coding | tolerated(0.13) | probably_damaging(0.99) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | | c.3542N>T | p.Ala1181Val | p.A1181V | Q9UBN7 | protein_coding | tolerated(1) | benign(0.007) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID28092474-Compound-32i | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID29671355-Compound-28 | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID29671355-Compound-9 | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID29671355-Compound-14 | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PRACINOSTAT | PRACINOSTAT | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID28092474-Compound-33p | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | BELINOSTAT | BELINOSTAT | 25937017 |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | inhibitor | 187051807 | SCRIPTAID | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | inhibitor | 187051792 | PANOBINOSTAT | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | inhibitor | 249565599 | | |