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Gene: HDAC2 |
Gene summary for HDAC2 |
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Gene information | Species | Human | Gene symbol | HDAC2 | Gene ID | 3066 |
Gene name | histone deacetylase 2 | |
Gene Alias | HD2 | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q92769 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3066 | HDAC2 | GSM4909281 | Human | Breast | IDC | 3.44e-02 | 2.93e-01 | 0.21 |
3066 | HDAC2 | GSM4909285 | Human | Breast | IDC | 9.19e-30 | 6.25e-01 | 0.21 |
3066 | HDAC2 | GSM4909286 | Human | Breast | IDC | 6.81e-04 | 3.76e-01 | 0.1081 |
3066 | HDAC2 | GSM4909287 | Human | Breast | IDC | 6.52e-06 | 3.19e-01 | 0.2057 |
3066 | HDAC2 | GSM4909293 | Human | Breast | IDC | 3.45e-05 | 3.26e-01 | 0.1581 |
3066 | HDAC2 | GSM4909296 | Human | Breast | IDC | 5.60e-13 | -2.83e-01 | 0.1524 |
3066 | HDAC2 | GSM4909297 | Human | Breast | IDC | 1.69e-11 | -1.28e-01 | 0.1517 |
3066 | HDAC2 | GSM4909302 | Human | Breast | IDC | 8.95e-09 | -2.84e-01 | 0.1545 |
3066 | HDAC2 | GSM4909311 | Human | Breast | IDC | 2.08e-21 | -2.20e-01 | 0.1534 |
3066 | HDAC2 | GSM4909312 | Human | Breast | IDC | 1.46e-09 | -9.16e-02 | 0.1552 |
3066 | HDAC2 | GSM4909319 | Human | Breast | IDC | 5.75e-26 | -2.92e-01 | 0.1563 |
3066 | HDAC2 | GSM4909320 | Human | Breast | IDC | 1.46e-06 | -2.79e-01 | 0.1575 |
3066 | HDAC2 | GSM4909321 | Human | Breast | IDC | 2.26e-12 | -2.26e-01 | 0.1559 |
3066 | HDAC2 | brca3 | Human | Breast | Precancer | 3.44e-04 | 3.18e-01 | -0.0263 |
3066 | HDAC2 | M2 | Human | Breast | IDC | 1.30e-10 | 5.28e-01 | 0.21 |
3066 | HDAC2 | NCCBC14 | Human | Breast | DCIS | 4.60e-09 | -2.16e-02 | 0.2021 |
3066 | HDAC2 | NCCBC5 | Human | Breast | DCIS | 4.33e-10 | -7.12e-02 | 0.2046 |
3066 | HDAC2 | NCCBC6 | Human | Breast | DCIS | 2.73e-06 | 5.13e-01 | 0.2095 |
3066 | HDAC2 | P1 | Human | Breast | IDC | 1.01e-13 | -1.51e-01 | 0.1527 |
3066 | HDAC2 | P2 | Human | Breast | IDC | 2.24e-05 | 2.71e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00704829 | Breast | Precancer | response to oxygen levels | 55/1080 | 347/18723 | 7.47e-12 | 1.11e-09 | 55 |
GO:00621979 | Breast | Precancer | cellular response to chemical stress | 51/1080 | 337/18723 | 2.40e-10 | 2.34e-08 | 51 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:00345999 | Breast | Precancer | cellular response to oxidative stress | 42/1080 | 288/18723 | 2.78e-08 | 1.79e-06 | 42 |
GO:00425429 | Breast | Precancer | response to hydrogen peroxide | 26/1080 | 146/18723 | 2.52e-07 | 1.26e-05 | 26 |
GO:00511019 | Breast | Precancer | regulation of DNA binding | 22/1080 | 118/18723 | 9.28e-07 | 3.71e-05 | 22 |
GO:00510989 | Breast | Precancer | regulation of binding | 44/1080 | 363/18723 | 2.59e-06 | 8.65e-05 | 44 |
GO:00092667 | Breast | Precancer | response to temperature stimulus | 27/1080 | 178/18723 | 3.85e-06 | 1.21e-04 | 27 |
GO:00018196 | Breast | Precancer | positive regulation of cytokine production | 52/1080 | 467/18723 | 4.18e-06 | 1.29e-04 | 52 |
GO:00022378 | Breast | Precancer | response to molecule of bacterial origin | 43/1080 | 363/18723 | 6.05e-06 | 1.72e-04 | 43 |
GO:00346059 | Breast | Precancer | cellular response to heat | 15/1080 | 69/18723 | 7.08e-06 | 1.95e-04 | 15 |
GO:00324968 | Breast | Precancer | response to lipopolysaccharide | 41/1080 | 343/18723 | 7.94e-06 | 2.17e-04 | 41 |
GO:00346149 | Breast | Precancer | cellular response to reactive oxygen species | 23/1080 | 155/18723 | 2.82e-05 | 6.31e-04 | 23 |
GO:00094088 | Breast | Precancer | response to heat | 18/1080 | 110/18723 | 5.57e-05 | 1.15e-03 | 18 |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00420633 | Breast | Precancer | gliogenesis | 33/1080 | 301/18723 | 3.06e-04 | 4.40e-03 | 33 |
GO:00094108 | Breast | Precancer | response to xenobiotic stimulus | 45/1080 | 462/18723 | 4.17e-04 | 5.56e-03 | 45 |
GO:00100013 | Breast | Precancer | glial cell differentiation | 25/1080 | 225/18723 | 1.29e-03 | 1.37e-02 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0516918 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa05031 | Breast | Precancer | Amphetamine addiction | 14/684 | 69/8465 | 1.05e-03 | 7.35e-03 | 5.63e-03 | 14 |
hsa052036 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0516919 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa050311 | Breast | Precancer | Amphetamine addiction | 14/684 | 69/8465 | 1.05e-03 | 7.35e-03 | 5.63e-03 | 14 |
hsa0520312 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0501623 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0516922 | Breast | IDC | Epstein-Barr virus infection | 45/867 | 202/8465 | 3.16e-07 | 6.05e-06 | 4.52e-06 | 45 |
hsa050312 | Breast | IDC | Amphetamine addiction | 18/867 | 69/8465 | 1.42e-04 | 1.36e-03 | 1.01e-03 | 18 |
hsa0491916 | Breast | IDC | Thyroid hormone signaling pathway | 23/867 | 121/8465 | 2.45e-03 | 1.69e-02 | 1.27e-02 | 23 |
hsa0520322 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0522010 | Breast | IDC | Chronic myeloid leukemia | 15/867 | 76/8465 | 9.24e-03 | 4.37e-02 | 3.27e-02 | 15 |
hsa0501633 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0516932 | Breast | IDC | Epstein-Barr virus infection | 45/867 | 202/8465 | 3.16e-07 | 6.05e-06 | 4.52e-06 | 45 |
hsa050313 | Breast | IDC | Amphetamine addiction | 18/867 | 69/8465 | 1.42e-04 | 1.36e-03 | 1.01e-03 | 18 |
hsa0491917 | Breast | IDC | Thyroid hormone signaling pathway | 23/867 | 121/8465 | 2.45e-03 | 1.69e-02 | 1.27e-02 | 23 |
hsa0520332 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0522013 | Breast | IDC | Chronic myeloid leukemia | 15/867 | 76/8465 | 9.24e-03 | 4.37e-02 | 3.27e-02 | 15 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDAC2 | insertion | Frame_Shift_Ins | novel | c.430_431insG | p.Lys144ArgfsTer12 | p.K144Rfs*12 | Q92769 | protein_coding | TCGA-KK-A59X-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | leuprolide | PD | ||
HDAC2 | insertion | Nonsense_Mutation | novel | c.429_430insTAATATAGAAAGCCTAGATTGCTTTGA | p.Ala143_Lys144insTer | p.A143_K144ins* | Q92769 | protein_coding | TCGA-KK-A59X-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | leuprolide | PD | ||
HDAC2 | SNV | Missense_Mutation | c.917T>A | p.Ile306Asn | p.I306N | Q92769 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HDAC2 | SNV | Missense_Mutation | novel | c.529N>A | p.Asp177Asn | p.D177N | Q92769 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDAC2 | SNV | Missense_Mutation | novel | c.140G>A | p.Gly47Asp | p.G47D | Q92769 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-VQ-A8DU-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
HDAC2 | SNV | Missense_Mutation | novel | c.750G>T | p.Met250Ile | p.M250I | Q92769 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-EM-A2CN-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | 2-ENE-VALPROATE | CHEMBL117487 | 17566732 | |
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | inhibitor | 187051807 | SCRIPTAID | |
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | inhibitor | BELINOSTAT | BELINOSTAT | |
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | inhibitor | 187051797 | APICIDIN | |
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | PAZOPANIB | PAZOPANIB | 28221861 | |
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | PRACINOSTAT | PRACINOSTAT | ||
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | inhibitor | 187051798 | BELINOSTAT | |
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | inhibitor | SODIUM PHENYLBUTYRATE | ||
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | VORINOSTAT | VORINOSTAT | 24694055,19344175,19966789,26211462,23622981,22260166,17447750,20491440,21548582,24074025,23672185,19084294 | |
3066 | HDAC2 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, TRANSCRIPTION FACTOR | PANOBINOSTAT | PANOBINOSTAT |
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