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Gene: HAUS5 |
Gene summary for HAUS5 |
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Gene information | Species | Human | Gene symbol | HAUS5 | Gene ID | 23354 |
Gene name | HAUS augmin like complex subunit 5 | |
Gene Alias | KIAA0841 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O94927 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23354 | HAUS5 | LZE24T | Human | Esophagus | ESCC | 4.34e-04 | 1.87e-01 | 0.0596 |
23354 | HAUS5 | P1T-E | Human | Esophagus | ESCC | 6.31e-04 | 3.47e-01 | 0.0875 |
23354 | HAUS5 | P2T-E | Human | Esophagus | ESCC | 2.57e-19 | 3.40e-01 | 0.1177 |
23354 | HAUS5 | P4T-E | Human | Esophagus | ESCC | 1.77e-10 | 2.36e-01 | 0.1323 |
23354 | HAUS5 | P5T-E | Human | Esophagus | ESCC | 4.79e-07 | 1.34e-01 | 0.1327 |
23354 | HAUS5 | P8T-E | Human | Esophagus | ESCC | 3.16e-13 | 2.32e-01 | 0.0889 |
23354 | HAUS5 | P9T-E | Human | Esophagus | ESCC | 3.93e-05 | 1.71e-01 | 0.1131 |
23354 | HAUS5 | P10T-E | Human | Esophagus | ESCC | 2.19e-16 | 3.20e-01 | 0.116 |
23354 | HAUS5 | P12T-E | Human | Esophagus | ESCC | 3.58e-10 | 1.70e-01 | 0.1122 |
23354 | HAUS5 | P15T-E | Human | Esophagus | ESCC | 1.60e-07 | 2.34e-01 | 0.1149 |
23354 | HAUS5 | P16T-E | Human | Esophagus | ESCC | 2.25e-06 | 1.51e-01 | 0.1153 |
23354 | HAUS5 | P17T-E | Human | Esophagus | ESCC | 4.76e-10 | 3.55e-01 | 0.1278 |
23354 | HAUS5 | P20T-E | Human | Esophagus | ESCC | 2.45e-06 | 1.90e-01 | 0.1124 |
23354 | HAUS5 | P21T-E | Human | Esophagus | ESCC | 4.07e-02 | 6.97e-02 | 0.1617 |
23354 | HAUS5 | P22T-E | Human | Esophagus | ESCC | 9.52e-04 | 1.30e-01 | 0.1236 |
23354 | HAUS5 | P23T-E | Human | Esophagus | ESCC | 8.61e-11 | 2.52e-01 | 0.108 |
23354 | HAUS5 | P24T-E | Human | Esophagus | ESCC | 5.40e-06 | 1.51e-01 | 0.1287 |
23354 | HAUS5 | P26T-E | Human | Esophagus | ESCC | 8.85e-10 | 1.83e-01 | 0.1276 |
23354 | HAUS5 | P27T-E | Human | Esophagus | ESCC | 7.55e-16 | 2.51e-01 | 0.1055 |
23354 | HAUS5 | P28T-E | Human | Esophagus | ESCC | 1.92e-07 | 1.83e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:00512256 | Esophagus | ESCC | spindle assembly | 85/8552 | 117/18723 | 2.72e-09 | 5.98e-08 | 85 |
GO:00070982 | Esophagus | ESCC | centrosome cycle | 85/8552 | 130/18723 | 4.41e-06 | 4.69e-05 | 85 |
GO:00310233 | Esophagus | ESCC | microtubule organizing center organization | 92/8552 | 143/18723 | 5.04e-06 | 5.31e-05 | 92 |
GO:000705111 | Liver | HCC | spindle organization | 116/7958 | 184/18723 | 1.40e-08 | 3.40e-07 | 116 |
GO:005122511 | Liver | HCC | spindle assembly | 75/7958 | 117/18723 | 1.92e-06 | 2.67e-05 | 75 |
GO:0031023 | Liver | HCC | microtubule organizing center organization | 82/7958 | 143/18723 | 2.38e-04 | 1.79e-03 | 82 |
GO:0007098 | Liver | HCC | centrosome cycle | 75/7958 | 130/18723 | 3.33e-04 | 2.34e-03 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HAUS5 | SNV | Missense_Mutation | c.1570C>A | p.Leu524Ile | p.L524I | O94927 | protein_coding | deleterious(0.03) | benign(0.009) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HAUS5 | SNV | Missense_Mutation | rs750360328 | c.1334N>A | p.Arg445His | p.R445H | O94927 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-D1-A160-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HAUS5 | SNV | Missense_Mutation | novel | c.98N>A | p.Arg33Lys | p.R33K | O94927 | protein_coding | tolerated(0.12) | probably_damaging(0.971) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
HAUS5 | SNV | Missense_Mutation | novel | c.675N>T | p.Gln225His | p.Q225H | O94927 | protein_coding | deleterious(0.03) | benign(0.015) | TCGA-DF-A2L0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
HAUS5 | SNV | Missense_Mutation | novel | c.227N>A | p.Arg76Gln | p.R76Q | O94927 | protein_coding | tolerated(0.17) | benign(0.186) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HAUS5 | SNV | Missense_Mutation | c.1573N>A | p.Leu525Met | p.L525M | O94927 | protein_coding | deleterious(0) | possibly_damaging(0.779) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HAUS5 | SNV | Missense_Mutation | novel | c.1036N>T | p.Leu346Phe | p.L346F | O94927 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
HAUS5 | deletion | Frame_Shift_Del | novel | c.714delN | p.Pro240GlnfsTer73 | p.P240Qfs*73 | O94927 | protein_coding | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | ||
HAUS5 | deletion | Frame_Shift_Del | novel | c.714delN | p.Pro240GlnfsTer73 | p.P240Qfs*73 | O94927 | protein_coding | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | ||
HAUS5 | deletion | Frame_Shift_Del | novel | c.613delN | p.Gln206ArgfsTer23 | p.Q206Rfs*23 | O94927 | protein_coding | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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