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Gene: GTPBP3 |
Gene summary for GTPBP3 |
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Gene information | Species | Human | Gene symbol | GTPBP3 | Gene ID | 84705 |
Gene name | GTP binding protein 3, mitochondrial | |
Gene Alias | COXPD23 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | B7Z563 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84705 | GTPBP3 | LZE7T | Human | Esophagus | ESCC | 6.77e-06 | 3.71e-01 | 0.0667 |
84705 | GTPBP3 | LZE24T | Human | Esophagus | ESCC | 8.16e-11 | 2.63e-01 | 0.0596 |
84705 | GTPBP3 | LZE21T | Human | Esophagus | ESCC | 7.57e-05 | 4.00e-01 | 0.0655 |
84705 | GTPBP3 | P2T-E | Human | Esophagus | ESCC | 1.93e-13 | 2.01e-01 | 0.1177 |
84705 | GTPBP3 | P4T-E | Human | Esophagus | ESCC | 8.89e-11 | 2.99e-01 | 0.1323 |
84705 | GTPBP3 | P5T-E | Human | Esophagus | ESCC | 9.54e-23 | 4.46e-01 | 0.1327 |
84705 | GTPBP3 | P8T-E | Human | Esophagus | ESCC | 9.95e-13 | 2.98e-01 | 0.0889 |
84705 | GTPBP3 | P9T-E | Human | Esophagus | ESCC | 1.23e-10 | 2.62e-01 | 0.1131 |
84705 | GTPBP3 | P10T-E | Human | Esophagus | ESCC | 2.58e-19 | 3.81e-01 | 0.116 |
84705 | GTPBP3 | P11T-E | Human | Esophagus | ESCC | 3.64e-04 | 2.79e-01 | 0.1426 |
84705 | GTPBP3 | P12T-E | Human | Esophagus | ESCC | 4.18e-17 | 3.18e-01 | 0.1122 |
84705 | GTPBP3 | P15T-E | Human | Esophagus | ESCC | 7.13e-11 | 2.45e-01 | 0.1149 |
84705 | GTPBP3 | P16T-E | Human | Esophagus | ESCC | 8.82e-18 | 2.87e-01 | 0.1153 |
84705 | GTPBP3 | P20T-E | Human | Esophagus | ESCC | 1.23e-13 | 3.51e-01 | 0.1124 |
84705 | GTPBP3 | P21T-E | Human | Esophagus | ESCC | 5.64e-12 | 2.64e-01 | 0.1617 |
84705 | GTPBP3 | P22T-E | Human | Esophagus | ESCC | 8.38e-13 | 1.81e-01 | 0.1236 |
84705 | GTPBP3 | P23T-E | Human | Esophagus | ESCC | 3.61e-14 | 3.27e-01 | 0.108 |
84705 | GTPBP3 | P24T-E | Human | Esophagus | ESCC | 5.89e-11 | 2.71e-01 | 0.1287 |
84705 | GTPBP3 | P26T-E | Human | Esophagus | ESCC | 3.04e-12 | 3.41e-01 | 0.1276 |
84705 | GTPBP3 | P27T-E | Human | Esophagus | ESCC | 3.36e-15 | 3.38e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
GO:0001510 | Liver | HCC | RNA methylation | 53/7958 | 83/18723 | 6.96e-05 | 6.29e-04 | 53 |
GO:0030488 | Liver | HCC | tRNA methylation | 29/7958 | 41/18723 | 2.38e-04 | 1.79e-03 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTPBP3 | SNV | Missense_Mutation | novel | c.86N>T | p.Ala29Val | p.A29V | Q969Y2 | protein_coding | tolerated(0.48) | benign(0.001) | TCGA-85-8049-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GTPBP3 | deletion | Frame_Shift_Del | novel | c.1238_1257delNNNNNNNNNNNNNNNNNNNN | p.Glu414Ter | p.E414* | Q969Y2 | protein_coding | TCGA-85-6561-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | ||
GTPBP3 | SNV | Missense_Mutation | novel | c.1375N>G | p.Pro459Ala | p.P459A | Q969Y2 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-XJ-A83F-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
GTPBP3 | SNV | Missense_Mutation | c.907N>T | p.Arg303Trp | p.R303W | Q969Y2 | protein_coding | deleterious(0) | possibly_damaging(0.854) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP3 | SNV | Missense_Mutation | c.1473N>T | p.Glu491Asp | p.E491D | Q969Y2 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP3 | SNV | Missense_Mutation | c.1030N>A | p.Gly344Arg | p.G344R | Q969Y2 | protein_coding | tolerated(0.05) | probably_damaging(0.967) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GTPBP3 | SNV | Missense_Mutation | c.625N>A | p.Gly209Ser | p.G209S | Q969Y2 | protein_coding | tolerated(1) | benign(0.015) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GTPBP3 | SNV | Missense_Mutation | c.1024N>A | p.Gly342Ser | p.G342S | Q969Y2 | protein_coding | tolerated(0.63) | benign(0.069) | TCGA-BR-A452-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
GTPBP3 | SNV | Missense_Mutation | c.1007N>T | p.Thr336Met | p.T336M | Q969Y2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D7-5577-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | calcium foliatum | PD | |
GTPBP3 | SNV | Missense_Mutation | novel | c.170C>G | p.Ala57Gly | p.A57G | Q969Y2 | protein_coding | tolerated(0.05) | benign(0.226) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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