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Gene: GTF3C3 |
Gene summary for GTF3C3 |
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Gene information | Species | Human | Gene symbol | GTF3C3 | Gene ID | 9330 |
Gene name | general transcription factor IIIC subunit 3 | |
Gene Alias | TFIIIC102 | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y5Q9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9330 | GTF3C3 | LZE4T | Human | Esophagus | ESCC | 1.09e-05 | 2.31e-01 | 0.0811 |
9330 | GTF3C3 | LZE7T | Human | Esophagus | ESCC | 2.69e-06 | 3.79e-01 | 0.0667 |
9330 | GTF3C3 | LZE8T | Human | Esophagus | ESCC | 4.22e-04 | 1.44e-01 | 0.067 |
9330 | GTF3C3 | LZE20T | Human | Esophagus | ESCC | 3.73e-02 | 1.08e-01 | 0.0662 |
9330 | GTF3C3 | LZE24T | Human | Esophagus | ESCC | 1.17e-06 | 2.18e-01 | 0.0596 |
9330 | GTF3C3 | LZE21T | Human | Esophagus | ESCC | 1.98e-02 | 1.86e-01 | 0.0655 |
9330 | GTF3C3 | P1T-E | Human | Esophagus | ESCC | 2.06e-04 | 4.43e-01 | 0.0875 |
9330 | GTF3C3 | P2T-E | Human | Esophagus | ESCC | 5.68e-14 | 2.99e-01 | 0.1177 |
9330 | GTF3C3 | P4T-E | Human | Esophagus | ESCC | 2.73e-15 | 3.64e-01 | 0.1323 |
9330 | GTF3C3 | P5T-E | Human | Esophagus | ESCC | 6.37e-06 | 1.94e-01 | 0.1327 |
9330 | GTF3C3 | P8T-E | Human | Esophagus | ESCC | 5.12e-07 | 1.81e-01 | 0.0889 |
9330 | GTF3C3 | P9T-E | Human | Esophagus | ESCC | 4.40e-07 | 1.47e-01 | 0.1131 |
9330 | GTF3C3 | P10T-E | Human | Esophagus | ESCC | 1.80e-15 | 2.83e-01 | 0.116 |
9330 | GTF3C3 | P12T-E | Human | Esophagus | ESCC | 4.16e-22 | 4.27e-01 | 0.1122 |
9330 | GTF3C3 | P15T-E | Human | Esophagus | ESCC | 2.10e-24 | 5.58e-01 | 0.1149 |
9330 | GTF3C3 | P16T-E | Human | Esophagus | ESCC | 1.81e-20 | 3.73e-01 | 0.1153 |
9330 | GTF3C3 | P17T-E | Human | Esophagus | ESCC | 3.20e-02 | 2.76e-01 | 0.1278 |
9330 | GTF3C3 | P20T-E | Human | Esophagus | ESCC | 2.95e-11 | 2.85e-01 | 0.1124 |
9330 | GTF3C3 | P21T-E | Human | Esophagus | ESCC | 1.17e-19 | 3.04e-01 | 0.1617 |
9330 | GTF3C3 | P22T-E | Human | Esophagus | ESCC | 1.68e-12 | 2.31e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063833 | Esophagus | ESCC | transcription by RNA polymerase III | 41/8552 | 46/18723 | 7.69e-10 | 1.90e-08 | 41 |
GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
GO:00093032 | Esophagus | ESCC | rRNA transcription | 28/8552 | 34/18723 | 1.21e-05 | 1.12e-04 | 28 |
GO:0009303 | Liver | HCC | rRNA transcription | 25/7958 | 34/18723 | 2.42e-04 | 1.81e-03 | 25 |
GO:0006383 | Liver | HCC | transcription by RNA polymerase III | 31/7958 | 46/18723 | 5.67e-04 | 3.61e-03 | 31 |
GO:0098781 | Liver | HCC | ncRNA transcription | 33/7958 | 56/18723 | 9.64e-03 | 3.63e-02 | 33 |
GO:00063832 | Oral cavity | OSCC | transcription by RNA polymerase III | 34/7305 | 46/18723 | 1.61e-06 | 2.11e-05 | 34 |
GO:00987811 | Oral cavity | OSCC | ncRNA transcription | 38/7305 | 56/18723 | 1.15e-05 | 1.18e-04 | 38 |
GO:00093031 | Oral cavity | OSCC | rRNA transcription | 24/7305 | 34/18723 | 1.89e-04 | 1.28e-03 | 24 |
GO:00063831 | Oral cavity | LP | transcription by RNA polymerase III | 20/4623 | 46/18723 | 4.03e-03 | 2.61e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTF3C3 | SNV | Missense_Mutation | rs371296396 | c.1922N>A | p.Arg641Gln | p.R641Q | Q9Y5Q9 | protein_coding | tolerated(0.12) | probably_damaging(0.965) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
GTF3C3 | SNV | Missense_Mutation | novel | c.589N>A | p.Gly197Ser | p.G197S | Q9Y5Q9 | protein_coding | deleterious(0.02) | possibly_damaging(0.769) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
GTF3C3 | SNV | Missense_Mutation | novel | c.877N>A | p.Ala293Thr | p.A293T | Q9Y5Q9 | protein_coding | tolerated(0.3) | possibly_damaging(0.469) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTF3C3 | SNV | Missense_Mutation | c.1709N>A | p.Arg570Gln | p.R570Q | Q9Y5Q9 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
GTF3C3 | SNV | Missense_Mutation | novel | c.2570N>A | p.Arg857Lys | p.R857K | Q9Y5Q9 | protein_coding | tolerated(0.3) | possibly_damaging(0.757) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
GTF3C3 | SNV | Missense_Mutation | c.449N>A | p.Arg150Lys | p.R150K | Q9Y5Q9 | protein_coding | deleterious(0.03) | possibly_damaging(0.787) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
GTF3C3 | SNV | Missense_Mutation | novel | c.582G>T | p.Glu194Asp | p.E194D | Q9Y5Q9 | protein_coding | deleterious(0) | possibly_damaging(0.611) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GTF3C3 | SNV | Missense_Mutation | novel | c.2626N>A | p.Ala876Thr | p.A876T | Q9Y5Q9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
GTF3C3 | SNV | Missense_Mutation | rs768934711 | c.1616N>A | p.Arg539His | p.R539H | Q9Y5Q9 | protein_coding | deleterious(0.01) | benign(0.277) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
GTF3C3 | SNV | Missense_Mutation | novel | c.1394N>A | p.Cys465Tyr | p.C465Y | Q9Y5Q9 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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