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Gene: GSTCD |
Gene summary for GSTCD |
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Gene information | Species | Human | Gene symbol | GSTCD | Gene ID | 79807 |
Gene name | glutathione S-transferase C-terminal domain containing | |
Gene Alias | GSTCD | |
Cytomap | 4q24 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8NEC7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79807 | GSTCD | CCI_1 | Human | Cervix | CC | 1.00e-04 | 5.34e-01 | 0.528 |
79807 | GSTCD | CCI_2 | Human | Cervix | CC | 9.30e-10 | 7.86e-01 | 0.5249 |
79807 | GSTCD | CCI_3 | Human | Cervix | CC | 5.28e-05 | 4.44e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSTCD | SNV | Missense_Mutation | novel | c.1667N>G | p.Glu556Gly | p.E556G | Q8NEC7 | protein_coding | deleterious(0.03) | benign(0.024) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
GSTCD | SNV | Missense_Mutation | rs147454455 | c.805G>A | p.Asp269Asn | p.D269N | Q8NEC7 | protein_coding | tolerated(0.09) | possibly_damaging(0.642) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSTCD | SNV | Missense_Mutation | rs756141476 | c.1754G>A | p.Arg585Gln | p.R585Q | Q8NEC7 | protein_coding | deleterious(0.01) | possibly_damaging(0.542) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSTCD | SNV | Missense_Mutation | novel | c.1399C>A | p.Gln467Lys | p.Q467K | Q8NEC7 | protein_coding | tolerated(0.28) | benign(0.154) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
GSTCD | SNV | Missense_Mutation | rs772646111 | c.1727N>G | p.Gln576Arg | p.Q576R | Q8NEC7 | protein_coding | deleterious(0) | benign(0.197) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GSTCD | SNV | Missense_Mutation | novel | c.16N>C | p.Lys6Gln | p.K6Q | Q8NEC7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.154) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSTCD | SNV | Missense_Mutation | novel | c.92N>T | p.Thr31Ile | p.T31I | Q8NEC7 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-EY-A1H0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
GSTCD | SNV | Missense_Mutation | novel | c.520G>A | p.Val174Ile | p.V174I | Q8NEC7 | protein_coding | tolerated(0.22) | benign(0.021) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSTCD | SNV | Missense_Mutation | novel | c.477N>T | p.Glu159Asp | p.E159D | Q8NEC7 | protein_coding | tolerated(0.13) | possibly_damaging(0.695) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
GSTCD | insertion | Frame_Shift_Ins | novel | c.817_818insCAACAACATTGGGGATCACATTTCAACATGAAATT | p.Leu273ProfsTer39 | p.L273Pfs*39 | Q8NEC7 | protein_coding | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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