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Gene: GREB1 |
Gene summary for GREB1 |
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Gene information | Species | Human | Gene symbol | GREB1 | Gene ID | 9687 |
Gene name | growth regulating estrogen receptor binding 1 | |
Gene Alias | GREB1 | |
Cytomap | 2p25.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q4ZG55 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9687 | GREB1 | AEH-subject2 | Human | Endometrium | AEH | 1.39e-02 | -1.43e-01 | -0.2525 |
9687 | GREB1 | AEH-subject3 | Human | Endometrium | AEH | 1.10e-03 | 1.87e-01 | -0.2576 |
9687 | GREB1 | AEH-subject5 | Human | Endometrium | AEH | 2.67e-25 | 6.79e-01 | -0.2953 |
9687 | GREB1 | EEC-subject1 | Human | Endometrium | EEC | 2.31e-04 | 1.70e-01 | -0.2682 |
9687 | GREB1 | EEC-subject3 | Human | Endometrium | EEC | 2.84e-03 | -9.50e-03 | -0.2525 |
9687 | GREB1 | GSM5276934 | Human | Endometrium | EEC | 1.64e-04 | -2.03e-01 | -0.0913 |
9687 | GREB1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.15e-12 | -2.44e-01 | -0.1869 |
9687 | GREB1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 8.96e-08 | -2.83e-01 | -0.1875 |
9687 | GREB1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 5.39e-11 | -2.37e-01 | -0.1883 |
9687 | GREB1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 7.35e-09 | -3.29e-03 | -0.1934 |
9687 | GREB1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.00e-13 | -2.08e-01 | -0.1917 |
9687 | GREB1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.99e-12 | -2.61e-01 | -0.1916 |
9687 | GREB1 | HCC1_Meng | Human | Liver | HCC | 2.67e-23 | 4.76e-02 | 0.0246 |
9687 | GREB1 | HCC1 | Human | Liver | HCC | 8.64e-03 | 2.13e+00 | 0.5336 |
9687 | GREB1 | HCC2 | Human | Liver | HCC | 2.18e-03 | 4.28e-01 | 0.5341 |
9687 | GREB1 | HCC5 | Human | Liver | HCC | 9.03e-06 | 1.25e+00 | 0.4932 |
9687 | GREB1 | S014 | Human | Liver | HCC | 4.16e-16 | 6.18e-01 | 0.2254 |
9687 | GREB1 | S015 | Human | Liver | HCC | 8.63e-27 | 1.06e+00 | 0.2375 |
9687 | GREB1 | S016 | Human | Liver | HCC | 3.38e-23 | 6.96e-01 | 0.2243 |
9687 | GREB1 | HTA12-23-1 | Human | Pancreas | PDAC | 4.03e-05 | 7.35e-01 | 0.3405 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer | ||
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016553 | Liver | HCC | urogenital system development | 170/7958 | 338/18723 | 2.15e-03 | 1.08e-02 | 170 |
GO:00018222 | Liver | HCC | kidney development | 148/7958 | 293/18723 | 3.25e-03 | 1.49e-02 | 148 |
GO:00720012 | Liver | HCC | renal system development | 152/7958 | 302/18723 | 3.45e-03 | 1.56e-02 | 152 |
GO:006145811 | Liver | HCC | reproductive system development | 205/7958 | 427/18723 | 1.16e-02 | 4.27e-02 | 205 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GREB1 | SNV | Missense_Mutation | rs749524420 | c.1348N>A | p.Ala450Thr | p.A450T | Q4ZG55 | protein_coding | tolerated(0.17) | benign(0.131) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GREB1 | SNV | Missense_Mutation | rs377649994 | c.5149N>A | p.Val1717Met | p.V1717M | Q4ZG55 | protein_coding | deleterious(0) | possibly_damaging(0.636) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GREB1 | SNV | Missense_Mutation | rs756448282 | c.4663G>A | p.Glu1555Lys | p.E1555K | Q4ZG55 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GREB1 | SNV | Missense_Mutation | c.4998N>A | p.Phe1666Leu | p.F1666L | Q4ZG55 | protein_coding | tolerated(0.64) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GREB1 | SNV | Missense_Mutation | novel | c.5400C>A | p.Asp1800Glu | p.D1800E | Q4ZG55 | protein_coding | deleterious(0.03) | possibly_damaging(0.894) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GREB1 | SNV | Missense_Mutation | c.304N>T | p.Arg102Cys | p.R102C | Q4ZG55 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EI-6506-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GREB1 | SNV | Missense_Mutation | c.4265C>T | p.Ala1422Val | p.A1422V | Q4ZG55 | protein_coding | tolerated(0.73) | benign(0.341) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GREB1 | SNV | Missense_Mutation | c.5461N>A | p.His1821Asn | p.H1821N | Q4ZG55 | protein_coding | tolerated(0.33) | benign(0.015) | TCGA-EI-6510-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GREB1 | SNV | Missense_Mutation | novel | c.1127A>C | p.Lys376Thr | p.K376T | Q4ZG55 | protein_coding | tolerated(0.09) | probably_damaging(0.909) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
GREB1 | SNV | Missense_Mutation | novel | c.4589G>A | p.Arg1530Gln | p.R1530Q | Q4ZG55 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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