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Gene: GRAMD1C |
Gene summary for GRAMD1C |
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Gene information | Species | Human | Gene symbol | GRAMD1C | Gene ID | 54762 |
Gene name | GRAM domain containing 1C | |
Gene Alias | GRAMD1C | |
Cytomap | 3q13.31 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8IYS0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54762 | GRAMD1C | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.17e-02 | 2.45e-01 | -0.1808 |
54762 | GRAMD1C | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.62e-14 | 7.80e-01 | -0.0811 |
54762 | GRAMD1C | HTA11_78_2000001011 | Human | Colorectum | AD | 1.95e-04 | 3.71e-01 | -0.1088 |
54762 | GRAMD1C | HTA11_347_2000001011 | Human | Colorectum | AD | 1.28e-04 | 2.44e-01 | -0.1954 |
54762 | GRAMD1C | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.77e-09 | 7.03e-01 | 0.0112 |
54762 | GRAMD1C | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.88e-11 | 7.68e-01 | 0.0588 |
54762 | GRAMD1C | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.21e-17 | 7.28e-01 | 0.294 |
54762 | GRAMD1C | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.50e-06 | 9.49e-01 | 0.3487 |
54762 | GRAMD1C | A015-C-203 | Human | Colorectum | FAP | 1.57e-04 | -1.51e-01 | -0.1294 |
54762 | GRAMD1C | A001-C-108 | Human | Colorectum | FAP | 1.41e-04 | -1.87e-01 | -0.0272 |
54762 | GRAMD1C | A015-C-104 | Human | Colorectum | FAP | 2.53e-05 | -1.23e-01 | -0.1899 |
54762 | GRAMD1C | A001-C-014 | Human | Colorectum | FAP | 8.79e-03 | -1.41e-01 | 0.0135 |
54762 | GRAMD1C | A002-C-016 | Human | Colorectum | FAP | 7.89e-05 | -1.71e-01 | 0.0521 |
54762 | GRAMD1C | A002-C-116 | Human | Colorectum | FAP | 8.85e-07 | -1.75e-01 | -0.0452 |
54762 | GRAMD1C | F034 | Human | Colorectum | FAP | 4.01e-07 | -2.11e-01 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0097305 | Colorectum | AD | response to alcohol | 71/3918 | 253/18723 | 4.01e-03 | 2.80e-02 | 71 |
GO:00973051 | Colorectum | MSS | response to alcohol | 66/3467 | 253/18723 | 1.73e-03 | 1.54e-02 | 66 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:00973052 | Colorectum | MSI-H | response to alcohol | 33/1319 | 253/18723 | 4.53e-04 | 9.61e-03 | 33 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00973053 | Colorectum | FAP | response to alcohol | 55/2622 | 253/18723 | 5.05e-04 | 5.78e-03 | 55 |
GO:0097306 | Colorectum | FAP | cellular response to alcohol | 25/2622 | 93/18723 | 7.87e-04 | 8.29e-03 | 25 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRAMD1C | SNV | Missense_Mutation | novel | c.787G>A | p.Gly263Arg | p.G263R | Q8IYS0 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRAMD1C | SNV | Missense_Mutation | novel | c.1526N>C | p.Leu509Pro | p.L509P | Q8IYS0 | protein_coding | deleterious(0) | possibly_damaging(0.58) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
GRAMD1C | SNV | Missense_Mutation | c.932N>A | p.Thr311Asn | p.T311N | Q8IYS0 | protein_coding | deleterious(0.05) | benign(0.153) | TCGA-BG-A0M6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | SD | |
GRAMD1C | SNV | Missense_Mutation | c.1000N>T | p.Ile334Phe | p.I334F | Q8IYS0 | protein_coding | deleterious(0) | benign(0.007) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GRAMD1C | SNV | Missense_Mutation | rs774536362 | c.1553G>A | p.Arg518Gln | p.R518Q | Q8IYS0 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRAMD1C | SNV | Missense_Mutation | rs201181983 | c.1883N>A | p.Arg628Gln | p.R628Q | Q8IYS0 | protein_coding | tolerated(0.61) | benign(0.003) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRAMD1C | SNV | Missense_Mutation | novel | c.1840N>A | p.Gln614Lys | p.Q614K | Q8IYS0 | protein_coding | tolerated(0.06) | benign(0.036) | TCGA-DF-A2KV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRAMD1C | SNV | Missense_Mutation | novel | c.625N>A | p.Leu209Met | p.L209M | Q8IYS0 | protein_coding | deleterious(0.04) | benign(0.044) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GRAMD1C | SNV | Missense_Mutation | rs550686355 | c.998N>A | p.Arg333His | p.R333H | Q8IYS0 | protein_coding | deleterious(0.04) | benign(0.015) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRAMD1C | SNV | Missense_Mutation | novel | c.1685N>A | p.Ser562Asn | p.S562N | Q8IYS0 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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