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Gene: GPR107 |
Gene summary for GPR107 |
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Gene information | Species | Human | Gene symbol | GPR107 | Gene ID | 57720 |
Gene name | G protein-coupled receptor 107 | |
Gene Alias | GCDRP | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5VW38 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57720 | GPR107 | CCI_1 | Human | Cervix | CC | 2.06e-02 | 4.10e-01 | 0.528 |
57720 | GPR107 | CCI_2 | Human | Cervix | CC | 4.08e-11 | 6.54e-01 | 0.5249 |
57720 | GPR107 | CCI_3 | Human | Cervix | CC | 4.93e-13 | 6.26e-01 | 0.516 |
57720 | GPR107 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.19e-11 | 5.02e-01 | -0.1954 |
57720 | GPR107 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.48e-07 | 5.99e-01 | 0.281 |
57720 | GPR107 | A015-C-203 | Human | Colorectum | FAP | 3.26e-16 | -2.88e-01 | -0.1294 |
57720 | GPR107 | A015-C-204 | Human | Colorectum | FAP | 3.53e-03 | -2.46e-01 | -0.0228 |
57720 | GPR107 | A002-C-201 | Human | Colorectum | FAP | 2.68e-04 | -1.88e-01 | 0.0324 |
57720 | GPR107 | A002-C-203 | Human | Colorectum | FAP | 5.32e-03 | -1.01e-01 | 0.2786 |
57720 | GPR107 | A001-C-119 | Human | Colorectum | FAP | 4.70e-02 | -2.86e-01 | -0.1557 |
57720 | GPR107 | A001-C-108 | Human | Colorectum | FAP | 2.19e-11 | -2.01e-01 | -0.0272 |
57720 | GPR107 | A002-C-205 | Human | Colorectum | FAP | 3.31e-10 | -1.70e-01 | -0.1236 |
57720 | GPR107 | A015-C-006 | Human | Colorectum | FAP | 5.29e-07 | -2.48e-01 | -0.0994 |
57720 | GPR107 | A015-C-106 | Human | Colorectum | FAP | 5.02e-06 | -2.02e-01 | -0.0511 |
57720 | GPR107 | A002-C-114 | Human | Colorectum | FAP | 1.19e-08 | -3.11e-01 | -0.1561 |
57720 | GPR107 | A015-C-104 | Human | Colorectum | FAP | 8.48e-20 | -3.34e-01 | -0.1899 |
57720 | GPR107 | A001-C-014 | Human | Colorectum | FAP | 4.06e-07 | -1.48e-01 | 0.0135 |
57720 | GPR107 | A002-C-016 | Human | Colorectum | FAP | 1.95e-13 | -2.21e-01 | 0.0521 |
57720 | GPR107 | A015-C-002 | Human | Colorectum | FAP | 1.61e-05 | -3.21e-01 | -0.0763 |
57720 | GPR107 | A001-C-203 | Human | Colorectum | FAP | 4.17e-05 | -9.93e-02 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068987 | Cervix | CC | receptor-mediated endocytosis | 53/2311 | 244/18723 | 2.52e-05 | 4.29e-04 | 53 |
GO:00725836 | Cervix | CC | clathrin-dependent endocytosis | 16/2311 | 47/18723 | 9.56e-05 | 1.25e-03 | 16 |
GO:0072583 | Colorectum | AD | clathrin-dependent endocytosis | 24/3918 | 47/18723 | 4.60e-06 | 1.22e-04 | 24 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:00725831 | Colorectum | MSS | clathrin-dependent endocytosis | 22/3467 | 47/18723 | 8.74e-06 | 2.16e-04 | 22 |
GO:00068981 | Colorectum | MSS | receptor-mediated endocytosis | 69/3467 | 244/18723 | 1.18e-04 | 1.82e-03 | 69 |
GO:00725832 | Colorectum | FAP | clathrin-dependent endocytosis | 21/2622 | 47/18723 | 3.45e-07 | 1.87e-05 | 21 |
GO:00068982 | Colorectum | FAP | receptor-mediated endocytosis | 62/2622 | 244/18723 | 1.47e-06 | 6.39e-05 | 62 |
GO:00725833 | Colorectum | CRC | clathrin-dependent endocytosis | 18/2078 | 47/18723 | 1.16e-06 | 6.75e-05 | 18 |
GO:00068983 | Colorectum | CRC | receptor-mediated endocytosis | 50/2078 | 244/18723 | 1.27e-05 | 4.08e-04 | 50 |
GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
GO:007258314 | Esophagus | ESCC | clathrin-dependent endocytosis | 34/8552 | 47/18723 | 1.91e-04 | 1.21e-03 | 34 |
GO:000689821 | Liver | HCC | receptor-mediated endocytosis | 134/7958 | 244/18723 | 5.73e-05 | 5.31e-04 | 134 |
GO:007258311 | Liver | HCC | clathrin-dependent endocytosis | 31/7958 | 47/18723 | 9.90e-04 | 5.71e-03 | 31 |
GO:000689810 | Oral cavity | OSCC | receptor-mediated endocytosis | 125/7305 | 244/18723 | 6.56e-05 | 5.32e-04 | 125 |
GO:00725838 | Oral cavity | OSCC | clathrin-dependent endocytosis | 30/7305 | 47/18723 | 4.96e-04 | 2.92e-03 | 30 |
GO:007258321 | Oral cavity | EOLP | clathrin-dependent endocytosis | 19/2218 | 47/18723 | 6.00e-07 | 1.56e-05 | 19 |
GO:000689825 | Oral cavity | EOLP | receptor-mediated endocytosis | 55/2218 | 244/18723 | 1.64e-06 | 3.82e-05 | 55 |
GO:0006898110 | Thyroid | PTC | receptor-mediated endocytosis | 112/5968 | 244/18723 | 2.87e-06 | 3.74e-05 | 112 |
GO:007258310 | Thyroid | PTC | clathrin-dependent endocytosis | 30/5968 | 47/18723 | 6.62e-06 | 7.83e-05 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR107 | SNV | Missense_Mutation | rs779627192 | c.860G>A | p.Arg287Gln | p.R287Q | Q5VW38 | protein_coding | tolerated(0.08) | possibly_damaging(0.732) | TCGA-CX-7085-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GPR107 | SNV | Missense_Mutation | rs199776309 | c.1552N>A | p.Ala518Thr | p.A518T | Q5VW38 | protein_coding | tolerated(0.79) | possibly_damaging(0.892) | TCGA-T2-A6X0-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
GPR107 | SNV | Missense_Mutation | rs200754726 | c.854N>A | p.Arg285Gln | p.R285Q | Q5VW38 | protein_coding | tolerated(0.34) | possibly_damaging(0.732) | TCGA-QU-A6IM-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
GPR107 | SNV | Missense_Mutation | rs201905145 | c.1639C>T | p.Arg547Cys | p.R547C | Q5VW38 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
GPR107 | SNV | Missense_Mutation | c.1144N>A | p.Val382Ile | p.V382I | Q5VW38 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPR107 | SNV | Missense_Mutation | c.1025N>T | p.Ala342Val | p.A342V | Q5VW38 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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