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Gene: GOPC |
Gene summary for GOPC |
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Gene information | Species | Human | Gene symbol | GOPC | Gene ID | 57120 |
Gene name | golgi associated PDZ and coiled-coil motif containing | |
Gene Alias | CAL | |
Cytomap | 6q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9HD26 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57120 | GOPC | LZE2T | Human | Esophagus | ESCC | 2.43e-03 | 5.90e-01 | 0.082 |
57120 | GOPC | LZE4T | Human | Esophagus | ESCC | 4.23e-19 | 5.10e-01 | 0.0811 |
57120 | GOPC | LZE7T | Human | Esophagus | ESCC | 1.39e-05 | 3.86e-01 | 0.0667 |
57120 | GOPC | LZE8T | Human | Esophagus | ESCC | 1.38e-10 | 3.93e-01 | 0.067 |
57120 | GOPC | LZE20T | Human | Esophagus | ESCC | 4.17e-07 | 2.66e-01 | 0.0662 |
57120 | GOPC | LZE22T | Human | Esophagus | ESCC | 2.61e-04 | 5.25e-01 | 0.068 |
57120 | GOPC | LZE24T | Human | Esophagus | ESCC | 9.96e-19 | 6.18e-01 | 0.0596 |
57120 | GOPC | LZE21T | Human | Esophagus | ESCC | 1.18e-06 | 3.03e-01 | 0.0655 |
57120 | GOPC | LZE6T | Human | Esophagus | ESCC | 5.38e-04 | 5.10e-01 | 0.0845 |
57120 | GOPC | P1T-E | Human | Esophagus | ESCC | 6.08e-10 | 7.33e-01 | 0.0875 |
57120 | GOPC | P2T-E | Human | Esophagus | ESCC | 4.17e-57 | 8.73e-01 | 0.1177 |
57120 | GOPC | P4T-E | Human | Esophagus | ESCC | 1.11e-43 | 1.03e+00 | 0.1323 |
57120 | GOPC | P5T-E | Human | Esophagus | ESCC | 1.78e-39 | 7.26e-01 | 0.1327 |
57120 | GOPC | P8T-E | Human | Esophagus | ESCC | 1.93e-36 | 7.99e-01 | 0.0889 |
57120 | GOPC | P9T-E | Human | Esophagus | ESCC | 2.89e-13 | 3.85e-01 | 0.1131 |
57120 | GOPC | P10T-E | Human | Esophagus | ESCC | 4.18e-48 | 8.53e-01 | 0.116 |
57120 | GOPC | P11T-E | Human | Esophagus | ESCC | 2.06e-19 | 7.60e-01 | 0.1426 |
57120 | GOPC | P12T-E | Human | Esophagus | ESCC | 2.38e-58 | 9.48e-01 | 0.1122 |
57120 | GOPC | P15T-E | Human | Esophagus | ESCC | 7.90e-36 | 8.69e-01 | 0.1149 |
57120 | GOPC | P16T-E | Human | Esophagus | ESCC | 2.67e-51 | 1.07e+00 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:000689215 | Esophagus | ESCC | post-Golgi vesicle-mediated transport | 82/8552 | 104/18723 | 4.00e-12 | 1.55e-10 | 82 |
GO:009887615 | Esophagus | ESCC | vesicle-mediated transport to the plasma membrane | 99/8552 | 136/18723 | 1.13e-10 | 3.39e-09 | 99 |
GO:0045185111 | Esophagus | ESCC | maintenance of protein location | 71/8552 | 94/18723 | 3.41e-09 | 7.24e-08 | 71 |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:190547519 | Esophagus | ESCC | regulation of protein localization to membrane | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:000689315 | Esophagus | ESCC | Golgi to plasma membrane transport | 48/8552 | 60/18723 | 5.11e-08 | 9.16e-07 | 48 |
GO:004300114 | Esophagus | ESCC | Golgi to plasma membrane protein transport | 34/8552 | 40/18723 | 3.00e-07 | 4.27e-06 | 34 |
GO:190437519 | Esophagus | ESCC | regulation of protein localization to cell periphery | 85/8552 | 125/18723 | 3.63e-07 | 5.06e-06 | 85 |
GO:1903076110 | Esophagus | ESCC | regulation of protein localization to plasma membrane | 72/8552 | 104/18723 | 9.74e-07 | 1.23e-05 | 72 |
GO:006195114 | Esophagus | ESCC | establishment of protein localization to plasma membrane | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:19038289 | Esophagus | ESCC | negative regulation of cellular protein localization | 76/8552 | 117/18723 | 1.97e-05 | 1.72e-04 | 76 |
GO:005122013 | Esophagus | ESCC | cytoplasmic sequestering of protein | 18/8552 | 22/18723 | 5.69e-04 | 3.10e-03 | 18 |
GO:00512244 | Esophagus | ESCC | negative regulation of protein transport | 74/8552 | 127/18723 | 2.86e-03 | 1.21e-02 | 74 |
GO:19049505 | Esophagus | ESCC | negative regulation of establishment of protein localization | 76/8552 | 131/18723 | 2.96e-03 | 1.24e-02 | 76 |
GO:19030778 | Esophagus | ESCC | negative regulation of protein localization to plasma membrane | 17/8552 | 24/18723 | 1.13e-02 | 3.81e-02 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GOPC | SNV | Missense_Mutation | c.961G>T | p.Gly321Trp | p.G321W | Q9HD26 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GOPC | SNV | Missense_Mutation | c.1117G>A | p.Glu373Lys | p.E373K | Q9HD26 | protein_coding | deleterious(0.01) | possibly_damaging(0.784) | TCGA-NJ-A4YI-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GOPC | SNV | Missense_Mutation | novel | c.44C>T | p.Pro15Leu | p.P15L | Q9HD26 | protein_coding | deleterious_low_confidence(0) | benign(0.036) | TCGA-52-7811-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GOPC | SNV | Missense_Mutation | novel | c.742N>T | p.Arg248Cys | p.R248C | Q9HD26 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-58-A46N-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
GOPC | SNV | Missense_Mutation | novel | c.361N>A | p.Asp121Asn | p.D121N | Q9HD26 | protein_coding | tolerated(0.68) | benign(0) | TCGA-63-A5MT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
GOPC | SNV | Missense_Mutation | novel | c.983N>A | p.Gly328Glu | p.G328E | Q9HD26 | protein_coding | tolerated(0.11) | possibly_damaging(0.46) | TCGA-BB-A5HU-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
GOPC | SNV | Missense_Mutation | rs751358313 | c.982N>A | p.Gly328Arg | p.G328R | Q9HD26 | protein_coding | tolerated(0.07) | benign(0.33) | TCGA-CV-5970-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
GOPC | SNV | Missense_Mutation | novel | c.355N>A | p.Val119Ile | p.V119I | Q9HD26 | protein_coding | tolerated(0.08) | benign(0.297) | TCGA-UF-A71B-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GOPC | SNV | Missense_Mutation | c.811N>T | p.Gly271Cys | p.G271C | Q9HD26 | protein_coding | deleterious(0.01) | possibly_damaging(0.72) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GOPC | SNV | Missense_Mutation | rs373622148 | c.1337G>A | p.Gly446Asp | p.G446D | Q9HD26 | protein_coding | tolerated_low_confidence(0.11) | benign(0) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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