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Gene: GOLPH3 |
Gene summary for GOLPH3 |
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Gene information | Species | Human | Gene symbol | GOLPH3 | Gene ID | 64083 |
Gene name | golgi phosphoprotein 3 | |
Gene Alias | GOPP1 | |
Cytomap | 5p13.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9H4A6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64083 | GOLPH3 | CCI_1 | Human | Cervix | CC | 4.95e-04 | 6.57e-01 | 0.528 |
64083 | GOLPH3 | CCI_3 | Human | Cervix | CC | 1.07e-06 | 6.50e-01 | 0.516 |
64083 | GOLPH3 | sample3 | Human | Cervix | CC | 1.15e-07 | 2.51e-01 | 0.1387 |
64083 | GOLPH3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.71e-14 | -5.18e-01 | 0.0155 |
64083 | GOLPH3 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.81e-03 | -2.31e-01 | -0.1464 |
64083 | GOLPH3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.72e-07 | -3.28e-01 | 0.0674 |
64083 | GOLPH3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.28e-13 | -4.22e-01 | 0.3005 |
64083 | GOLPH3 | F007 | Human | Colorectum | FAP | 4.72e-03 | -3.21e-01 | 0.1176 |
64083 | GOLPH3 | A002-C-010 | Human | Colorectum | FAP | 1.15e-03 | -1.55e-01 | 0.242 |
64083 | GOLPH3 | A015-C-203 | Human | Colorectum | FAP | 9.00e-29 | -3.47e-01 | -0.1294 |
64083 | GOLPH3 | A015-C-204 | Human | Colorectum | FAP | 3.74e-05 | -2.24e-01 | -0.0228 |
64083 | GOLPH3 | A014-C-040 | Human | Colorectum | FAP | 1.10e-05 | -4.38e-01 | -0.1184 |
64083 | GOLPH3 | A002-C-201 | Human | Colorectum | FAP | 1.52e-13 | -2.97e-01 | 0.0324 |
64083 | GOLPH3 | A002-C-203 | Human | Colorectum | FAP | 1.93e-07 | -1.98e-01 | 0.2786 |
64083 | GOLPH3 | A001-C-119 | Human | Colorectum | FAP | 3.06e-08 | -2.82e-01 | -0.1557 |
64083 | GOLPH3 | A001-C-108 | Human | Colorectum | FAP | 7.58e-18 | -3.17e-01 | -0.0272 |
64083 | GOLPH3 | A002-C-205 | Human | Colorectum | FAP | 1.25e-19 | -2.78e-01 | -0.1236 |
64083 | GOLPH3 | A014-C-108 | Human | Colorectum | FAP | 1.38e-02 | -3.39e-01 | -0.124 |
64083 | GOLPH3 | A001-C-104 | Human | Colorectum | FAP | 1.06e-08 | -2.88e-01 | 0.0184 |
64083 | GOLPH3 | A015-C-006 | Human | Colorectum | FAP | 1.90e-14 | -4.55e-01 | -0.0994 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:00300108 | Cervix | CC | establishment of cell polarity | 42/2311 | 143/18723 | 4.30e-08 | 2.62e-06 | 42 |
GO:00975817 | Cervix | CC | lamellipodium organization | 31/2311 | 90/18723 | 4.57e-08 | 2.76e-06 | 31 |
GO:005165110 | Cervix | CC | maintenance of location in cell | 55/2311 | 214/18723 | 6.63e-08 | 3.85e-06 | 55 |
GO:190495110 | Cervix | CC | positive regulation of establishment of protein localization | 73/2311 | 319/18723 | 9.69e-08 | 5.25e-06 | 73 |
GO:00300325 | Cervix | CC | lamellipodium assembly | 26/2311 | 72/18723 | 1.87e-07 | 8.48e-06 | 26 |
GO:00509007 | Cervix | CC | leukocyte migration | 78/2311 | 369/18723 | 1.09e-06 | 3.80e-05 | 78 |
GO:190165410 | Cervix | CC | response to ketone | 45/2311 | 194/18723 | 1.83e-05 | 3.44e-04 | 45 |
GO:00325077 | Cervix | CC | maintenance of protein location in cell | 21/2311 | 65/18723 | 2.03e-05 | 3.71e-04 | 21 |
GO:000690010 | Cervix | CC | vesicle budding from membrane | 20/2311 | 61/18723 | 2.50e-05 | 4.28e-04 | 20 |
GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
GO:00068927 | Cervix | CC | post-Golgi vesicle-mediated transport | 28/2311 | 104/18723 | 4.31e-05 | 6.61e-04 | 28 |
GO:004518510 | Cervix | CC | maintenance of protein location | 26/2311 | 94/18723 | 4.85e-05 | 7.34e-04 | 26 |
GO:00901509 | Cervix | CC | establishment of protein localization to membrane | 54/2311 | 260/18723 | 7.67e-05 | 1.05e-03 | 54 |
GO:00108218 | Cervix | CC | regulation of mitochondrion organization | 34/2311 | 144/18723 | 1.27e-04 | 1.58e-03 | 34 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GOLPH3 | insertion | In_Frame_Ins | novel | c.578_579insGAA | p.Gln192_Asn193insLys | p.Q192_N193insK | Q9H4A6 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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