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Gene: GLMP |
Gene summary for GLMP |
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Gene information | Species | Human | Gene symbol | GLMP | Gene ID | 112770 |
Gene name | glycosylated lysosomal membrane protein | |
Gene Alias | C1orf85 | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A087WV34 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
112770 | GLMP | LZE4T | Human | Esophagus | ESCC | 5.95e-08 | 1.20e-01 | 0.0811 |
112770 | GLMP | LZE7T | Human | Esophagus | ESCC | 2.22e-10 | 4.70e-01 | 0.0667 |
112770 | GLMP | LZE8T | Human | Esophagus | ESCC | 3.77e-05 | 4.51e-02 | 0.067 |
112770 | GLMP | LZE20T | Human | Esophagus | ESCC | 1.42e-03 | 1.18e-01 | 0.0662 |
112770 | GLMP | LZE22D1 | Human | Esophagus | HGIN | 1.86e-02 | 5.98e-02 | 0.0595 |
112770 | GLMP | LZE22T | Human | Esophagus | ESCC | 9.13e-08 | 3.68e-01 | 0.068 |
112770 | GLMP | LZE24T | Human | Esophagus | ESCC | 2.02e-24 | 5.77e-01 | 0.0596 |
112770 | GLMP | LZE6T | Human | Esophagus | ESCC | 1.73e-06 | 3.02e-01 | 0.0845 |
112770 | GLMP | P1T-E | Human | Esophagus | ESCC | 3.90e-10 | 6.92e-01 | 0.0875 |
112770 | GLMP | P2T-E | Human | Esophagus | ESCC | 9.74e-27 | 6.44e-01 | 0.1177 |
112770 | GLMP | P4T-E | Human | Esophagus | ESCC | 3.51e-33 | 6.85e-01 | 0.1323 |
112770 | GLMP | P5T-E | Human | Esophagus | ESCC | 6.82e-19 | 4.78e-01 | 0.1327 |
112770 | GLMP | P8T-E | Human | Esophagus | ESCC | 3.75e-18 | 4.51e-01 | 0.0889 |
112770 | GLMP | P9T-E | Human | Esophagus | ESCC | 5.97e-32 | 7.03e-01 | 0.1131 |
112770 | GLMP | P10T-E | Human | Esophagus | ESCC | 2.16e-13 | 3.12e-01 | 0.116 |
112770 | GLMP | P11T-E | Human | Esophagus | ESCC | 1.16e-26 | 9.45e-01 | 0.1426 |
112770 | GLMP | P12T-E | Human | Esophagus | ESCC | 5.97e-15 | 2.80e-01 | 0.1122 |
112770 | GLMP | P15T-E | Human | Esophagus | ESCC | 1.11e-38 | 8.29e-01 | 0.1149 |
112770 | GLMP | P16T-E | Human | Esophagus | ESCC | 7.97e-29 | 4.45e-01 | 0.1153 |
112770 | GLMP | P17T-E | Human | Esophagus | ESCC | 6.21e-21 | 6.15e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003164727 | Esophagus | HGIN | regulation of protein stability | 96/2587 | 298/18723 | 2.21e-16 | 5.76e-14 | 96 |
GO:005082127 | Esophagus | HGIN | protein stabilization | 64/2587 | 191/18723 | 3.11e-12 | 4.24e-10 | 64 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:0050821111 | Esophagus | ESCC | protein stabilization | 140/8552 | 191/18723 | 6.50e-15 | 3.61e-13 | 140 |
GO:00726659 | Esophagus | ESCC | protein localization to vacuole | 52/8552 | 67/18723 | 9.14e-08 | 1.52e-06 | 52 |
GO:00614626 | Esophagus | ESCC | protein localization to lysosome | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
GO:003164712 | Liver | Cirrhotic | regulation of protein stability | 144/4634 | 298/18723 | 6.74e-19 | 1.28e-16 | 144 |
GO:005082112 | Liver | Cirrhotic | protein stabilization | 97/4634 | 191/18723 | 6.67e-15 | 6.97e-13 | 97 |
GO:007266511 | Liver | Cirrhotic | protein localization to vacuole | 37/4634 | 67/18723 | 9.11e-08 | 2.66e-06 | 37 |
GO:00614622 | Liver | Cirrhotic | protein localization to lysosome | 24/4634 | 46/18723 | 5.75e-05 | 6.58e-04 | 24 |
GO:003164722 | Liver | HCC | regulation of protein stability | 211/7958 | 298/18723 | 2.29e-23 | 5.01e-21 | 211 |
GO:005082122 | Liver | HCC | protein stabilization | 139/7958 | 191/18723 | 1.61e-17 | 1.71e-15 | 139 |
GO:007266521 | Liver | HCC | protein localization to vacuole | 48/7958 | 67/18723 | 1.27e-06 | 1.85e-05 | 48 |
GO:00614621 | Liver | HCC | protein localization to lysosome | 33/7958 | 46/18723 | 5.63e-05 | 5.26e-04 | 33 |
GO:003164720 | Oral cavity | OSCC | regulation of protein stability | 193/7305 | 298/18723 | 1.30e-19 | 1.95e-17 | 193 |
GO:005082120 | Oral cavity | OSCC | protein stabilization | 122/7305 | 191/18723 | 2.69e-12 | 1.09e-10 | 122 |
GO:00726658 | Oral cavity | OSCC | protein localization to vacuole | 44/7305 | 67/18723 | 8.92e-06 | 9.44e-05 | 44 |
GO:00614625 | Oral cavity | OSCC | protein localization to lysosome | 28/7305 | 46/18723 | 2.19e-03 | 9.95e-03 | 28 |
GO:0031647110 | Oral cavity | LP | regulation of protein stability | 132/4623 | 298/18723 | 8.16e-14 | 7.99e-12 | 132 |
GO:0050821110 | Oral cavity | LP | protein stabilization | 88/4623 | 191/18723 | 9.15e-11 | 5.51e-09 | 88 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLMP | SNV | Missense_Mutation | novel | c.898T>C | p.Cys300Arg | p.C300R | Q8WWB7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-UF-A71A-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GLMP | SNV | Missense_Mutation | rs199574266 | c.881N>A | p.Arg294Gln | p.R294Q | Q8WWB7 | protein_coding | tolerated(0.06) | possibly_damaging(0.786) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
GLMP | SNV | Missense_Mutation | c.547N>G | p.Arg183Gly | p.R183G | Q8WWB7 | protein_coding | tolerated(1) | benign(0) | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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