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Gene: GFOD2 |
Gene summary for GFOD2 |
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Gene information | Species | Human | Gene symbol | GFOD2 | Gene ID | 81577 |
Gene name | glucose-fructose oxidoreductase domain containing 2 | |
Gene Alias | GFOD2 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q3B7J2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81577 | GFOD2 | LZE4T | Human | Esophagus | ESCC | 4.31e-05 | 1.69e-01 | 0.0811 |
81577 | GFOD2 | LZE8T | Human | Esophagus | ESCC | 2.94e-02 | 1.33e-01 | 0.067 |
81577 | GFOD2 | LZE24T | Human | Esophagus | ESCC | 4.55e-08 | 2.71e-01 | 0.0596 |
81577 | GFOD2 | P1T-E | Human | Esophagus | ESCC | 1.69e-08 | 3.98e-01 | 0.0875 |
81577 | GFOD2 | P2T-E | Human | Esophagus | ESCC | 7.95e-16 | 2.60e-01 | 0.1177 |
81577 | GFOD2 | P4T-E | Human | Esophagus | ESCC | 1.52e-11 | 2.76e-01 | 0.1323 |
81577 | GFOD2 | P5T-E | Human | Esophagus | ESCC | 8.63e-13 | 1.48e-01 | 0.1327 |
81577 | GFOD2 | P8T-E | Human | Esophagus | ESCC | 2.92e-14 | 2.33e-01 | 0.0889 |
81577 | GFOD2 | P10T-E | Human | Esophagus | ESCC | 7.27e-14 | 1.27e-01 | 0.116 |
81577 | GFOD2 | P11T-E | Human | Esophagus | ESCC | 7.43e-08 | 2.88e-01 | 0.1426 |
81577 | GFOD2 | P12T-E | Human | Esophagus | ESCC | 2.76e-07 | 1.60e-01 | 0.1122 |
81577 | GFOD2 | P15T-E | Human | Esophagus | ESCC | 4.31e-16 | 3.32e-01 | 0.1149 |
81577 | GFOD2 | P16T-E | Human | Esophagus | ESCC | 2.92e-08 | 1.52e-01 | 0.1153 |
81577 | GFOD2 | P20T-E | Human | Esophagus | ESCC | 2.34e-06 | 1.63e-01 | 0.1124 |
81577 | GFOD2 | P21T-E | Human | Esophagus | ESCC | 7.59e-18 | 3.73e-01 | 0.1617 |
81577 | GFOD2 | P22T-E | Human | Esophagus | ESCC | 1.03e-19 | 2.87e-01 | 0.1236 |
81577 | GFOD2 | P23T-E | Human | Esophagus | ESCC | 5.24e-23 | 4.92e-01 | 0.108 |
81577 | GFOD2 | P24T-E | Human | Esophagus | ESCC | 1.68e-11 | 2.36e-01 | 0.1287 |
81577 | GFOD2 | P26T-E | Human | Esophagus | ESCC | 3.38e-19 | 3.15e-01 | 0.1276 |
81577 | GFOD2 | P27T-E | Human | Esophagus | ESCC | 4.26e-16 | 2.06e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:00301983 | Oral cavity | OSCC | extracellular matrix organization | 146/7305 | 301/18723 | 4.67e-04 | 2.77e-03 | 146 |
GO:00452293 | Oral cavity | OSCC | external encapsulating structure organization | 147/7305 | 304/18723 | 5.30e-04 | 3.08e-03 | 147 |
GO:00430623 | Oral cavity | OSCC | extracellular structure organization | 146/7305 | 302/18723 | 5.59e-04 | 3.23e-03 | 146 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GFOD2 | SNV | Missense_Mutation | c.595N>A | p.Gly199Arg | p.G199R | Q3B7J2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
GFOD2 | SNV | Missense_Mutation | rs552557039 | c.943N>T | p.Arg315Cys | p.R315C | Q3B7J2 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-BR-7703-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GFOD2 | SNV | Missense_Mutation | novel | c.1036A>G | p.Ser346Gly | p.S346G | Q3B7J2 | protein_coding | deleterious(0.02) | benign(0.065) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
GFOD2 | SNV | Missense_Mutation | c.638G>A | p.Gly213Asp | p.G213D | Q3B7J2 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GFOD2 | SNV | Missense_Mutation | rs778494433 | c.775C>T | p.Arg259Cys | p.R259C | Q3B7J2 | protein_coding | tolerated(0.07) | benign(0.099) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
GFOD2 | deletion | Frame_Shift_Del | novel | c.224delN | p.Pro75LeufsTer9 | p.P75Lfs*9 | Q3B7J2 | protein_coding | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GFOD2 | SNV | Missense_Mutation | novel | c.535N>T | p.Gly179Trp | p.G179W | Q3B7J2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DJ-A2PX-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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