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Gene: FUT3 |
Gene summary for FUT3 |
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Gene information | Species | Human | Gene symbol | FUT3 | Gene ID | 2525 |
Gene name | fucosyltransferase 3 (Lewis blood group) | |
Gene Alias | CD174 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A8K737 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2525 | FUT3 | LZE5T | Human | Esophagus | ESCC | 7.03e-04 | 3.78e-01 | 0.0514 |
2525 | FUT3 | LZE24T | Human | Esophagus | ESCC | 1.12e-07 | 4.22e-01 | 0.0596 |
2525 | FUT3 | P1T-E | Human | Esophagus | ESCC | 1.43e-07 | 1.46e+00 | 0.0875 |
2525 | FUT3 | P8T-E | Human | Esophagus | ESCC | 5.64e-21 | 4.42e-01 | 0.0889 |
2525 | FUT3 | P23T-E | Human | Esophagus | ESCC | 1.30e-17 | 1.53e+00 | 0.108 |
2525 | FUT3 | P39T-E | Human | Esophagus | ESCC | 1.28e-20 | 9.74e-01 | 0.0894 |
2525 | FUT3 | P57T-E | Human | Esophagus | ESCC | 5.02e-08 | 2.65e-01 | 0.0926 |
2525 | FUT3 | P61T-E | Human | Esophagus | ESCC | 3.13e-05 | 6.46e-02 | 0.099 |
2525 | FUT3 | P74T-E | Human | Esophagus | ESCC | 2.15e-06 | 3.64e-01 | 0.1479 |
2525 | FUT3 | P75T-E | Human | Esophagus | ESCC | 4.97e-23 | 9.48e-01 | 0.1125 |
2525 | FUT3 | P82T-E | Human | Esophagus | ESCC | 1.08e-11 | 1.14e+00 | 0.1072 |
2525 | FUT3 | P94T-E | Human | Esophagus | ESCC | 2.07e-04 | 9.37e-01 | 0.0879 |
2525 | FUT3 | P126T-E | Human | Esophagus | ESCC | 3.26e-02 | 9.56e-01 | 0.1125 |
2525 | FUT3 | P127T-E | Human | Esophagus | ESCC | 6.28e-10 | 3.73e-01 | 0.0826 |
2525 | FUT3 | P128T-E | Human | Esophagus | ESCC | 1.53e-22 | 1.02e+00 | 0.1241 |
2525 | FUT3 | C21 | Human | Oral cavity | OSCC | 4.68e-06 | 6.14e-01 | 0.2678 |
2525 | FUT3 | C57 | Human | Oral cavity | OSCC | 2.98e-48 | 1.66e+00 | 0.1679 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004578527 | Esophagus | ESCC | positive regulation of cell adhesion | 255/8552 | 437/18723 | 5.07e-08 | 9.11e-07 | 255 |
GO:00066433 | Esophagus | ESCC | membrane lipid metabolic process | 130/8552 | 203/18723 | 9.29e-08 | 1.54e-06 | 130 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00066652 | Esophagus | ESCC | sphingolipid metabolic process | 96/8552 | 155/18723 | 3.21e-05 | 2.66e-04 | 96 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
GO:002240919 | Esophagus | ESCC | positive regulation of cell-cell adhesion | 155/8552 | 284/18723 | 1.50e-03 | 7.06e-03 | 155 |
GO:00066721 | Esophagus | ESCC | ceramide metabolic process | 61/8552 | 102/18723 | 2.82e-03 | 1.19e-02 | 61 |
GO:004578520 | Oral cavity | OSCC | positive regulation of cell adhesion | 225/7305 | 437/18723 | 6.06e-08 | 1.09e-06 | 225 |
GO:00066432 | Oral cavity | OSCC | membrane lipid metabolic process | 111/7305 | 203/18723 | 4.02e-06 | 4.69e-05 | 111 |
GO:002240718 | Oral cavity | OSCC | regulation of cell-cell adhesion | 218/7305 | 448/18723 | 1.71e-05 | 1.68e-04 | 218 |
GO:00066651 | Oral cavity | OSCC | sphingolipid metabolic process | 84/7305 | 155/18723 | 8.64e-05 | 6.61e-04 | 84 |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
GO:00091011 | Oral cavity | OSCC | glycoprotein biosynthetic process | 151/7305 | 317/18723 | 1.01e-03 | 5.26e-03 | 151 |
GO:00064864 | Oral cavity | OSCC | protein glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:00434134 | Oral cavity | OSCC | macromolecule glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FUT3 | SNV | Missense_Mutation | novel | c.922N>C | p.Glu308Gln | p.E308Q | P21217 | protein_coding | tolerated(0.37) | benign(0.013) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
FUT3 | SNV | Missense_Mutation | c.115N>A | p.Asp39Asn | p.D39N | P21217 | protein_coding | tolerated(0.3) | benign(0.159) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FUT3 | SNV | Missense_Mutation | c.683N>G | p.Pro228Arg | p.P228R | P21217 | protein_coding | deleterious(0.03) | benign(0.029) | TCGA-MP-A4TF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | navelbine | PD | |
FUT3 | SNV | Missense_Mutation | c.223N>T | p.Pro75Ser | p.P75S | P21217 | protein_coding | tolerated(0.59) | possibly_damaging(0.878) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
FUT3 | SNV | Missense_Mutation | c.778N>A | p.Leu260Met | p.L260M | P21217 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-43-6647-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | CR | |
FUT3 | SNV | Missense_Mutation | novel | c.457T>C | p.Phe153Leu | p.F153L | P21217 | protein_coding | deleterious(0.04) | possibly_damaging(0.654) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
FUT3 | SNV | Missense_Mutation | c.391N>G | p.Arg131Gly | p.R131G | P21217 | protein_coding | deleterious(0.01) | probably_damaging(0.948) | TCGA-66-2783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
FUT3 | insertion | Frame_Shift_Ins | novel | c.910_911insC | p.Arg304ProfsTer191 | p.R304Pfs*191 | P21217 | protein_coding | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
FUT3 | SNV | Missense_Mutation | rs141188376 | c.344N>A | p.Ser115Tyr | p.S115Y | P21217 | protein_coding | tolerated(1) | benign(0) | TCGA-MT-A67D-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FUT3 | SNV | Missense_Mutation | c.16G>A | p.Ala6Thr | p.A6T | P21217 | protein_coding | tolerated(0.59) | benign(0) | TCGA-BR-8483-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2525 | FUT3 | ENZYME | Rebmab-100 |
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