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Gene: FOXP4 |
Gene summary for FOXP4 |
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Gene information | Species | Human | Gene symbol | FOXP4 | Gene ID | 116113 |
Gene name | forkhead box P4 | |
Gene Alias | hFKHLA | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8IVH2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116113 | FOXP4 | LZE2T | Human | Esophagus | ESCC | 8.58e-05 | 4.89e-01 | 0.082 |
116113 | FOXP4 | LZE24T | Human | Esophagus | ESCC | 6.20e-04 | 4.05e-02 | 0.0596 |
116113 | FOXP4 | P2T-E | Human | Esophagus | ESCC | 8.15e-18 | 2.94e-01 | 0.1177 |
116113 | FOXP4 | P4T-E | Human | Esophagus | ESCC | 6.19e-17 | 1.81e-01 | 0.1323 |
116113 | FOXP4 | P8T-E | Human | Esophagus | ESCC | 3.38e-13 | 2.63e-01 | 0.0889 |
116113 | FOXP4 | P9T-E | Human | Esophagus | ESCC | 8.51e-06 | 5.55e-02 | 0.1131 |
116113 | FOXP4 | P10T-E | Human | Esophagus | ESCC | 1.62e-03 | 4.59e-03 | 0.116 |
116113 | FOXP4 | P11T-E | Human | Esophagus | ESCC | 3.14e-03 | 7.37e-02 | 0.1426 |
116113 | FOXP4 | P12T-E | Human | Esophagus | ESCC | 2.49e-08 | 1.49e-02 | 0.1122 |
116113 | FOXP4 | P16T-E | Human | Esophagus | ESCC | 3.43e-09 | 1.03e-01 | 0.1153 |
116113 | FOXP4 | P17T-E | Human | Esophagus | ESCC | 2.23e-03 | 1.49e-01 | 0.1278 |
116113 | FOXP4 | P21T-E | Human | Esophagus | ESCC | 8.94e-08 | 6.31e-02 | 0.1617 |
116113 | FOXP4 | P22T-E | Human | Esophagus | ESCC | 3.02e-13 | 7.15e-02 | 0.1236 |
116113 | FOXP4 | P23T-E | Human | Esophagus | ESCC | 5.95e-10 | 1.62e-01 | 0.108 |
116113 | FOXP4 | P24T-E | Human | Esophagus | ESCC | 1.07e-02 | 2.25e-02 | 0.1287 |
116113 | FOXP4 | P26T-E | Human | Esophagus | ESCC | 1.86e-02 | -4.23e-03 | 0.1276 |
116113 | FOXP4 | P27T-E | Human | Esophagus | ESCC | 1.99e-09 | 7.62e-02 | 0.1055 |
116113 | FOXP4 | P28T-E | Human | Esophagus | ESCC | 1.46e-06 | 7.45e-02 | 0.1149 |
116113 | FOXP4 | P30T-E | Human | Esophagus | ESCC | 5.97e-05 | 8.81e-02 | 0.137 |
116113 | FOXP4 | P31T-E | Human | Esophagus | ESCC | 6.00e-07 | 7.98e-02 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXP4 | SNV | Missense_Mutation | rs774217831 | c.281N>T | p.Gln94Leu | p.Q94L | Q8IVH2 | protein_coding | tolerated(0.07) | probably_damaging(0.932) | TCGA-33-6737-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | PD |
FOXP4 | SNV | Missense_Mutation | novel | c.1355N>T | p.Ser452Leu | p.S452L | Q8IVH2 | protein_coding | deleterious(0.01) | benign(0.067) | TCGA-52-7809-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FOXP4 | SNV | Missense_Mutation | novel | c.1111C>A | p.His371Asn | p.H371N | Q8IVH2 | protein_coding | deleterious(0.02) | benign(0.027) | TCGA-58-A46L-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
FOXP4 | SNV | Missense_Mutation | rs781448348 | c.794N>T | p.Pro265Leu | p.P265L | Q8IVH2 | protein_coding | deleterious(0.03) | benign(0.101) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FOXP4 | SNV | Missense_Mutation | novel | c.1703N>T | p.Gly568Val | p.G568V | Q8IVH2 | protein_coding | deleterious(0.02) | possibly_damaging(0.536) | TCGA-98-8022-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FOXP4 | SNV | Missense_Mutation | c.122N>A | p.Gly41Asp | p.G41D | Q8IVH2 | protein_coding | deleterious_low_confidence(0.05) | benign(0.056) | TCGA-98-A538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FOXP4 | SNV | Missense_Mutation | novel | c.1807N>A | p.Leu603Ile | p.L603I | Q8IVH2 | protein_coding | tolerated(0.31) | benign(0.01) | TCGA-CN-5355-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FOXP4 | SNV | Missense_Mutation | novel | c.2014N>A | p.Glu672Lys | p.E672K | Q8IVH2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.02) | TCGA-CR-6488-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FOXP4 | SNV | Missense_Mutation | c.1475N>G | p.Glu492Gly | p.E492G | Q8IVH2 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
FOXP4 | SNV | Missense_Mutation | rs140387832 | c.1117N>T | p.Arg373Trp | p.R373W | Q8IVH2 | protein_coding | deleterious(0) | possibly_damaging(0.757) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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