![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FOXJ2 |
Gene summary for FOXJ2 |
![]() |
Gene information | Species | Human | Gene symbol | FOXJ2 | Gene ID | 55810 |
Gene name | forkhead box J2 | |
Gene Alias | FHX | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9P0K8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55810 | FOXJ2 | LZE8T | Human | Esophagus | ESCC | 9.27e-03 | 1.41e-01 | 0.067 |
55810 | FOXJ2 | P1T-E | Human | Esophagus | ESCC | 4.42e-03 | 1.13e-01 | 0.0875 |
55810 | FOXJ2 | P2T-E | Human | Esophagus | ESCC | 4.01e-11 | 1.35e-01 | 0.1177 |
55810 | FOXJ2 | P4T-E | Human | Esophagus | ESCC | 2.01e-04 | 2.36e-02 | 0.1323 |
55810 | FOXJ2 | P5T-E | Human | Esophagus | ESCC | 1.12e-05 | 1.59e-02 | 0.1327 |
55810 | FOXJ2 | P8T-E | Human | Esophagus | ESCC | 4.17e-15 | 1.10e-01 | 0.0889 |
55810 | FOXJ2 | P9T-E | Human | Esophagus | ESCC | 4.98e-03 | 3.71e-02 | 0.1131 |
55810 | FOXJ2 | P10T-E | Human | Esophagus | ESCC | 1.32e-06 | 9.48e-02 | 0.116 |
55810 | FOXJ2 | P12T-E | Human | Esophagus | ESCC | 5.76e-14 | 2.57e-01 | 0.1122 |
55810 | FOXJ2 | P15T-E | Human | Esophagus | ESCC | 1.81e-07 | 9.26e-02 | 0.1149 |
55810 | FOXJ2 | P16T-E | Human | Esophagus | ESCC | 8.07e-29 | 5.12e-01 | 0.1153 |
55810 | FOXJ2 | P20T-E | Human | Esophagus | ESCC | 4.66e-04 | 4.35e-02 | 0.1124 |
55810 | FOXJ2 | P21T-E | Human | Esophagus | ESCC | 1.66e-03 | 2.22e-02 | 0.1617 |
55810 | FOXJ2 | P22T-E | Human | Esophagus | ESCC | 7.15e-14 | 1.94e-01 | 0.1236 |
55810 | FOXJ2 | P23T-E | Human | Esophagus | ESCC | 8.84e-03 | 4.01e-02 | 0.108 |
55810 | FOXJ2 | P24T-E | Human | Esophagus | ESCC | 5.96e-08 | 1.05e-01 | 0.1287 |
55810 | FOXJ2 | P26T-E | Human | Esophagus | ESCC | 2.25e-10 | 1.21e-01 | 0.1276 |
55810 | FOXJ2 | P27T-E | Human | Esophagus | ESCC | 1.29e-06 | 1.41e-01 | 0.1055 |
55810 | FOXJ2 | P28T-E | Human | Esophagus | ESCC | 4.78e-06 | 7.28e-02 | 0.1149 |
55810 | FOXJ2 | P30T-E | Human | Esophagus | ESCC | 5.03e-06 | 1.58e-01 | 0.137 |
Page: 1 2 3 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:00486597 | Esophagus | ESCC | smooth muscle cell proliferation | 103/8552 | 184/18723 | 3.08e-03 | 1.28e-02 | 103 |
GO:00486607 | Esophagus | ESCC | regulation of smooth muscle cell proliferation | 100/8552 | 180/18723 | 4.76e-03 | 1.85e-02 | 100 |
GO:00330025 | Esophagus | ESCC | muscle cell proliferation | 134/8552 | 248/18723 | 4.80e-03 | 1.86e-02 | 134 |
GO:00486615 | Esophagus | ESCC | positive regulation of smooth muscle cell proliferation | 61/8552 | 104/18723 | 5.22e-03 | 1.97e-02 | 61 |
GO:004544610 | Esophagus | ESCC | endothelial cell differentiation | 67/8552 | 118/18723 | 9.86e-03 | 3.40e-02 | 67 |
GO:000315818 | Esophagus | ESCC | endothelium development | 76/8552 | 136/18723 | 1.05e-02 | 3.59e-02 | 76 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXJ2 | SNV | Missense_Mutation | c.338N>T | p.Ser113Leu | p.S113L | Q9P0K8 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-21-5783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FOXJ2 | SNV | Missense_Mutation | c.649G>A | p.Ala217Thr | p.A217T | Q9P0K8 | protein_coding | tolerated(0.45) | benign(0) | TCGA-66-2757-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD | |
FOXJ2 | SNV | Missense_Mutation | novel | c.565N>T | p.Gly189Trp | p.G189W | Q9P0K8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-98-A538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FOXJ2 | deletion | Frame_Shift_Del | novel | c.1151delN | p.His385ThrfsTer37 | p.H385Tfs*37 | Q9P0K8 | protein_coding | TCGA-L3-A524-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
FOXJ2 | SNV | Missense_Mutation | novel | c.475N>A | p.Asp159Asn | p.D159N | Q9P0K8 | protein_coding | tolerated(0.1) | benign(0.183) | TCGA-BA-4077-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cetuximab | PD |
FOXJ2 | SNV | Missense_Mutation | novel | c.542N>T | p.Gly181Val | p.G181V | Q9P0K8 | protein_coding | tolerated(0.19) | benign(0.199) | TCGA-CR-7399-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FOXJ2 | SNV | Missense_Mutation | novel | c.193N>T | p.Gly65Cys | p.G65C | Q9P0K8 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CV-7248-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FOXJ2 | SNV | Missense_Mutation | rs143592450 | c.1481N>A | p.Arg494His | p.R494H | Q9P0K8 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FOXJ2 | SNV | Missense_Mutation | novel | c.698A>G | p.Tyr233Cys | p.Y233C | Q9P0K8 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-CV-A6JE-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FOXJ2 | SNV | Missense_Mutation | novel | c.599C>G | p.Ser200Cys | p.S200C | Q9P0K8 | protein_coding | deleterious(0.02) | benign(0.112) | TCGA-HD-A6HZ-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |