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Gene: FOCAD |
Gene summary for FOCAD |
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Gene information | Species | Human | Gene symbol | FOCAD | Gene ID | 54914 |
Gene name | focadhesin | |
Gene Alias | KIAA1797 | |
Cytomap | 9p21.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B3KNV9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54914 | FOCAD | CCI_1 | Human | Cervix | CC | 3.38e-02 | 5.13e-01 | 0.528 |
54914 | FOCAD | CCI_2 | Human | Cervix | CC | 1.22e-12 | 1.11e+00 | 0.5249 |
54914 | FOCAD | CCI_3 | Human | Cervix | CC | 9.79e-17 | 7.83e-01 | 0.516 |
54914 | FOCAD | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.49e-09 | -4.37e-01 | 0.0155 |
54914 | FOCAD | HTA11_696_2000001011 | Human | Colorectum | AD | 3.62e-06 | -3.12e-01 | -0.1464 |
54914 | FOCAD | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.87e-02 | -6.62e-01 | -0.2061 |
54914 | FOCAD | HTA11_866_3004761011 | Human | Colorectum | AD | 4.75e-03 | -3.61e-01 | 0.096 |
54914 | FOCAD | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.99e-03 | -2.93e-01 | 0.3859 |
54914 | FOCAD | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.29e-23 | -5.99e-01 | 0.3005 |
54914 | FOCAD | A002-C-010 | Human | Colorectum | FAP | 3.74e-02 | 1.69e-01 | 0.242 |
54914 | FOCAD | A015-C-203 | Human | Colorectum | FAP | 1.87e-28 | -3.70e-01 | -0.1294 |
54914 | FOCAD | A015-C-204 | Human | Colorectum | FAP | 2.49e-03 | -2.22e-01 | -0.0228 |
54914 | FOCAD | A014-C-040 | Human | Colorectum | FAP | 1.69e-02 | -2.24e-01 | -0.1184 |
54914 | FOCAD | A002-C-201 | Human | Colorectum | FAP | 6.43e-09 | -2.88e-01 | 0.0324 |
54914 | FOCAD | A001-C-119 | Human | Colorectum | FAP | 6.22e-06 | -4.26e-01 | -0.1557 |
54914 | FOCAD | A001-C-108 | Human | Colorectum | FAP | 9.09e-18 | -2.16e-01 | -0.0272 |
54914 | FOCAD | A002-C-205 | Human | Colorectum | FAP | 3.33e-20 | -4.10e-01 | -0.1236 |
54914 | FOCAD | A015-C-005 | Human | Colorectum | FAP | 2.62e-02 | -2.89e-01 | -0.0336 |
54914 | FOCAD | A015-C-006 | Human | Colorectum | FAP | 1.81e-16 | -5.51e-01 | -0.0994 |
54914 | FOCAD | A015-C-106 | Human | Colorectum | FAP | 5.13e-11 | -2.42e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOCAD | SNV | Missense_Mutation | c.2803N>T | p.Leu935Phe | p.L935F | Q5VW36 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FOCAD | SNV | Missense_Mutation | rs753108162 | c.4714N>A | p.Ala1572Thr | p.A1572T | Q5VW36 | protein_coding | tolerated(1) | benign(0.001) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FOCAD | SNV | Missense_Mutation | c.348N>C | p.Glu116Asp | p.E116D | Q5VW36 | protein_coding | tolerated(0.46) | benign(0.376) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FOCAD | SNV | Missense_Mutation | rs778930504 | c.1583N>A | p.Arg528Gln | p.R528Q | Q5VW36 | protein_coding | tolerated(0.46) | probably_damaging(0.987) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FOCAD | deletion | Frame_Shift_Del | c.2334delT | p.Phe778LeufsTer5 | p.F778Lfs*5 | Q5VW36 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
FOCAD | insertion | Frame_Shift_Ins | novel | c.1444_1445insTC | p.Asp482ValfsTer9 | p.D482Vfs*9 | Q5VW36 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FOCAD | insertion | Frame_Shift_Ins | novel | c.1445_1446insC | p.Ser483PhefsTer25 | p.S483Ffs*25 | Q5VW36 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FOCAD | SNV | Missense_Mutation | novel | c.724N>A | p.Glu242Lys | p.E242K | Q5VW36 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FOCAD | SNV | Missense_Mutation | c.3739A>C | p.Lys1247Gln | p.K1247Q | Q5VW36 | protein_coding | tolerated(0.05) | probably_damaging(0.997) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FOCAD | SNV | Missense_Mutation | c.2726T>C | p.Leu909Pro | p.L909P | Q5VW36 | protein_coding | tolerated(0.11) | possibly_damaging(0.694) | TCGA-A5-A0GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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