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Gene: FGFBP1 |
Gene summary for FGFBP1 |
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Gene information | Species | Human | Gene symbol | FGFBP1 | Gene ID | 9982 |
Gene name | fibroblast growth factor binding protein 1 | |
Gene Alias | FGF-BP | |
Cytomap | 4p15.32 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q14512 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9982 | FGFBP1 | CA_HPV_1 | Human | Cervix | CC | 3.98e-07 | -2.78e-01 | 0.0264 |
9982 | FGFBP1 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 4.06e-07 | -3.11e-01 | 0.0116 |
9982 | FGFBP1 | Tumor | Human | Cervix | CC | 2.27e-15 | 5.83e-01 | 0.1241 |
9982 | FGFBP1 | sample3 | Human | Cervix | CC | 1.92e-21 | 6.07e-01 | 0.1387 |
9982 | FGFBP1 | H2 | Human | Cervix | HSIL_HPV | 3.54e-04 | -2.60e-01 | 0.0632 |
9982 | FGFBP1 | T3 | Human | Cervix | CC | 1.43e-21 | 6.23e-01 | 0.1389 |
9982 | FGFBP1 | LZE2D | Human | Esophagus | HGIN | 5.63e-08 | -1.68e-01 | 0.0642 |
9982 | FGFBP1 | LZE5T | Human | Esophagus | ESCC | 7.14e-08 | -9.62e-01 | 0.0514 |
9982 | FGFBP1 | LZE7T | Human | Esophagus | ESCC | 3.47e-04 | 1.19e+00 | 0.0667 |
9982 | FGFBP1 | LZE8T | Human | Esophagus | ESCC | 3.03e-03 | 1.60e+00 | 0.067 |
9982 | FGFBP1 | LZE21D1 | Human | Esophagus | HGIN | 5.19e-07 | 9.89e-02 | 0.0632 |
9982 | FGFBP1 | LZE22D1 | Human | Esophagus | HGIN | 8.21e-04 | -5.30e-01 | 0.0595 |
9982 | FGFBP1 | LZE24T | Human | Esophagus | ESCC | 4.54e-07 | -9.37e-02 | 0.0596 |
9982 | FGFBP1 | LZE6T | Human | Esophagus | ESCC | 9.45e-12 | -9.22e-01 | 0.0845 |
9982 | FGFBP1 | P1T-E | Human | Esophagus | ESCC | 2.58e-06 | -7.46e-01 | 0.0875 |
9982 | FGFBP1 | P2T-E | Human | Esophagus | ESCC | 1.78e-03 | -4.42e-01 | 0.1177 |
9982 | FGFBP1 | P8T-E | Human | Esophagus | ESCC | 1.22e-08 | -3.91e-01 | 0.0889 |
9982 | FGFBP1 | P11T-E | Human | Esophagus | ESCC | 1.86e-02 | 2.18e-02 | 0.1426 |
9982 | FGFBP1 | P16T-E | Human | Esophagus | ESCC | 3.49e-28 | -9.77e-01 | 0.1153 |
9982 | FGFBP1 | P20T-E | Human | Esophagus | ESCC | 2.32e-06 | -5.90e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00506787 | Cervix | CC | regulation of epithelial cell proliferation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:00106349 | Cervix | CC | positive regulation of epithelial cell migration | 47/2311 | 176/18723 | 1.73e-07 | 8.01e-06 | 47 |
GO:00435427 | Cervix | CC | endothelial cell migration | 60/2311 | 279/18723 | 1.05e-05 | 2.33e-04 | 60 |
GO:00105944 | Cervix | CC | regulation of endothelial cell migration | 52/2311 | 232/18723 | 1.20e-05 | 2.54e-04 | 52 |
GO:00506794 | Cervix | CC | positive regulation of epithelial cell proliferation | 47/2311 | 207/18723 | 2.18e-05 | 3.90e-04 | 47 |
GO:00105954 | Cervix | CC | positive regulation of endothelial cell migration | 31/2311 | 133/18723 | 3.15e-04 | 3.35e-03 | 31 |
GO:0043534 | Cervix | CC | blood vessel endothelial cell migration | 37/2311 | 176/18723 | 7.59e-04 | 6.77e-03 | 37 |
GO:0043535 | Cervix | CC | regulation of blood vessel endothelial cell migration | 32/2311 | 151/18723 | 1.45e-03 | 1.13e-02 | 32 |
GO:0043536 | Cervix | CC | positive regulation of blood vessel endothelial cell migration | 18/2311 | 76/18723 | 4.45e-03 | 2.71e-02 | 18 |
GO:001063113 | Cervix | HSIL_HPV | epithelial cell migration | 33/737 | 357/18723 | 5.28e-06 | 2.04e-04 | 33 |
GO:000166715 | Cervix | HSIL_HPV | ameboidal-type cell migration | 40/737 | 475/18723 | 5.48e-06 | 2.07e-04 | 40 |
GO:009013213 | Cervix | HSIL_HPV | epithelium migration | 33/737 | 360/18723 | 6.31e-06 | 2.29e-04 | 33 |
GO:009013013 | Cervix | HSIL_HPV | tissue migration | 33/737 | 365/18723 | 8.43e-06 | 2.97e-04 | 33 |
GO:005067314 | Cervix | HSIL_HPV | epithelial cell proliferation | 34/737 | 437/18723 | 1.31e-04 | 2.61e-03 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FGFBP1 | deletion | Frame_Shift_Del | rs562275732 | c.78delN | p.Val27Ter | p.V27* | Q14512 | protein_coding | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
FGFBP1 | deletion | Frame_Shift_Del | rs562275732 | c.78delN | p.Val27Ter | p.V27* | Q14512 | protein_coding | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
FGFBP1 | deletion | Frame_Shift_Del | c.77_78delNN | p.Lys26SerfsTer23 | p.K26Sfs*23 | Q14512 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |||
FGFBP1 | deletion | Frame_Shift_Del | rs562275732 | c.78delN | p.Val27Ter | p.V27* | Q14512 | protein_coding | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FGFBP1 | deletion | Frame_Shift_Del | rs562275732 | c.78delN | p.Val27Ter | p.V27* | Q14512 | protein_coding | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
FGFBP1 | deletion | Frame_Shift_Del | rs562275732 | c.78delA | p.Val27Ter | p.V27* | Q14512 | protein_coding | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | ||
FGFBP1 | deletion | Frame_Shift_Del | rs562275732 | c.78delN | p.Val27Ter | p.V27* | Q14512 | protein_coding | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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