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Gene: FEM1B |
Gene summary for FEM1B |
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Gene information | Species | Human | Gene symbol | FEM1B | Gene ID | 10116 |
Gene name | fem-1 homolog B | |
Gene Alias | F1A-ALPHA | |
Cytomap | 15q23 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UK73 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10116 | FEM1B | LZE4T | Human | Esophagus | ESCC | 1.02e-04 | 3.26e-01 | 0.0811 |
10116 | FEM1B | LZE7T | Human | Esophagus | ESCC | 2.74e-06 | 1.54e-01 | 0.0667 |
10116 | FEM1B | LZE8T | Human | Esophagus | ESCC | 3.79e-03 | -4.09e-02 | 0.067 |
10116 | FEM1B | LZE24T | Human | Esophagus | ESCC | 1.49e-13 | 1.52e-01 | 0.0596 |
10116 | FEM1B | LZE21T | Human | Esophagus | ESCC | 6.82e-09 | 1.69e-01 | 0.0655 |
10116 | FEM1B | LZE6T | Human | Esophagus | ESCC | 7.51e-03 | 7.36e-03 | 0.0845 |
10116 | FEM1B | P1T-E | Human | Esophagus | ESCC | 9.78e-10 | 2.98e-01 | 0.0875 |
10116 | FEM1B | P2T-E | Human | Esophagus | ESCC | 1.98e-23 | 4.72e-01 | 0.1177 |
10116 | FEM1B | P4T-E | Human | Esophagus | ESCC | 2.81e-15 | 4.08e-01 | 0.1323 |
10116 | FEM1B | P5T-E | Human | Esophagus | ESCC | 1.29e-09 | 2.75e-01 | 0.1327 |
10116 | FEM1B | P8T-E | Human | Esophagus | ESCC | 5.31e-22 | 2.41e-01 | 0.0889 |
10116 | FEM1B | P9T-E | Human | Esophagus | ESCC | 9.72e-13 | 3.91e-01 | 0.1131 |
10116 | FEM1B | P10T-E | Human | Esophagus | ESCC | 9.57e-25 | 4.08e-01 | 0.116 |
10116 | FEM1B | P11T-E | Human | Esophagus | ESCC | 3.04e-06 | 2.69e-01 | 0.1426 |
10116 | FEM1B | P12T-E | Human | Esophagus | ESCC | 2.43e-24 | 4.34e-01 | 0.1122 |
10116 | FEM1B | P15T-E | Human | Esophagus | ESCC | 4.30e-23 | 5.82e-01 | 0.1149 |
10116 | FEM1B | P16T-E | Human | Esophagus | ESCC | 3.16e-21 | 4.49e-01 | 0.1153 |
10116 | FEM1B | P20T-E | Human | Esophagus | ESCC | 1.06e-07 | 8.26e-02 | 0.1124 |
10116 | FEM1B | P21T-E | Human | Esophagus | ESCC | 7.92e-16 | 1.31e-01 | 0.1617 |
10116 | FEM1B | P22T-E | Human | Esophagus | ESCC | 5.36e-15 | 1.82e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:0097191111 | Esophagus | ESCC | extrinsic apoptotic signaling pathway | 159/8552 | 219/18723 | 4.12e-16 | 2.94e-14 | 159 |
GO:2001236111 | Esophagus | ESCC | regulation of extrinsic apoptotic signaling pathway | 111/8552 | 151/18723 | 2.97e-12 | 1.18e-10 | 111 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:004277014 | Esophagus | ESCC | signal transduction in response to DNA damage | 117/8552 | 172/18723 | 2.38e-09 | 5.32e-08 | 117 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:00315705 | Esophagus | ESCC | DNA integrity checkpoint | 83/8552 | 123/18723 | 8.17e-07 | 1.06e-05 | 83 |
GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
GO:000862519 | Esophagus | ESCC | extrinsic apoptotic signaling pathway via death domain receptors | 59/8552 | 82/18723 | 1.23e-06 | 1.52e-05 | 59 |
GO:00000775 | Esophagus | ESCC | DNA damage checkpoint | 78/8552 | 115/18723 | 1.27e-06 | 1.56e-05 | 78 |
GO:19019883 | Esophagus | ESCC | negative regulation of cell cycle phase transition | 151/8552 | 249/18723 | 1.28e-06 | 1.57e-05 | 151 |
GO:002261216 | Esophagus | ESCC | gland morphogenesis | 78/8552 | 118/18723 | 5.83e-06 | 6.03e-05 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FEM1B | SNV | Missense_Mutation | novel | c.347A>C | p.His116Pro | p.H116P | Q9UK73 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FEM1B | SNV | Missense_Mutation | novel | c.170N>A | p.Gly57Glu | p.G57E | Q9UK73 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FEM1B | insertion | Frame_Shift_Ins | novel | c.868_869insTTCTCGAAAAAGAGGTTCTTCCACCGACCAAGACCTCACTCTCCAGAACATTAATAAAACATCAG | p.Ile299ThrfsTer54 | p.I299Tfs*54 | Q9UK73 | protein_coding | TCGA-B5-A11F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
FEM1B | insertion | Frame_Shift_Ins | novel | c.1780_1781insAC | p.Lys594AsnfsTer3 | p.K594Nfs*3 | Q9UK73 | protein_coding | TCGA-D1-A0ZZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | SD | ||
FEM1B | insertion | Frame_Shift_Ins | novel | c.1782_1783insATAAC | p.Met595IlefsTer3 | p.M595Ifs*3 | Q9UK73 | protein_coding | TCGA-D1-A0ZZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | SD | ||
FEM1B | SNV | Missense_Mutation | c.1682A>C | p.Glu561Ala | p.E561A | Q9UK73 | protein_coding | deleterious(0.01) | possibly_damaging(0.808) | TCGA-35-4122-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FEM1B | SNV | Missense_Mutation | novel | c.791N>T | p.Arg264Leu | p.R264L | Q9UK73 | protein_coding | deleterious(0) | benign(0.35) | TCGA-49-AARO-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
FEM1B | SNV | Missense_Mutation | rs781435603 | c.1312N>T | p.Asp438Tyr | p.D438Y | Q9UK73 | protein_coding | deleterious(0) | possibly_damaging(0.646) | TCGA-49-AARO-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
FEM1B | SNV | Missense_Mutation | novel | c.1495G>A | p.Asp499Asn | p.D499N | Q9UK73 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-99-8032-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FEM1B | SNV | Missense_Mutation | novel | c.857N>G | p.Asp286Gly | p.D286G | Q9UK73 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-22-4596-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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