![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FAM81B |
Gene summary for FAM81B |
![]() |
Gene information | Species | Human | Gene symbol | FAM81B | Gene ID | 153643 |
Gene name | family with sequence similarity 81 member B | |
Gene Alias | FAM81B | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96LP2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153643 | FAM81B | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 4.12e-03 | 5.90e-01 | -0.0186 |
153643 | FAM81B | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.47e-02 | 4.97e-01 | -0.0296 |
153643 | FAM81B | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 5.54e-03 | 5.18e-01 | -0.0263 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM81B | SNV | Missense_Mutation | rs756787447 | c.1102N>G | p.Gln368Glu | p.Q368E | Q96LP2 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-44-A4SS-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | novel | c.592N>A | p.Ala198Thr | p.A198T | Q96LP2 | protein_coding | tolerated(0.07) | benign(0.444) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | novel | c.685N>A | p.Gly229Arg | p.G229R | Q96LP2 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-94-7033-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
FAM81B | SNV | Missense_Mutation | novel | c.1068N>C | p.Gln356His | p.Q356H | Q96LP2 | protein_coding | tolerated(0.51) | benign(0.044) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | rs200794195 | c.461N>T | p.Ser154Leu | p.S154L | Q96LP2 | protein_coding | tolerated(0.22) | benign(0.078) | TCGA-CH-5792-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | rs370398727 | c.922G>A | p.Glu308Lys | p.E308K | Q96LP2 | protein_coding | tolerated(0.09) | possibly_damaging(0.534) | TCGA-EJ-A46F-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | PD |
FAM81B | SNV | Missense_Mutation | c.245N>T | p.Ala82Val | p.A82V | Q96LP2 | protein_coding | tolerated(0.09) | benign(0.05) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM81B | SNV | Missense_Mutation | rs770077907 | c.751N>A | p.Ala251Thr | p.A251T | Q96LP2 | protein_coding | tolerated(0.19) | benign(0.103) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | c.293A>T | p.Lys98Met | p.K98M | Q96LP2 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
FAM81B | SNV | Missense_Mutation | c.426N>G | p.Cys142Trp | p.C142W | Q96LP2 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-D7-A4YU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |