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Gene: FAM214B |
Gene summary for FAM214B |
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Gene information | Species | Human | Gene symbol | FAM214B | Gene ID | 80256 |
Gene name | family with sequence similarity 214 member B | |
Gene Alias | KIAA1539 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q7L5A3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80256 | FAM214B | C21 | Human | Oral cavity | OSCC | 4.61e-10 | 3.31e-01 | 0.2678 |
80256 | FAM214B | C30 | Human | Oral cavity | OSCC | 3.58e-18 | 1.08e+00 | 0.3055 |
80256 | FAM214B | C38 | Human | Oral cavity | OSCC | 3.43e-02 | 4.30e-01 | 0.172 |
80256 | FAM214B | C51 | Human | Oral cavity | OSCC | 9.69e-04 | 3.81e-01 | 0.2674 |
80256 | FAM214B | C06 | Human | Oral cavity | OSCC | 1.08e-09 | 1.18e+00 | 0.2699 |
80256 | FAM214B | SYSMH1 | Human | Oral cavity | OSCC | 2.28e-09 | 1.97e-01 | 0.1127 |
80256 | FAM214B | SYSMH3 | Human | Oral cavity | OSCC | 2.20e-10 | 3.11e-01 | 0.2442 |
80256 | FAM214B | SYSMH6 | Human | Oral cavity | OSCC | 4.25e-04 | 1.19e-01 | 0.1275 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM214B | SNV | Missense_Mutation | rs573042192 | c.965N>A | p.Arg322Gln | p.R322Q | Q7L5A3 | protein_coding | deleterious(0.02) | possibly_damaging(0.805) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM214B | SNV | Missense_Mutation | c.263G>A | p.Arg88Lys | p.R88K | Q7L5A3 | protein_coding | tolerated(0.08) | benign(0.13) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAM214B | SNV | Missense_Mutation | c.623N>T | p.Gly208Val | p.G208V | Q7L5A3 | protein_coding | deleterious(0) | benign(0.174) | TCGA-55-1596-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
FAM214B | SNV | Missense_Mutation | c.622N>T | p.Gly208Trp | p.G208W | Q7L5A3 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-55-1596-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
FAM214B | SNV | Missense_Mutation | c.1172N>G | p.Val391Gly | p.V391G | Q7L5A3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-97-7937-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM214B | SNV | Missense_Mutation | c.227N>T | p.Pro76Leu | p.P76L | Q7L5A3 | protein_coding | deleterious_low_confidence(0.03) | benign(0.013) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
FAM214B | SNV | Missense_Mutation | novel | c.628N>T | p.Ser210Cys | p.S210C | Q7L5A3 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.466) | TCGA-60-2714-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
FAM214B | insertion | Frame_Shift_Ins | novel | c.1394_1395insT | p.Leu465PhefsTer6 | p.L465Ffs*6 | Q7L5A3 | protein_coding | TCGA-92-8063-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | taxol | SD | ||
FAM214B | SNV | Missense_Mutation | novel | c.434G>A | p.Cys145Tyr | p.C145Y | Q7L5A3 | protein_coding | tolerated_low_confidence(0.14) | benign(0.006) | TCGA-BA-6869-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
FAM214B | SNV | Missense_Mutation | novel | c.517N>A | p.Glu173Lys | p.E173K | Q7L5A3 | protein_coding | tolerated(0.06) | benign(0.01) | TCGA-CR-7371-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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