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Gene: FAM200B |
Gene summary for FAM200B |
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Gene information | Species | Human | Gene symbol | FAM200B | Gene ID | 285550 |
Gene name | family with sequence similarity 200 member B | |
Gene Alias | C4orf53 | |
Cytomap | 4p15.32 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | P0CF97 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285550 | FAM200B | LZE4T | Human | Esophagus | ESCC | 2.07e-03 | 5.54e-03 | 0.0811 |
285550 | FAM200B | LZE20T | Human | Esophagus | ESCC | 1.01e-02 | 1.25e-01 | 0.0662 |
285550 | FAM200B | LZE22T | Human | Esophagus | ESCC | 9.19e-06 | 2.59e-01 | 0.068 |
285550 | FAM200B | LZE24T | Human | Esophagus | ESCC | 2.95e-12 | 3.48e-01 | 0.0596 |
285550 | FAM200B | LZE21T | Human | Esophagus | ESCC | 8.29e-04 | 8.84e-02 | 0.0655 |
285550 | FAM200B | P1T-E | Human | Esophagus | ESCC | 9.23e-05 | 4.94e-01 | 0.0875 |
285550 | FAM200B | P2T-E | Human | Esophagus | ESCC | 3.08e-28 | 6.19e-01 | 0.1177 |
285550 | FAM200B | P4T-E | Human | Esophagus | ESCC | 1.63e-19 | 5.43e-01 | 0.1323 |
285550 | FAM200B | P5T-E | Human | Esophagus | ESCC | 2.89e-14 | 9.54e-02 | 0.1327 |
285550 | FAM200B | P8T-E | Human | Esophagus | ESCC | 1.53e-28 | 7.06e-01 | 0.0889 |
285550 | FAM200B | P9T-E | Human | Esophagus | ESCC | 1.05e-18 | 5.23e-01 | 0.1131 |
285550 | FAM200B | P10T-E | Human | Esophagus | ESCC | 2.45e-24 | 5.90e-01 | 0.116 |
285550 | FAM200B | P11T-E | Human | Esophagus | ESCC | 1.02e-10 | 5.42e-01 | 0.1426 |
285550 | FAM200B | P12T-E | Human | Esophagus | ESCC | 2.13e-31 | 7.00e-01 | 0.1122 |
285550 | FAM200B | P15T-E | Human | Esophagus | ESCC | 5.37e-09 | 2.21e-01 | 0.1149 |
285550 | FAM200B | P16T-E | Human | Esophagus | ESCC | 9.52e-21 | 5.32e-01 | 0.1153 |
285550 | FAM200B | P17T-E | Human | Esophagus | ESCC | 4.02e-02 | 4.25e-01 | 0.1278 |
285550 | FAM200B | P19T-E | Human | Esophagus | ESCC | 4.04e-06 | 6.85e-01 | 0.1662 |
285550 | FAM200B | P20T-E | Human | Esophagus | ESCC | 2.41e-08 | 3.48e-01 | 0.1124 |
285550 | FAM200B | P21T-E | Human | Esophagus | ESCC | 2.57e-14 | 4.46e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM200B | SNV | Missense_Mutation | rs141613449 | c.835C>T | p.Arg279Cys | p.R279C | P0CF97 | protein_coding | tolerated(0.19) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM200B | SNV | Missense_Mutation | novel | c.1748T>G | p.Phe583Cys | p.F583C | P0CF97 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM200B | SNV | Missense_Mutation | novel | c.1330N>G | p.Leu444Val | p.L444V | P0CF97 | protein_coding | tolerated(0.41) | benign(0.425) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
FAM200B | SNV | Missense_Mutation | novel | c.277N>T | p.Leu93Phe | p.L93F | P0CF97 | protein_coding | deleterious(0.05) | probably_damaging(1) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM200B | SNV | Missense_Mutation | novel | c.1678A>G | p.Asn560Asp | p.N560D | P0CF97 | protein_coding | tolerated(0.89) | benign(0.005) | TCGA-FI-A2D4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FAM200B | SNV | Missense_Mutation | rs188407400 | c.1159N>T | p.Arg387Cys | p.R387C | P0CF97 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FAM200B | insertion | Frame_Shift_Ins | novel | c.1862_1863insA | p.Thr623AsnfsTer26 | p.T623Nfs*26 | P0CF97 | protein_coding | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAM200B | insertion | Frame_Shift_Ins | novel | c.164dupA | p.Lys56GlufsTer9 | p.K56Efs*9 | P0CF97 | protein_coding | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAM200B | deletion | Frame_Shift_Del | c.503delN | p.Ile170LeufsTer22 | p.I170Lfs*22 | P0CF97 | protein_coding | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
FAM200B | deletion | Frame_Shift_Del | novel | c.773delT | p.Leu258CysfsTer4 | p.L258Cfs*4 | P0CF97 | protein_coding | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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