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Gene: FAM198B |
Gene summary for FAM198B |
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Gene information | Species | Human | Gene symbol | FAM198B | Gene ID | 51313 |
Gene name | golgi associated kinase 1B | |
Gene Alias | AD021 | |
Cytomap | 4q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000139 | UniProtAcc | Q6UWH4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51313 | FAM198B | GSM4909298 | Human | Breast | IDC | 5.80e-22 | 4.09e-01 | 0.1551 |
51313 | FAM198B | GSM4909304 | Human | Breast | IDC | 5.74e-24 | 5.25e-01 | 0.1636 |
51313 | FAM198B | M5 | Human | Breast | IDC | 6.26e-07 | 6.83e-01 | 0.1598 |
51313 | FAM198B | P4T-E | Human | Esophagus | ESCC | 1.43e-04 | 2.60e-01 | 0.1323 |
51313 | FAM198B | P5T-E | Human | Esophagus | ESCC | 1.94e-02 | 1.62e-01 | 0.1327 |
51313 | FAM198B | P8T-E | Human | Esophagus | ESCC | 3.24e-11 | 3.47e-01 | 0.0889 |
51313 | FAM198B | P9T-E | Human | Esophagus | ESCC | 1.66e-04 | 2.95e-01 | 0.1131 |
51313 | FAM198B | P11T-E | Human | Esophagus | ESCC | 6.58e-06 | 5.71e-01 | 0.1426 |
51313 | FAM198B | P12T-E | Human | Esophagus | ESCC | 7.54e-03 | 1.87e-01 | 0.1122 |
51313 | FAM198B | P32T-E | Human | Esophagus | ESCC | 3.81e-04 | 3.19e-01 | 0.1666 |
51313 | FAM198B | P37T-E | Human | Esophagus | ESCC | 1.28e-02 | 1.44e-01 | 0.1371 |
51313 | FAM198B | P42T-E | Human | Esophagus | ESCC | 3.98e-04 | 5.25e-01 | 0.1175 |
51313 | FAM198B | P44T-E | Human | Esophagus | ESCC | 2.76e-05 | 3.02e-01 | 0.1096 |
51313 | FAM198B | P61T-E | Human | Esophagus | ESCC | 9.05e-14 | 4.45e-01 | 0.099 |
51313 | FAM198B | P79T-E | Human | Esophagus | ESCC | 9.38e-03 | 7.83e-02 | 0.1154 |
51313 | FAM198B | P107T-E | Human | Esophagus | ESCC | 2.29e-03 | 1.21e-01 | 0.171 |
51313 | FAM198B | ATC12 | Human | Thyroid | ATC | 1.45e-16 | 3.77e-01 | 0.34 |
51313 | FAM198B | ATC2 | Human | Thyroid | ATC | 2.12e-15 | 1.65e+00 | 0.34 |
51313 | FAM198B | ATC4 | Human | Thyroid | ATC | 1.33e-16 | 4.70e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM198B | SNV | Missense_Mutation | novel | c.891G>T | p.Arg297Ser | p.R297S | Q6UWH4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DD-AAVZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM198B | SNV | Missense_Mutation | novel | c.890G>T | p.Arg297Met | p.R297M | Q6UWH4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DD-AAVZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM198B | SNV | Missense_Mutation | novel | c.1180G>C | p.Gly394Arg | p.G394R | Q6UWH4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-4112-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
FAM198B | SNV | Missense_Mutation | c.138C>G | p.Ile46Met | p.I46M | Q6UWH4 | protein_coding | tolerated(0.1) | possibly_damaging(0.684) | TCGA-44-A4SS-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM198B | SNV | Missense_Mutation | novel | c.1543N>G | p.Ile515Val | p.I515V | Q6UWH4 | protein_coding | deleterious(0.01) | probably_damaging(0.947) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
FAM198B | SNV | Missense_Mutation | c.1281N>T | p.Lys427Asn | p.K427N | Q6UWH4 | protein_coding | tolerated(0.19) | benign(0.234) | TCGA-18-3419-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM198B | SNV | Missense_Mutation | c.1149N>T | p.Gln383His | p.Q383H | Q6UWH4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
FAM198B | SNV | Missense_Mutation | novel | c.57N>G | p.Cys19Trp | p.C19W | Q6UWH4 | protein_coding | deleterious(0.02) | benign(0.033) | TCGA-22-4609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM198B | SNV | Missense_Mutation | novel | c.819N>A | p.Asp273Glu | p.D273E | Q6UWH4 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-43-2578-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM198B | SNV | Missense_Mutation | novel | c.434N>C | p.Leu145Ser | p.L145S | Q6UWH4 | protein_coding | tolerated(0.36) | benign(0.044) | TCGA-56-8309-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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