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Gene: FAM173B |
Gene summary for FAM173B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FAM173B | Gene ID | 134145 |
| Gene name | ATP synthase c subunit lysine N-methyltransferase | |
| Gene Alias | FAM173B | |
| Cytomap | 5p15.2 | |
| Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q6P4H8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 134145 | FAM173B | P1T-E | Human | Esophagus | ESCC | 2.64e-09 | 2.61e-01 | 0.0875 |
| 134145 | FAM173B | P2T-E | Human | Esophagus | ESCC | 9.60e-10 | 1.09e-01 | 0.1177 |
| 134145 | FAM173B | P4T-E | Human | Esophagus | ESCC | 6.74e-20 | 3.74e-01 | 0.1323 |
| 134145 | FAM173B | P5T-E | Human | Esophagus | ESCC | 1.49e-11 | 1.82e-01 | 0.1327 |
| 134145 | FAM173B | P8T-E | Human | Esophagus | ESCC | 1.98e-13 | 1.86e-01 | 0.0889 |
| 134145 | FAM173B | P9T-E | Human | Esophagus | ESCC | 1.46e-04 | 1.37e-01 | 0.1131 |
| 134145 | FAM173B | P10T-E | Human | Esophagus | ESCC | 3.24e-15 | 1.94e-01 | 0.116 |
| 134145 | FAM173B | P12T-E | Human | Esophagus | ESCC | 5.48e-17 | 2.01e-01 | 0.1122 |
| 134145 | FAM173B | P15T-E | Human | Esophagus | ESCC | 5.09e-09 | 1.28e-01 | 0.1149 |
| 134145 | FAM173B | P16T-E | Human | Esophagus | ESCC | 1.65e-09 | 8.15e-02 | 0.1153 |
| 134145 | FAM173B | P20T-E | Human | Esophagus | ESCC | 1.77e-10 | 1.13e-01 | 0.1124 |
| 134145 | FAM173B | P21T-E | Human | Esophagus | ESCC | 3.66e-15 | 1.95e-01 | 0.1617 |
| 134145 | FAM173B | P22T-E | Human | Esophagus | ESCC | 4.98e-03 | 3.72e-02 | 0.1236 |
| 134145 | FAM173B | P23T-E | Human | Esophagus | ESCC | 9.77e-08 | 1.41e-01 | 0.108 |
| 134145 | FAM173B | P24T-E | Human | Esophagus | ESCC | 4.64e-07 | 3.66e-02 | 0.1287 |
| 134145 | FAM173B | P26T-E | Human | Esophagus | ESCC | 2.88e-05 | 1.31e-01 | 0.1276 |
| 134145 | FAM173B | P27T-E | Human | Esophagus | ESCC | 6.50e-13 | 2.61e-01 | 0.1055 |
| 134145 | FAM173B | P28T-E | Human | Esophagus | ESCC | 1.05e-10 | 8.38e-02 | 0.1149 |
| 134145 | FAM173B | P30T-E | Human | Esophagus | ESCC | 6.93e-09 | 2.91e-01 | 0.137 |
| 134145 | FAM173B | P31T-E | Human | Esophagus | ESCC | 3.38e-23 | 1.92e-01 | 0.1251 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FAM173B | insertion | Frame_Shift_Ins | novel | c.516_517insAACACTCCCAGTAAAGTTTATG | p.Leu173AsnfsTer9 | p.L173Nfs*9 | Q6P4H8 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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