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Gene: FAM160A2 |
Gene summary for FAM160A2 |
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Gene information | Species | Human | Gene symbol | FAM160A2 | Gene ID | 84067 |
Gene name | FHF complex subunit HOOK interacting protein 1B | |
Gene Alias | C11orf56 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8N612 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84067 | FAM160A2 | LZE24T | Human | Esophagus | ESCC | 1.16e-10 | 4.05e-01 | 0.0596 |
84067 | FAM160A2 | P2T-E | Human | Esophagus | ESCC | 5.45e-21 | 1.70e-01 | 0.1177 |
84067 | FAM160A2 | P4T-E | Human | Esophagus | ESCC | 8.73e-05 | 1.26e-02 | 0.1323 |
84067 | FAM160A2 | P5T-E | Human | Esophagus | ESCC | 1.22e-11 | 6.00e-02 | 0.1327 |
84067 | FAM160A2 | P8T-E | Human | Esophagus | ESCC | 4.01e-13 | 7.89e-02 | 0.0889 |
84067 | FAM160A2 | P9T-E | Human | Esophagus | ESCC | 2.44e-02 | 1.90e-02 | 0.1131 |
84067 | FAM160A2 | P10T-E | Human | Esophagus | ESCC | 2.18e-17 | 1.53e-01 | 0.116 |
84067 | FAM160A2 | P11T-E | Human | Esophagus | ESCC | 1.01e-13 | 4.89e-01 | 0.1426 |
84067 | FAM160A2 | P12T-E | Human | Esophagus | ESCC | 8.20e-18 | 1.71e-01 | 0.1122 |
84067 | FAM160A2 | P15T-E | Human | Esophagus | ESCC | 1.55e-13 | 2.25e-01 | 0.1149 |
84067 | FAM160A2 | P16T-E | Human | Esophagus | ESCC | 6.60e-08 | 8.59e-02 | 0.1153 |
84067 | FAM160A2 | P17T-E | Human | Esophagus | ESCC | 5.08e-03 | 7.81e-02 | 0.1278 |
84067 | FAM160A2 | P20T-E | Human | Esophagus | ESCC | 4.50e-13 | 2.18e-01 | 0.1124 |
84067 | FAM160A2 | P21T-E | Human | Esophagus | ESCC | 1.04e-10 | 1.16e-01 | 0.1617 |
84067 | FAM160A2 | P22T-E | Human | Esophagus | ESCC | 2.08e-17 | 8.17e-02 | 0.1236 |
84067 | FAM160A2 | P23T-E | Human | Esophagus | ESCC | 2.75e-11 | 1.39e-01 | 0.108 |
84067 | FAM160A2 | P24T-E | Human | Esophagus | ESCC | 4.20e-05 | 5.68e-02 | 0.1287 |
84067 | FAM160A2 | P26T-E | Human | Esophagus | ESCC | 1.98e-11 | 1.50e-01 | 0.1276 |
84067 | FAM160A2 | P27T-E | Human | Esophagus | ESCC | 2.90e-13 | 1.90e-01 | 0.1055 |
84067 | FAM160A2 | P28T-E | Human | Esophagus | ESCC | 9.77e-19 | 3.94e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM160A2 | SNV | Missense_Mutation | rs760692181 | c.157N>T | p.Arg53Trp | p.R53W | Q8N612 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM160A2 | SNV | Missense_Mutation | novel | c.193N>A | p.Asp65Asn | p.D65N | Q8N612 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
FAM160A2 | SNV | Missense_Mutation | c.2783N>A | p.Arg928His | p.R928H | Q8N612 | protein_coding | tolerated(0.07) | possibly_damaging(0.784) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FAM160A2 | SNV | Missense_Mutation | rs746348224 | c.2311N>A | p.Val771Ile | p.V771I | Q8N612 | protein_coding | tolerated(0.16) | benign(0.038) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FAM160A2 | SNV | Missense_Mutation | rs147077635 | c.1393N>A | p.Ala465Thr | p.A465T | Q8N612 | protein_coding | tolerated(0.2) | benign(0.036) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FAM160A2 | SNV | Missense_Mutation | c.1099C>T | p.Leu367Phe | p.L367F | Q8N612 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
FAM160A2 | SNV | Missense_Mutation | c.2950N>A | p.Leu984Ile | p.L984I | Q8N612 | protein_coding | deleterious_low_confidence(0.04) | benign(0.099) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM160A2 | SNV | Missense_Mutation | novel | c.2716N>T | p.Gly906Cys | p.G906C | Q8N612 | protein_coding | deleterious(0.01) | benign(0.046) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
FAM160A2 | SNV | Missense_Mutation | rs746348224 | c.2311N>A | p.Val771Ile | p.V771I | Q8N612 | protein_coding | tolerated(0.16) | benign(0.038) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM160A2 | SNV | Missense_Mutation | novel | c.2428N>A | p.Leu810Met | p.L810M | Q8N612 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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