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Gene: FAM129B |
Gene summary for FAM129B |
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Gene information | Species | Human | Gene symbol | FAM129B | Gene ID | 64855 |
Gene name | niban apoptosis regulator 2 | |
Gene Alias | C9orf88 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R872 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64855 | FAM129B | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.18e-16 | -3.90e-01 | 0.0155 |
64855 | FAM129B | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.85e-09 | -3.90e-01 | -0.1808 |
64855 | FAM129B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.06e-06 | -3.90e-01 | -0.0811 |
64855 | FAM129B | HTA11_78_2000001011 | Human | Colorectum | AD | 1.03e-10 | -3.90e-01 | -0.1088 |
64855 | FAM129B | HTA11_347_2000001011 | Human | Colorectum | AD | 3.32e-17 | -3.90e-01 | -0.1954 |
64855 | FAM129B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.02e-06 | -3.90e-01 | -0.1207 |
64855 | FAM129B | HTA11_83_2000001011 | Human | Colorectum | SER | 4.39e-05 | -3.90e-01 | -0.1526 |
64855 | FAM129B | HTA11_696_2000001011 | Human | Colorectum | AD | 3.31e-19 | -3.90e-01 | -0.1464 |
64855 | FAM129B | HTA11_866_2000001011 | Human | Colorectum | AD | 4.78e-17 | -3.90e-01 | -0.1001 |
64855 | FAM129B | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.15e-12 | -3.90e-01 | -0.059 |
64855 | FAM129B | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.96e-02 | -3.90e-01 | -0.2061 |
64855 | FAM129B | HTA11_546_2000001011 | Human | Colorectum | AD | 3.46e-04 | -3.90e-01 | -0.0842 |
64855 | FAM129B | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.34e-03 | -3.90e-01 | -0.0179 |
64855 | FAM129B | HTA11_866_3004761011 | Human | Colorectum | AD | 6.48e-14 | -3.90e-01 | 0.096 |
64855 | FAM129B | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.67e-02 | -3.90e-01 | 0.0528 |
64855 | FAM129B | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.91e-03 | -3.90e-01 | -0.0177 |
64855 | FAM129B | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.48e-08 | -3.90e-01 | 0.0338 |
64855 | FAM129B | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.78e-17 | -3.90e-01 | 0.0674 |
64855 | FAM129B | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.30e-03 | -3.90e-01 | 0.0112 |
64855 | FAM129B | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.99e-06 | -3.90e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM129B | SNV | Missense_Mutation | c.132G>A | p.Met44Ile | p.M44I | Q96TA1 | protein_coding | tolerated(0.23) | benign(0.01) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
FAM129B | SNV | Missense_Mutation | novel | c.1090N>A | p.Val364Ile | p.V364I | Q96TA1 | protein_coding | tolerated(0.07) | benign(0.023) | TCGA-66-2766-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
FAM129B | SNV | Missense_Mutation | rs370720142 | c.289G>T | p.Gly97Trp | p.G97W | Q96TA1 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-94-8035-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unspecific | Complete Response | |
FAM129B | SNV | Missense_Mutation | novel | c.1594N>A | p.Leu532Met | p.L532M | Q96TA1 | protein_coding | tolerated(0.09) | probably_damaging(0.911) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
FAM129B | SNV | Missense_Mutation | novel | c.1629G>C | p.Gln543His | p.Q543H | Q96TA1 | protein_coding | tolerated(0.08) | benign(0.069) | TCGA-CR-5248-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
FAM129B | SNV | Missense_Mutation | c.1826N>T | p.Ser609Leu | p.S609L | Q96TA1 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-CV-7104-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM129B | SNV | Missense_Mutation | rs780212910 | c.1340C>T | p.Thr447Met | p.T447M | Q96TA1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-UF-A7JT-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
FAM129B | SNV | Missense_Mutation | c.524T>C | p.Met175Thr | p.M175T | Q96TA1 | protein_coding | tolerated(0.45) | benign(0.082) | TCGA-J4-A67L-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
FAM129B | SNV | Missense_Mutation | rs371821621 | c.181N>T | p.Arg61Cys | p.R61C | Q96TA1 | protein_coding | deleterious(0.02) | possibly_damaging(0.847) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
FAM129B | SNV | Missense_Mutation | novel | c.2166G>T | p.Gln722His | p.Q722H | Q96TA1 | protein_coding | deleterious_low_confidence(0.04) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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