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Gene: EYA3 |
Gene summary for EYA3 |
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Gene information | Species | Human | Gene symbol | EYA3 | Gene ID | 2140 |
Gene name | EYA transcriptional coactivator and phosphatase 3 | |
Gene Alias | EYA3 | |
Cytomap | 1p35.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q99504 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2140 | EYA3 | CCI_1 | Human | Cervix | CC | 4.62e-05 | 5.95e-01 | 0.528 |
2140 | EYA3 | CCI_2 | Human | Cervix | CC | 4.77e-06 | 7.15e-01 | 0.5249 |
2140 | EYA3 | CCI_3 | Human | Cervix | CC | 1.97e-10 | 6.25e-01 | 0.516 |
2140 | EYA3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.43e-04 | -3.57e-01 | 0.3005 |
2140 | EYA3 | F007 | Human | Colorectum | FAP | 4.08e-02 | -2.85e-01 | 0.1176 |
2140 | EYA3 | A001-C-207 | Human | Colorectum | FAP | 2.64e-04 | -3.13e-01 | 0.1278 |
2140 | EYA3 | A015-C-203 | Human | Colorectum | FAP | 1.34e-24 | -4.19e-01 | -0.1294 |
2140 | EYA3 | A015-C-204 | Human | Colorectum | FAP | 1.41e-05 | -2.68e-01 | -0.0228 |
2140 | EYA3 | A014-C-040 | Human | Colorectum | FAP | 1.90e-04 | -4.25e-01 | -0.1184 |
2140 | EYA3 | A002-C-201 | Human | Colorectum | FAP | 3.68e-15 | -3.97e-01 | 0.0324 |
2140 | EYA3 | A002-C-203 | Human | Colorectum | FAP | 4.07e-04 | -2.76e-01 | 0.2786 |
2140 | EYA3 | A001-C-119 | Human | Colorectum | FAP | 1.93e-05 | -3.33e-01 | -0.1557 |
2140 | EYA3 | A001-C-108 | Human | Colorectum | FAP | 1.44e-17 | -4.27e-01 | -0.0272 |
2140 | EYA3 | A002-C-205 | Human | Colorectum | FAP | 2.56e-23 | -5.11e-01 | -0.1236 |
2140 | EYA3 | A001-C-104 | Human | Colorectum | FAP | 2.42e-03 | -2.45e-01 | 0.0184 |
2140 | EYA3 | A015-C-005 | Human | Colorectum | FAP | 3.87e-07 | -3.19e-01 | -0.0336 |
2140 | EYA3 | A015-C-006 | Human | Colorectum | FAP | 5.85e-17 | -4.94e-01 | -0.0994 |
2140 | EYA3 | A015-C-106 | Human | Colorectum | FAP | 2.59e-11 | -3.96e-01 | -0.0511 |
2140 | EYA3 | A002-C-114 | Human | Colorectum | FAP | 1.25e-18 | -4.66e-01 | -0.1561 |
2140 | EYA3 | A015-C-104 | Human | Colorectum | FAP | 2.82e-26 | -5.10e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:200123410 | Cervix | CC | negative regulation of apoptotic signaling pathway | 56/2311 | 224/18723 | 1.39e-07 | 6.70e-06 | 56 |
GO:009719110 | Cervix | CC | extrinsic apoptotic signaling pathway | 52/2311 | 219/18723 | 2.06e-06 | 6.34e-05 | 52 |
GO:00064708 | Cervix | CC | protein dephosphorylation | 60/2311 | 281/18723 | 1.33e-05 | 2.68e-04 | 60 |
GO:200123610 | Cervix | CC | regulation of extrinsic apoptotic signaling pathway | 37/2311 | 151/18723 | 2.80e-05 | 4.65e-04 | 37 |
GO:00093149 | Cervix | CC | response to radiation | 86/2311 | 456/18723 | 3.50e-05 | 5.63e-04 | 86 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:20010209 | Cervix | CC | regulation of response to DNA damage stimulus | 46/2311 | 219/18723 | 1.92e-04 | 2.23e-03 | 46 |
GO:00102126 | Cervix | CC | response to ionizing radiation | 34/2311 | 148/18723 | 2.23e-04 | 2.53e-03 | 34 |
GO:00510528 | Cervix | CC | regulation of DNA metabolic process | 65/2311 | 359/18723 | 9.25e-04 | 7.84e-03 | 65 |
GO:00163117 | Cervix | CC | dephosphorylation | 73/2311 | 417/18723 | 1.23e-03 | 9.87e-03 | 73 |
GO:200123710 | Cervix | CC | negative regulation of extrinsic apoptotic signaling pathway | 23/2311 | 97/18723 | 1.39e-03 | 1.10e-02 | 23 |
GO:20012332 | Colorectum | MSS | regulation of apoptotic signaling pathway | 116/3467 | 356/18723 | 1.02e-10 | 1.06e-08 | 116 |
GO:00510522 | Colorectum | MSS | regulation of DNA metabolic process | 108/3467 | 359/18723 | 5.86e-08 | 3.10e-06 | 108 |
GO:00510542 | Colorectum | MSS | positive regulation of DNA metabolic process | 69/3467 | 201/18723 | 6.33e-08 | 3.26e-06 | 69 |
GO:20012342 | Colorectum | MSS | negative regulation of apoptotic signaling pathway | 72/3467 | 224/18723 | 6.17e-07 | 2.29e-05 | 72 |
GO:20010202 | Colorectum | MSS | regulation of response to DNA damage stimulus | 64/3467 | 219/18723 | 7.20e-05 | 1.21e-03 | 64 |
GO:00971912 | Colorectum | MSS | extrinsic apoptotic signaling pathway | 63/3467 | 219/18723 | 1.34e-04 | 2.03e-03 | 63 |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:20010221 | Colorectum | MSS | positive regulation of response to DNA damage stimulus | 33/3467 | 105/18723 | 9.83e-04 | 9.86e-03 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EYA3 | SNV | Missense_Mutation | c.316N>A | p.Ala106Thr | p.A106T | Q99504 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EYA3 | SNV | Missense_Mutation | c.1289N>C | p.Lys430Thr | p.K430T | Q99504 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
EYA3 | SNV | Missense_Mutation | novel | c.1634C>T | p.Ala545Val | p.A545V | Q99504 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
EYA3 | SNV | Missense_Mutation | c.910N>T | p.Arg304Trp | p.R304W | Q99504 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
EYA3 | SNV | Missense_Mutation | novel | c.185G>A | p.Arg62His | p.R62H | Q99504 | protein_coding | tolerated(0.05) | possibly_damaging(0.585) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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