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Gene: EXTL2 |
Gene summary for EXTL2 |
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Gene information | Species | Human | Gene symbol | EXTL2 | Gene ID | 2135 |
Gene name | exostosin like glycosyltransferase 2 | |
Gene Alias | EXTR2 | |
Cytomap | 1p21.2 | |
Gene Type | protein-coding | GO ID | GO:0006029 | UniProtAcc | Q9UBQ6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2135 | EXTL2 | LZE7T | Human | Esophagus | ESCC | 1.47e-05 | 2.93e-01 | 0.0667 |
2135 | EXTL2 | P1T-E | Human | Esophagus | ESCC | 2.86e-04 | 1.99e-01 | 0.0875 |
2135 | EXTL2 | P2T-E | Human | Esophagus | ESCC | 7.37e-16 | 3.47e-01 | 0.1177 |
2135 | EXTL2 | P4T-E | Human | Esophagus | ESCC | 8.39e-09 | 2.50e-01 | 0.1323 |
2135 | EXTL2 | P5T-E | Human | Esophagus | ESCC | 1.77e-06 | 7.84e-02 | 0.1327 |
2135 | EXTL2 | P8T-E | Human | Esophagus | ESCC | 3.28e-16 | 2.56e-01 | 0.0889 |
2135 | EXTL2 | P9T-E | Human | Esophagus | ESCC | 2.32e-08 | 1.34e-01 | 0.1131 |
2135 | EXTL2 | P10T-E | Human | Esophagus | ESCC | 3.47e-36 | 6.14e-01 | 0.116 |
2135 | EXTL2 | P11T-E | Human | Esophagus | ESCC | 6.28e-08 | 3.21e-01 | 0.1426 |
2135 | EXTL2 | P12T-E | Human | Esophagus | ESCC | 2.44e-24 | 4.60e-01 | 0.1122 |
2135 | EXTL2 | P15T-E | Human | Esophagus | ESCC | 2.12e-03 | 1.22e-01 | 0.1149 |
2135 | EXTL2 | P16T-E | Human | Esophagus | ESCC | 1.99e-20 | 2.34e-01 | 0.1153 |
2135 | EXTL2 | P20T-E | Human | Esophagus | ESCC | 4.44e-13 | 2.43e-01 | 0.1124 |
2135 | EXTL2 | P21T-E | Human | Esophagus | ESCC | 7.43e-12 | 1.19e-01 | 0.1617 |
2135 | EXTL2 | P22T-E | Human | Esophagus | ESCC | 4.69e-09 | 1.07e-01 | 0.1236 |
2135 | EXTL2 | P23T-E | Human | Esophagus | ESCC | 3.21e-12 | 2.82e-01 | 0.108 |
2135 | EXTL2 | P24T-E | Human | Esophagus | ESCC | 3.33e-08 | 1.31e-01 | 0.1287 |
2135 | EXTL2 | P26T-E | Human | Esophagus | ESCC | 1.53e-23 | 2.57e-01 | 0.1276 |
2135 | EXTL2 | P27T-E | Human | Esophagus | ESCC | 3.34e-17 | 1.74e-01 | 0.1055 |
2135 | EXTL2 | P28T-E | Human | Esophagus | ESCC | 2.15e-07 | 1.29e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00092256 | Esophagus | ESCC | nucleotide-sugar metabolic process | 29/8552 | 36/18723 | 1.91e-05 | 1.67e-04 | 29 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:0006029 | Esophagus | ESCC | proteoglycan metabolic process | 48/8552 | 79/18723 | 4.93e-03 | 1.89e-02 | 48 |
GO:0030166 | Esophagus | ESCC | proteoglycan biosynthetic process | 35/8552 | 56/18723 | 8.30e-03 | 2.94e-02 | 35 |
GO:0030201 | Esophagus | ESCC | heparan sulfate proteoglycan metabolic process | 21/8552 | 31/18723 | 1.10e-02 | 3.70e-02 | 21 |
GO:00092255 | Oral cavity | OSCC | nucleotide-sugar metabolic process | 26/7305 | 36/18723 | 5.44e-05 | 4.51e-04 | 26 |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
GO:00091011 | Oral cavity | OSCC | glycoprotein biosynthetic process | 151/7305 | 317/18723 | 1.01e-03 | 5.26e-03 | 151 |
GO:00064864 | Oral cavity | OSCC | protein glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:00434134 | Oral cavity | OSCC | macromolecule glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:00700853 | Oral cavity | OSCC | glycosylation | 117/7305 | 240/18723 | 1.29e-03 | 6.42e-03 | 117 |
GO:0006040 | Oral cavity | OSCC | amino sugar metabolic process | 24/7305 | 42/18723 | 1.30e-02 | 4.34e-02 | 24 |
GO:00092257 | Thyroid | PTC | nucleotide-sugar metabolic process | 23/5968 | 36/18723 | 7.78e-05 | 6.66e-04 | 23 |
GO:00064866 | Thyroid | PTC | protein glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
GO:00434136 | Thyroid | PTC | macromolecule glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
GO:00700855 | Thyroid | PTC | glycosylation | 96/5968 | 240/18723 | 4.57e-03 | 2.15e-02 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EXTL2 | SNV | Missense_Mutation | novel | c.835N>T | p.Gly279Cys | p.G279C | Q9UBQ6 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-CV-A6K1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EXTL2 | insertion | Nonsense_Mutation | novel | c.913_914insCTTAAAAAAATAC | p.Asp305AlafsTer2 | p.D305Afs*2 | Q9UBQ6 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
EXTL2 | SNV | Missense_Mutation | c.638N>A | p.Ile213Asn | p.I213N | Q9UBQ6 | protein_coding | deleterious(0.01) | possibly_damaging(0.82) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
EXTL2 | SNV | Missense_Mutation | c.42N>T | p.Met14Ile | p.M14I | Q9UBQ6 | protein_coding | tolerated_low_confidence(0.23) | benign(0.014) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
EXTL2 | insertion | Nonsense_Mutation | novel | c.915_916insGTTGCTTAAAAAAATACAT | p.Ser306ValfsTer3 | p.S306Vfs*3 | Q9UBQ6 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
EXTL2 | insertion | Nonsense_Mutation | novel | c.915_916insGTTGCTTAAAAAAATACAT | p.Ser306ValfsTer3 | p.S306Vfs*3 | Q9UBQ6 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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