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Gene: ERICH5 |
Gene summary for ERICH5 |
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Gene information | Species | Human | Gene symbol | ERICH5 | Gene ID | 203111 |
Gene name | glutamate rich 5 | |
Gene Alias | C8orf47 | |
Cytomap | 8q22.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6P6B1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
203111 | ERICH5 | S43 | Human | Liver | Cirrhotic | 1.31e-08 | -2.06e-01 | -0.0187 |
203111 | ERICH5 | HCC1_Meng | Human | Liver | HCC | 7.05e-70 | 1.01e-02 | 0.0246 |
203111 | ERICH5 | HCC2_Meng | Human | Liver | HCC | 6.25e-23 | -3.73e-02 | 0.0107 |
203111 | ERICH5 | cirrhotic1 | Human | Liver | Cirrhotic | 2.14e-16 | 3.33e-01 | 0.0202 |
203111 | ERICH5 | cirrhotic2 | Human | Liver | Cirrhotic | 3.40e-13 | 2.00e-01 | 0.0201 |
203111 | ERICH5 | cirrhotic3 | Human | Liver | Cirrhotic | 3.45e-09 | 9.99e-02 | 0.0215 |
203111 | ERICH5 | HCC2 | Human | Liver | HCC | 2.06e-03 | 1.82e+00 | 0.5341 |
203111 | ERICH5 | Pt13.a | Human | Liver | HCC | 2.20e-10 | -2.69e-01 | 0.021 |
203111 | ERICH5 | Pt13.b | Human | Liver | HCC | 2.63e-03 | -2.69e-01 | 0.0251 |
203111 | ERICH5 | Pt14.d | Human | Liver | HCC | 1.01e-10 | -2.69e-01 | 0.0143 |
203111 | ERICH5 | S014 | Human | Liver | HCC | 3.63e-02 | -2.69e-01 | 0.2254 |
203111 | ERICH5 | S016 | Human | Liver | HCC | 4.83e-02 | -2.52e-01 | 0.2243 |
203111 | ERICH5 | S027 | Human | Liver | HCC | 4.80e-05 | 8.06e-01 | 0.2446 |
203111 | ERICH5 | S028 | Human | Liver | HCC | 5.32e-26 | 1.25e+00 | 0.2503 |
203111 | ERICH5 | S029 | Human | Liver | HCC | 8.15e-25 | 1.39e+00 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERICH5 | SNV | Missense_Mutation | c.698N>C | p.Gly233Ala | p.G233A | Q6P6B1 | protein_coding | tolerated(0.08) | benign(0.164) | TCGA-D7-6528-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ERICH5 | SNV | Missense_Mutation | c.240A>T | p.Gln80His | p.Q80H | Q6P6B1 | protein_coding | tolerated(0.71) | benign(0) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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