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Gene: EPHX1 |
Gene summary for EPHX1 |
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Gene information | Species | Human | Gene symbol | EPHX1 | Gene ID | 2052 |
Gene name | epoxide hydrolase 1 | |
Gene Alias | EPHX | |
Cytomap | 1q42.12 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | P07099 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2052 | EPHX1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.17e-04 | 3.35e-01 | -0.1954 |
2052 | EPHX1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.29e-02 | 1.99e-01 | 0.0674 |
2052 | EPHX1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.49e-10 | 4.55e-01 | 0.3859 |
2052 | EPHX1 | A018-E-020 | Human | Colorectum | FAP | 1.04e-02 | -1.10e-01 | -0.2034 |
2052 | EPHX1 | LZE2T | Human | Esophagus | ESCC | 2.16e-09 | 2.49e+00 | 0.082 |
2052 | EPHX1 | LZE4T | Human | Esophagus | ESCC | 4.96e-23 | 1.36e+00 | 0.0811 |
2052 | EPHX1 | LZE5T | Human | Esophagus | ESCC | 1.03e-10 | 1.57e+00 | 0.0514 |
2052 | EPHX1 | LZE7T | Human | Esophagus | ESCC | 5.40e-06 | 9.81e-01 | 0.0667 |
2052 | EPHX1 | LZE8T | Human | Esophagus | ESCC | 3.55e-16 | 1.05e+00 | 0.067 |
2052 | EPHX1 | LZE20T | Human | Esophagus | ESCC | 2.86e-09 | 1.00e+00 | 0.0662 |
2052 | EPHX1 | LZE22D1 | Human | Esophagus | HGIN | 1.34e-03 | 9.78e-01 | 0.0595 |
2052 | EPHX1 | LZE22T | Human | Esophagus | ESCC | 7.72e-13 | 2.17e+00 | 0.068 |
2052 | EPHX1 | LZE24T | Human | Esophagus | ESCC | 3.67e-23 | 1.05e+00 | 0.0596 |
2052 | EPHX1 | LZE21T | Human | Esophagus | ESCC | 3.36e-05 | 1.10e+00 | 0.0655 |
2052 | EPHX1 | P1T-E | Human | Esophagus | ESCC | 5.60e-15 | 1.44e+00 | 0.0875 |
2052 | EPHX1 | P2T-E | Human | Esophagus | ESCC | 7.38e-28 | 7.53e-01 | 0.1177 |
2052 | EPHX1 | P4T-E | Human | Esophagus | ESCC | 9.77e-30 | 9.73e-01 | 0.1323 |
2052 | EPHX1 | P5T-E | Human | Esophagus | ESCC | 1.05e-13 | 5.21e-01 | 0.1327 |
2052 | EPHX1 | P8T-E | Human | Esophagus | ESCC | 8.43e-81 | 1.89e+00 | 0.0889 |
2052 | EPHX1 | P9T-E | Human | Esophagus | ESCC | 4.72e-50 | 1.99e+00 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0018904 | Colorectum | AD | ether metabolic process | 14/3918 | 27/18723 | 3.72e-04 | 4.29e-03 | 14 |
GO:00194392 | Colorectum | MSS | aromatic compound catabolic process | 140/3467 | 467/18723 | 8.56e-10 | 6.85e-08 | 140 |
GO:00096362 | Colorectum | MSS | response to toxic substance | 73/3467 | 262/18723 | 1.26e-04 | 1.94e-03 | 73 |
GO:00066312 | Colorectum | MSS | fatty acid metabolic process | 95/3467 | 390/18723 | 2.20e-03 | 1.84e-02 | 95 |
GO:00094101 | Colorectum | MSS | response to xenobiotic stimulus | 110/3467 | 462/18723 | 2.36e-03 | 1.92e-02 | 110 |
GO:00194394 | Colorectum | FAP | aromatic compound catabolic process | 100/2622 | 467/18723 | 6.75e-06 | 2.08e-04 | 100 |
GO:00066313 | Colorectum | FAP | fatty acid metabolic process | 81/2622 | 390/18723 | 1.43e-04 | 2.24e-03 | 81 |
GO:00094102 | Colorectum | FAP | response to xenobiotic stimulus | 87/2622 | 462/18723 | 2.15e-03 | 1.77e-02 | 87 |
GO:00189042 | Colorectum | FAP | ether metabolic process | 10/2622 | 27/18723 | 2.46e-03 | 1.95e-02 | 10 |
GO:00096363 | Colorectum | FAP | response to toxic substance | 53/2622 | 262/18723 | 3.35e-03 | 2.46e-02 | 53 |
GO:001943917 | Esophagus | HGIN | aromatic compound catabolic process | 105/2587 | 467/18723 | 1.89e-07 | 9.31e-06 | 105 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
GO:00066316 | Liver | NAFLD | fatty acid metabolic process | 92/1882 | 390/18723 | 3.38e-15 | 3.29e-12 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05208 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa052081 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa052084 | Colorectum | MSS | Chemical carcinogenesis - reactive oxygen species | 118/1875 | 223/8465 | 2.71e-24 | 4.54e-22 | 2.78e-22 | 118 |
hsa052085 | Colorectum | MSS | Chemical carcinogenesis - reactive oxygen species | 118/1875 | 223/8465 | 2.71e-24 | 4.54e-22 | 2.78e-22 | 118 |
hsa052088 | Colorectum | FAP | Chemical carcinogenesis - reactive oxygen species | 78/1404 | 223/8465 | 1.08e-11 | 1.80e-09 | 1.09e-09 | 78 |
hsa052089 | Colorectum | FAP | Chemical carcinogenesis - reactive oxygen species | 78/1404 | 223/8465 | 1.08e-11 | 1.80e-09 | 1.09e-09 | 78 |
hsa0520839 | Esophagus | HGIN | Chemical carcinogenesis - reactive oxygen species | 92/1383 | 223/8465 | 2.41e-19 | 9.83e-18 | 7.80e-18 | 92 |
hsa05208115 | Esophagus | HGIN | Chemical carcinogenesis - reactive oxygen species | 92/1383 | 223/8465 | 2.41e-19 | 9.83e-18 | 7.80e-18 | 92 |
hsa05208211 | Esophagus | ESCC | Chemical carcinogenesis - reactive oxygen species | 168/4205 | 223/8465 | 1.83e-15 | 6.81e-14 | 3.49e-14 | 168 |
hsa05208310 | Esophagus | ESCC | Chemical carcinogenesis - reactive oxygen species | 168/4205 | 223/8465 | 1.83e-15 | 6.81e-14 | 3.49e-14 | 168 |
hsa0520814 | Liver | NAFLD | Chemical carcinogenesis - reactive oxygen species | 44/1043 | 223/8465 | 9.22e-04 | 1.31e-02 | 1.06e-02 | 44 |
hsa049762 | Liver | NAFLD | Bile secretion | 20/1043 | 89/8465 | 5.08e-03 | 4.43e-02 | 3.57e-02 | 20 |
hsa0520815 | Liver | NAFLD | Chemical carcinogenesis - reactive oxygen species | 44/1043 | 223/8465 | 9.22e-04 | 1.31e-02 | 1.06e-02 | 44 |
hsa0497611 | Liver | NAFLD | Bile secretion | 20/1043 | 89/8465 | 5.08e-03 | 4.43e-02 | 3.57e-02 | 20 |
hsa0520822 | Liver | Cirrhotic | Chemical carcinogenesis - reactive oxygen species | 121/2530 | 223/8465 | 1.35e-14 | 4.08e-13 | 2.52e-13 | 121 |
hsa0520832 | Liver | Cirrhotic | Chemical carcinogenesis - reactive oxygen species | 121/2530 | 223/8465 | 1.35e-14 | 4.08e-13 | 2.52e-13 | 121 |
hsa0520842 | Liver | HCC | Chemical carcinogenesis - reactive oxygen species | 167/4020 | 223/8465 | 2.85e-17 | 1.91e-15 | 1.06e-15 | 167 |
hsa0520852 | Liver | HCC | Chemical carcinogenesis - reactive oxygen species | 167/4020 | 223/8465 | 2.85e-17 | 1.91e-15 | 1.06e-15 | 167 |
hsa0520862 | Liver | Cyst | Chemical carcinogenesis - reactive oxygen species | 40/339 | 223/8465 | 4.80e-16 | 3.45e-14 | 2.85e-14 | 40 |
hsa0520872 | Liver | Cyst | Chemical carcinogenesis - reactive oxygen species | 40/339 | 223/8465 | 4.80e-16 | 3.45e-14 | 2.85e-14 | 40 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EPHX1 | insertion | Frame_Shift_Ins | novel | c.189dupA | p.His64ThrfsTer6 | p.H64Tfs*6 | P07099 | protein_coding | TCGA-78-7146-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
EPHX1 | deletion | In_Frame_Del | novel | c.145_150delNNNNNN | p.Arg49_Pro50del | p.R49_P50del | P07099 | protein_coding | TCGA-78-7162-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
EPHX1 | SNV | Missense_Mutation | c.1024N>A | p.Asp342Asn | p.D342N | P07099 | protein_coding | deleterious(0.02) | possibly_damaging(0.558) | TCGA-D6-8569-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EPHX1 | SNV | Missense_Mutation | c.13N>G | p.Ile5Val | p.I5V | P07099 | protein_coding | tolerated(0.52) | benign(0.014) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |
EPHX1 | SNV | Missense_Mutation | rs45449793 | c.853N>A | p.Val285Ile | p.V285I | P07099 | protein_coding | deleterious(0.05) | benign(0.067) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
EPHX1 | SNV | Missense_Mutation | c.1023N>T | p.Glu341Asp | p.E341D | P07099 | protein_coding | tolerated(0.37) | benign(0.05) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EPHX1 | SNV | Missense_Mutation | rs755904769 | c.1166N>A | p.Arg389Gln | p.R389Q | P07099 | protein_coding | tolerated(0.22) | benign(0.233) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
EPHX1 | SNV | Missense_Mutation | novel | c.413G>A | p.Gly138Asp | p.G138D | P07099 | protein_coding | tolerated(0.13) | possibly_damaging(0.905) | TCGA-MX-A663-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EPHX1 | SNV | Missense_Mutation | novel | c.320N>C | p.Val107Ala | p.V107A | P07099 | protein_coding | tolerated(0.22) | possibly_damaging(0.497) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EPHX1 | deletion | In_Frame_Del | novel | c.462_473delNNNNNNNNNNNN | p.Tyr155_Tyr158del | p.Y155_Y158del | P07099 | protein_coding | TCGA-BR-6563-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | doxorubicin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2052 | EPHX1 | ENZYME, DRUGGABLE GENOME | docetaxel | DOCETAXEL | 20157331 | |
2052 | EPHX1 | ENZYME, DRUGGABLE GENOME | phenytoin | PHENYTOIN | 19952982 | |
2052 | EPHX1 | ENZYME, DRUGGABLE GENOME | phenprocoumon | PHENPROCOUMON | 21057703 | |
2052 | EPHX1 | ENZYME, DRUGGABLE GENOME | AR9281 | AR9281 | ||
2052 | EPHX1 | ENZYME, DRUGGABLE GENOME | cisplatin | CISPLATIN | 24533712 | |
2052 | EPHX1 | ENZYME, DRUGGABLE GENOME | ANTICONVULSANT | 10554101 | ||
2052 | EPHX1 | ENZYME, DRUGGABLE GENOME | cyclophosphamide | CYCLOPHOSPHAMIDE | 24533712 | |
2052 | EPHX1 | ENZYME, DRUGGABLE GENOME | carbamazepine | CARBAMAZEPINE | 15692831,22188362,26314341,25495409,19620853 |
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