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Gene: ENAM |
Gene summary for ENAM |
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Gene information | Species | Human | Gene symbol | ENAM | Gene ID | 10117 |
Gene name | enamelin | |
Gene Alias | ADAI | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0002065 | UniProtAcc | Q9NRM1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10117 | ENAM | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 3.71e-02 | 5.24e-01 | 0.159 |
10117 | ENAM | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 2.46e-15 | 1.45e+00 | 0.1479 |
10117 | ENAM | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 3.78e-07 | 9.10e-01 | 0.1531 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENAM | SNV | Missense_Mutation | c.3188C>T | p.Ala1063Val | p.A1063V | Q9NRM1 | protein_coding | deleterious(0.02) | possibly_damaging(0.897) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
ENAM | SNV | Missense_Mutation | novel | c.2968C>A | p.Leu990Ile | p.L990I | Q9NRM1 | protein_coding | tolerated(0.12) | possibly_damaging(0.465) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ENAM | insertion | Frame_Shift_Ins | novel | c.136dupC | p.Arg46ProfsTer6 | p.R46Pfs*6 | Q9NRM1 | protein_coding | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | ||
ENAM | insertion | Frame_Shift_Ins | novel | c.3100_3101insA | p.Ser1035LysfsTer7 | p.S1035Kfs*7 | Q9NRM1 | protein_coding | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ENAM | insertion | Frame_Shift_Ins | rs752102959 | c.582_583insG | p.Asn197GlufsTer25 | p.N197Efs*25 | Q9NRM1 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ENAM | insertion | Frame_Shift_Ins | novel | c.2138dupA | p.Asp713GlufsTer6 | p.D713Efs*6 | Q9NRM1 | protein_coding | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ENAM | insertion | Frame_Shift_Ins | novel | c.3358_3359insA | p.Pro1120HisfsTer3 | p.P1120Hfs*3 | Q9NRM1 | protein_coding | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ENAM | SNV | Missense_Mutation | rs139404568 | c.3263C>T | p.Thr1088Met | p.T1088M | Q9NRM1 | protein_coding | tolerated(1) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENAM | SNV | Missense_Mutation | c.631C>T | p.Arg211Cys | p.R211C | Q9NRM1 | protein_coding | deleterious(0) | benign(0.067) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ENAM | SNV | Missense_Mutation | novel | c.978A>T | p.Arg326Ser | p.R326S | Q9NRM1 | protein_coding | tolerated(0.05) | possibly_damaging(0.9) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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