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Gene: ELP3 |
Gene summary for ELP3 |
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Gene information | Species | Human | Gene symbol | ELP3 | Gene ID | 55140 |
Gene name | elongator acetyltransferase complex subunit 3 | |
Gene Alias | KAT9 | |
Cytomap | 8p21.1 | |
Gene Type | protein-coding | GO ID | GO:0001764 | UniProtAcc | B4DKA4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55140 | ELP3 | AEH-subject3 | Human | Endometrium | AEH | 1.51e-04 | 3.06e-01 | -0.2576 |
55140 | ELP3 | AEH-subject4 | Human | Endometrium | AEH | 1.54e-04 | 3.45e-01 | -0.2657 |
55140 | ELP3 | AEH-subject5 | Human | Endometrium | AEH | 4.65e-06 | 4.30e-01 | -0.2953 |
55140 | ELP3 | EEC-subject1 | Human | Endometrium | EEC | 2.37e-02 | 2.64e-01 | -0.2682 |
55140 | ELP3 | EEC-subject4 | Human | Endometrium | EEC | 1.19e-23 | 7.25e-01 | -0.2571 |
55140 | ELP3 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.03e-07 | 8.50e-03 | -0.1869 |
55140 | ELP3 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.78e-05 | 1.56e-03 | -0.1875 |
55140 | ELP3 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 4.39e-11 | 2.14e-01 | -0.1883 |
55140 | ELP3 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.37e-08 | 3.65e-01 | -0.1934 |
55140 | ELP3 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.09e-08 | 1.46e-02 | -0.1917 |
55140 | ELP3 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.23e-11 | 2.45e-02 | -0.1916 |
55140 | ELP3 | LZE4T | Human | Esophagus | ESCC | 1.71e-05 | 1.04e-01 | 0.0811 |
55140 | ELP3 | LZE8T | Human | Esophagus | ESCC | 1.81e-03 | 6.19e-02 | 0.067 |
55140 | ELP3 | LZE20T | Human | Esophagus | ESCC | 5.22e-04 | 9.43e-02 | 0.0662 |
55140 | ELP3 | LZE24T | Human | Esophagus | ESCC | 2.04e-04 | 5.12e-02 | 0.0596 |
55140 | ELP3 | LZE21T | Human | Esophagus | ESCC | 2.34e-02 | 1.10e-01 | 0.0655 |
55140 | ELP3 | P2T-E | Human | Esophagus | ESCC | 1.63e-19 | 2.00e-01 | 0.1177 |
55140 | ELP3 | P4T-E | Human | Esophagus | ESCC | 8.96e-18 | 2.56e-01 | 0.1323 |
55140 | ELP3 | P5T-E | Human | Esophagus | ESCC | 5.35e-12 | 7.24e-02 | 0.1327 |
55140 | ELP3 | P8T-E | Human | Esophagus | ESCC | 6.07e-14 | 1.74e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00017642 | Endometrium | AEH | neuron migration | 31/2100 | 156/18723 | 1.08e-03 | 9.46e-03 | 31 |
GO:00344707 | Endometrium | AEH | ncRNA processing | 62/2100 | 395/18723 | 3.93e-03 | 2.65e-02 | 62 |
GO:00017641 | Endometrium | EEC | neuron migration | 33/2168 | 156/18723 | 4.17e-04 | 4.38e-03 | 33 |
GO:003447012 | Endometrium | EEC | ncRNA processing | 63/2168 | 395/18723 | 5.20e-03 | 3.26e-02 | 63 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:00080332 | Oral cavity | OSCC | tRNA processing | 78/7305 | 127/18723 | 2.56e-07 | 4.00e-06 | 78 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
GO:00094511 | Oral cavity | OSCC | RNA modification | 95/7305 | 167/18723 | 2.05e-06 | 2.62e-05 | 95 |
GO:00064001 | Oral cavity | OSCC | tRNA modification | 53/7305 | 90/18723 | 1.04e-04 | 7.70e-04 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELP3 | SNV | Missense_Mutation | novel | c.355G>A | p.Asp119Asn | p.D119N | Q9H9T3 | protein_coding | tolerated(0.07) | probably_damaging(0.99) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ELP3 | SNV | Missense_Mutation | novel | c.744N>C | p.Gln248His | p.Q248H | Q9H9T3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ELP3 | SNV | Missense_Mutation | novel | c.457G>C | p.Glu153Gln | p.E153Q | Q9H9T3 | protein_coding | tolerated(0.09) | benign(0.127) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
ELP3 | SNV | Missense_Mutation | c.1563A>G | p.Ile521Met | p.I521M | Q9H9T3 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ELP3 | SNV | Missense_Mutation | c.370A>G | p.Thr124Ala | p.T124A | Q9H9T3 | protein_coding | tolerated(0.11) | possibly_damaging(0.868) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ELP3 | SNV | Missense_Mutation | rs754899290 | c.109G>A | p.Asp37Asn | p.D37N | Q9H9T3 | protein_coding | tolerated(1) | benign(0) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ELP3 | SNV | Missense_Mutation | novel | c.175N>A | p.Asp59Asn | p.D59N | Q9H9T3 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
ELP3 | SNV | Missense_Mutation | rs140697794 | c.406N>G | p.Arg136Gly | p.R136G | Q9H9T3 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ELP3 | insertion | Frame_Shift_Ins | novel | c.436_439dupCTAC | p.Gln147ProfsTer16 | p.Q147Pfs*16 | Q9H9T3 | protein_coding | TCGA-BR-7197-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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