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Gene: ELMSAN1 |
Gene summary for ELMSAN1 |
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Gene information | Species | Human | Gene symbol | ELMSAN1 | Gene ID | 91748 |
Gene name | mitotic deacetylase associated SANT domain protein | |
Gene Alias | C14orf117 | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R689 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91748 | ELMSAN1 | LZE4T | Human | Esophagus | ESCC | 2.77e-09 | 3.33e-01 | 0.0811 |
91748 | ELMSAN1 | LZE7T | Human | Esophagus | ESCC | 5.13e-03 | 1.16e-01 | 0.0667 |
91748 | ELMSAN1 | LZE8T | Human | Esophagus | ESCC | 2.14e-03 | 4.02e-02 | 0.067 |
91748 | ELMSAN1 | LZE20T | Human | Esophagus | ESCC | 4.38e-02 | 2.06e-01 | 0.0662 |
91748 | ELMSAN1 | LZE24T | Human | Esophagus | ESCC | 2.76e-09 | 2.99e-01 | 0.0596 |
91748 | ELMSAN1 | LZE21T | Human | Esophagus | ESCC | 1.40e-02 | 2.50e-01 | 0.0655 |
91748 | ELMSAN1 | P1T-E | Human | Esophagus | ESCC | 3.93e-05 | 3.48e-01 | 0.0875 |
91748 | ELMSAN1 | P2T-E | Human | Esophagus | ESCC | 1.16e-16 | 4.26e-01 | 0.1177 |
91748 | ELMSAN1 | P4T-E | Human | Esophagus | ESCC | 1.03e-14 | 3.27e-01 | 0.1323 |
91748 | ELMSAN1 | P5T-E | Human | Esophagus | ESCC | 1.19e-17 | 1.58e-01 | 0.1327 |
91748 | ELMSAN1 | P8T-E | Human | Esophagus | ESCC | 4.16e-17 | 3.52e-01 | 0.0889 |
91748 | ELMSAN1 | P9T-E | Human | Esophagus | ESCC | 8.53e-08 | 1.37e-01 | 0.1131 |
91748 | ELMSAN1 | P10T-E | Human | Esophagus | ESCC | 3.56e-33 | 6.10e-01 | 0.116 |
91748 | ELMSAN1 | P11T-E | Human | Esophagus | ESCC | 1.62e-15 | 7.59e-01 | 0.1426 |
91748 | ELMSAN1 | P12T-E | Human | Esophagus | ESCC | 1.19e-13 | 2.61e-01 | 0.1122 |
91748 | ELMSAN1 | P15T-E | Human | Esophagus | ESCC | 5.57e-25 | 5.71e-01 | 0.1149 |
91748 | ELMSAN1 | P16T-E | Human | Esophagus | ESCC | 3.02e-11 | 1.74e-01 | 0.1153 |
91748 | ELMSAN1 | P17T-E | Human | Esophagus | ESCC | 1.54e-07 | 2.86e-01 | 0.1278 |
91748 | ELMSAN1 | P19T-E | Human | Esophagus | ESCC | 1.59e-04 | 4.82e-01 | 0.1662 |
91748 | ELMSAN1 | P20T-E | Human | Esophagus | ESCC | 7.33e-17 | 3.48e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELMSAN1 | SNV | Missense_Mutation | rs201031364 | c.55N>A | p.Gly19Arg | p.G19R | Q6PJG2 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ELMSAN1 | SNV | Missense_Mutation | novel | c.2992G>A | p.Gly998Ser | p.G998S | Q6PJG2 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ELMSAN1 | SNV | Missense_Mutation | rs757966332 | c.1601N>A | p.Arg534Gln | p.R534Q | Q6PJG2 | protein_coding | deleterious(0.01) | possibly_damaging(0.701) | TCGA-AP-A1DR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ELMSAN1 | SNV | Missense_Mutation | novel | c.1220N>T | p.Ser407Leu | p.S407L | Q6PJG2 | protein_coding | deleterious(0.02) | benign(0.009) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ELMSAN1 | SNV | Missense_Mutation | rs772631943 | c.1361N>T | p.Thr454Met | p.T454M | Q6PJG2 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ELMSAN1 | SNV | Missense_Mutation | c.2860N>C | p.Glu954Gln | p.E954Q | Q6PJG2 | protein_coding | deleterious(0.02) | possibly_damaging(0.515) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
ELMSAN1 | SNV | Missense_Mutation | novel | c.2969N>G | p.Glu990Gly | p.E990G | Q6PJG2 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ELMSAN1 | SNV | Missense_Mutation | novel | c.2611N>C | p.Tyr871His | p.Y871H | Q6PJG2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A1MW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ELMSAN1 | SNV | Missense_Mutation | rs567181899 | c.1712G>A | p.Arg571Gln | p.R571Q | Q6PJG2 | protein_coding | deleterious(0.03) | possibly_damaging(0.548) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ELMSAN1 | SNV | Missense_Mutation | c.1755N>T | p.Glu585Asp | p.E585D | Q6PJG2 | protein_coding | tolerated(0.12) | benign(0) | TCGA-D1-A0ZS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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