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Gene: ELAVL2 |
Gene summary for ELAVL2 |
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Gene information | Species | Human | Gene symbol | ELAVL2 | Gene ID | 1993 |
Gene name | ELAV like RNA binding protein 2 | |
Gene Alias | HEL-N1 | |
Cytomap | 9p21.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q12926 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1993 | ELAVL2 | C04 | Human | Oral cavity | OSCC | 1.01e-09 | 5.28e-01 | 0.2633 |
1993 | ELAVL2 | C21 | Human | Oral cavity | OSCC | 1.81e-15 | 5.17e-01 | 0.2678 |
1993 | ELAVL2 | C30 | Human | Oral cavity | OSCC | 4.10e-19 | 7.60e-01 | 0.3055 |
1993 | ELAVL2 | C06 | Human | Oral cavity | OSCC | 3.82e-02 | 3.97e-01 | 0.2699 |
1993 | ELAVL2 | SYSMH3 | Human | Oral cavity | OSCC | 3.21e-19 | 3.85e-01 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELAVL2 | SNV | Missense_Mutation | novel | c.692N>A | p.Ala231Asp | p.A231D | Q12926 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
ELAVL2 | SNV | Missense_Mutation | novel | c.545N>T | p.Ala182Val | p.A182V | Q12926 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ELAVL2 | SNV | Missense_Mutation | c.817G>A | p.Gly273Arg | p.G273R | Q12926 | protein_coding | deleterious(0.03) | benign(0.187) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ELAVL2 | SNV | Missense_Mutation | c.101N>A | p.Thr34Lys | p.T34K | Q12926 | protein_coding | tolerated(0.53) | benign(0.003) | TCGA-33-4586-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
ELAVL2 | SNV | Missense_Mutation | novel | c.867N>C | p.Glu289Asp | p.E289D | Q12926 | protein_coding | tolerated(0.23) | benign(0.317) | TCGA-33-AASD-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ELAVL2 | SNV | Missense_Mutation | rs780367763 | c.959N>T | p.Gly320Val | p.G320V | Q12926 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-34-8455-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ELAVL2 | SNV | Missense_Mutation | c.706N>G | p.Arg236Gly | p.R236G | Q12926 | protein_coding | tolerated(0.07) | benign(0.411) | TCGA-46-3767-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ELAVL2 | SNV | Missense_Mutation | novel | c.692N>T | p.Ala231Val | p.A231V | Q12926 | protein_coding | tolerated(0.12) | benign(0.017) | TCGA-77-8009-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ELAVL2 | SNV | Missense_Mutation | novel | c.808G>C | p.Gly270Arg | p.G270R | Q12926 | protein_coding | deleterious(0.02) | possibly_damaging(0.522) | TCGA-85-8353-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ELAVL2 | SNV | Missense_Mutation | c.496A>T | p.Arg166Trp | p.R166W | Q12926 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-92-8064-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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