Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DPP8_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DPP8_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DPP8_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DPP8_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DPP8 | SNV | Missense_Mutation | novel | c.1451N>A | p.Ser484Tyr | p.S484Y | Q6V1X1 | protein_coding | deleterious(0) | possibly_damaging(0.835) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | novel | c.773N>G | p.Asn258Ser | p.N258S | Q6V1X1 | protein_coding | tolerated(0.74) | benign(0.001) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | novel | c.2185N>A | p.Asp729Asn | p.D729N | Q6V1X1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | novel | c.901N>C | p.Ile301Leu | p.I301L | Q6V1X1 | protein_coding | tolerated(0.16) | benign(0.253) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | | c.904C>A | p.Leu302Ile | p.L302I | Q6V1X1 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | | c.449N>A | p.Arg150Gln | p.R150Q | Q6V1X1 | protein_coding | deleterious(0) | possibly_damaging(0.571) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | | c.2036N>C | p.Asn679Thr | p.N679T | Q6V1X1 | protein_coding | deleterious(0) | possibly_damaging(0.821) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | | c.493N>A | p.Gly165Arg | p.G165R | Q6V1X1 | protein_coding | deleterious(0.01) | benign(0.387) | TCGA-D1-A17M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | | c.493N>A | p.Gly165Arg | p.G165R | Q6V1X1 | protein_coding | deleterious(0.01) | benign(0.387) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DPP8 | SNV | Missense_Mutation | novel | c.1776G>T | p.Lys592Asn | p.K592N | Q6V1X1 | protein_coding | tolerated(0.4) | benign(0.038) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 178103150 | | |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 252166751 | | |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | | Thiomorpholine derivative 1 | | |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | | Thiomorpholine derivative 2 | | |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 252166752 | | |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 363894200 | TENELIGLIPTIN | |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | | Talabostat | TALABOSTAT | |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 363894187 | | |
54878 | DPP8 | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 363894186 | TALABOSTAT | |