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Gene: DMXL1 |
Gene summary for DMXL1 |
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Gene information | Species | Human | Gene symbol | DMXL1 | Gene ID | 1657 |
Gene name | Dmx like 1 | |
Gene Alias | DMXL1 | |
Cytomap | 5q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | B2RWN7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1657 | DMXL1 | CCI_2 | Human | Cervix | CC | 5.81e-10 | 1.16e+00 | 0.5249 |
1657 | DMXL1 | CCI_3 | Human | Cervix | CC | 6.54e-08 | 7.22e-01 | 0.516 |
1657 | DMXL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.24e-21 | -6.83e-01 | 0.0155 |
1657 | DMXL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.69e-03 | -4.29e-01 | -0.1808 |
1657 | DMXL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.16e-06 | -5.17e-01 | -0.1207 |
1657 | DMXL1 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.15e-03 | -4.52e-01 | -0.1526 |
1657 | DMXL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.31e-04 | -4.06e-01 | -0.1464 |
1657 | DMXL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.73e-02 | -4.05e-01 | -0.1001 |
1657 | DMXL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.08e-05 | -4.59e-01 | -0.059 |
1657 | DMXL1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.26e-03 | -5.46e-01 | -0.2061 |
1657 | DMXL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.63e-11 | -5.33e-01 | 0.096 |
1657 | DMXL1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.04e-02 | -5.65e-01 | -0.0177 |
1657 | DMXL1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.55e-05 | -4.59e-01 | 0.0338 |
1657 | DMXL1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.90e-07 | -5.09e-01 | 0.0674 |
1657 | DMXL1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.87e-04 | -4.08e-01 | 0.0588 |
1657 | DMXL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.32e-16 | -5.67e-01 | 0.294 |
1657 | DMXL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.08e-02 | -3.57e-01 | 0.3859 |
1657 | DMXL1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.14e-05 | -5.38e-01 | 0.2585 |
1657 | DMXL1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.86e-05 | -4.11e-01 | 0.3005 |
1657 | DMXL1 | F007 | Human | Colorectum | FAP | 1.24e-06 | -4.67e-01 | 0.1176 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
GO:0030641 | Colorectum | AD | regulation of cellular pH | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
GO:0051453 | Colorectum | AD | regulation of intracellular pH | 26/3918 | 75/18723 | 4.04e-03 | 2.82e-02 | 26 |
GO:0006885 | Colorectum | AD | regulation of pH | 30/3918 | 91/18723 | 4.95e-03 | 3.32e-02 | 30 |
GO:0055067 | Colorectum | AD | monovalent inorganic cation homeostasis | 45/3918 | 151/18723 | 6.19e-03 | 3.88e-02 | 45 |
GO:00300041 | Colorectum | SER | cellular monovalent inorganic cation homeostasis | 31/2897 | 103/18723 | 1.31e-04 | 2.66e-03 | 31 |
GO:00306411 | Colorectum | SER | regulation of cellular pH | 24/2897 | 81/18723 | 9.20e-04 | 1.11e-02 | 24 |
GO:00550671 | Colorectum | SER | monovalent inorganic cation homeostasis | 37/2897 | 151/18723 | 2.48e-03 | 2.33e-02 | 37 |
GO:00514531 | Colorectum | SER | regulation of intracellular pH | 21/2897 | 75/18723 | 3.97e-03 | 3.26e-02 | 21 |
GO:00068851 | Colorectum | SER | regulation of pH | 24/2897 | 91/18723 | 5.03e-03 | 3.88e-02 | 24 |
GO:00300042 | Colorectum | MSS | cellular monovalent inorganic cation homeostasis | 31/3467 | 103/18723 | 2.94e-03 | 2.27e-02 | 31 |
GO:00306412 | Colorectum | MSS | regulation of cellular pH | 25/3467 | 81/18723 | 4.97e-03 | 3.46e-02 | 25 |
GO:00300043 | Colorectum | FAP | cellular monovalent inorganic cation homeostasis | 28/2622 | 103/18723 | 3.23e-04 | 4.15e-03 | 28 |
GO:00514532 | Colorectum | FAP | regulation of intracellular pH | 22/2622 | 75/18723 | 4.38e-04 | 5.21e-03 | 22 |
GO:00306413 | Colorectum | FAP | regulation of cellular pH | 22/2622 | 81/18723 | 1.37e-03 | 1.24e-02 | 22 |
GO:00550672 | Colorectum | FAP | monovalent inorganic cation homeostasis | 35/2622 | 151/18723 | 1.58e-03 | 1.40e-02 | 35 |
GO:00068852 | Colorectum | FAP | regulation of pH | 23/2622 | 91/18723 | 3.00e-03 | 2.27e-02 | 23 |
GO:00514533 | Colorectum | CRC | regulation of intracellular pH | 17/2078 | 75/18723 | 3.04e-03 | 2.71e-02 | 17 |
GO:00300044 | Colorectum | CRC | cellular monovalent inorganic cation homeostasis | 21/2078 | 103/18723 | 4.15e-03 | 3.40e-02 | 21 |
GO:00306414 | Colorectum | CRC | regulation of cellular pH | 17/2078 | 81/18723 | 6.93e-03 | 4.85e-02 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa0414211 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMXL1 | SNV | Missense_Mutation | c.7121N>T | p.Ser2374Leu | p.S2374L | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
DMXL1 | SNV | Missense_Mutation | rs752622065 | c.4292N>T | p.Thr1431Met | p.T1431M | protein_coding | tolerated(0.09) | benign(0.333) | TCGA-AA-A01V-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DMXL1 | SNV | Missense_Mutation | c.5081N>A | p.Phe1694Tyr | p.F1694Y | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
DMXL1 | SNV | Missense_Mutation | novel | c.8135N>A | p.Gly2712Glu | p.G2712E | protein_coding | tolerated(0.21) | possibly_damaging(0.628) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DMXL1 | SNV | Missense_Mutation | c.2495T>A | p.Val832Asp | p.V832D | protein_coding | deleterious(0) | possibly_damaging(0.849) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
DMXL1 | SNV | Missense_Mutation | c.4124C>T | p.Thr1375Ile | p.T1375I | protein_coding | deleterious(0.04) | benign(0.081) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
DMXL1 | SNV | Missense_Mutation | c.6907N>T | p.Leu2303Phe | p.L2303F | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | ||
DMXL1 | SNV | Missense_Mutation | novel | c.2189N>A | p.Ser730Tyr | p.S730Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DMXL1 | SNV | Missense_Mutation | rs754689697 | c.5798G>T | p.Gly1933Val | p.G1933V | protein_coding | tolerated(0.08) | benign(0.036) | TCGA-AZ-4614-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DMXL1 | SNV | Missense_Mutation | novel | c.2370N>C | p.Glu790Asp | p.E790D | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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